Novel Serological Biomarker Models Composed of Bone Turnover Markers, Vitamin D, and Estradiol and Their Auxiliary Diagnostic Value in Girls with Idiopathic Central Precocious Puberty

Bone ◽  
2021 ◽  
pp. 116221
Author(s):  
Jing Zhang ◽  
Rui Gao ◽  
Yongmei Jiang ◽  
Yiduo Zhang ◽  
Chuanjiao Liu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Precocious Puberty ◽  
Bone Turnover Markers ◽  
Central Precocious Puberty ◽  
Diagnostic Value ◽  
Idiopathic Central Precocious Puberty ◽  
Turnover Markers

Predictors and relationships of serum 25 hydroxyvitamin D concentration with bone turnover markers, bone mineral density, and vitamin D receptor genotype in Emirati women

Bone ◽  
2006 ◽  
Vol 39 (5) ◽  
pp. 1136-1143 ◽  
Author(s):  
Hussein F. Saadi ◽  
Nicolaas Nagelkerke ◽  
Sheela Benedict ◽  
Hussein S. Qazaq ◽  
Erica Zilahi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Turnover Markers

scholarly journals Serum levels of bone formation and resorption markers in relation to vitamin D status in professional gymnastics and physically active men during upper and lower body high-intensity exercise

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Jan Mieszkowski ◽  
Andrzej Kochanowicz ◽  
Elżbieta Piskorska ◽  
Bartłomiej Niespodziński ◽  
Joanna Siódmiak ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Formation ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Type I Collagen ◽  
Serum Levels ◽  
Type I ◽  
Vitamin D Metabolites ◽  
Physically Active ◽  
Turnover Markers

Abstract Purpose/introduction To compare serum levels of bone turnover markers in athletes and non-athletes, and to evaluate the relationship between serum levels of vitamin D metabolites and exercise-induced changes in biomarker levels. Methods Sixteen elite male artistic gymnasts (EG; 21.4 ± 0.8 years-old) and 16 physically active men (the control group, PAM; 20.9 ± 1.2 years-old) performed lower and upper body 30-s Wingate anaerobic tests (LBWT and UBWT, respectively). For biomarker analysis, blood samples were collected before, and 5 and 30 min after exercise. Samples for vitamin D levels were collected before exercise. N-terminal propeptide of type I collagen (PINP) was analysed as a marker of bone formation. C-terminal telopeptide of type I collagen (CTX) was analysed as a marker of bone resorption. Results UBWT fitness readings were better in the EG group than in the PAM group, with no difference in LBWT readings between the groups. UBWT mean power was 8.8% higher in subjects with 25(OH)D3 levels over 22.50 ng/ml and in those with 24,25(OH)2D3 levels over 1.27 ng/ml. Serum CTX levels increased after both tests in the PAM group, with no change in the EG group. PINP levels did not change in either group; however, in PAM subjects with 25(OH)D3 levels above the median, they were higher than those in EG subjects. Conclusion Vitamin D metabolites affect the anaerobic performance and bone turnover markers at rest and after exercise. Further, adaptation to physical activity modulates the effect of anaerobic exercise on bone metabolism markers.

Effect of isolated vitamin D supplementation on the bone turnover markers in postmenopausal women: Randomized, double-blind, placebo controlled trial

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 154 ◽  
Author(s):  
Jorge Nahas-Neto ◽  
Luciana Cangussu ◽  
Claudio Orsatti ◽  
Flavia Bueloni-Dias ◽  
Priscila Poloni ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Bone Turnover Markers ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Turnover Markers

scholarly journals Per oral substitution with 300000 IU vitamin D (Cholecalciferol) reduces bone turnover markers in HIV-infected patients

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Rein Jan Piso ◽  
Madeleine Rothen ◽  
Jean Pierre Rothen ◽  
Matthias Stahl ◽  
Christoph Fux
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Turnover Markers ◽  
Per Oral

Vitamin D insufficiency in adolescent males in Southern Tasmania: prevalence, determinants, and relationship to bone turnover markers

2004 ◽  
Vol 16 (6) ◽  
pp. 636-641 ◽  
Author(s):  
Graeme Jones ◽  
Terry Dwyer ◽  
Kristen L. Hynes ◽  
Venkat Parameswaran ◽  
Timothy M. Greenaway
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Vitamin D Insufficiency ◽  
Adolescent Males ◽  
Turnover Markers

scholarly journals Effect of vitamin D fortified foods on bone markers and muscle strength in women of Pakistani and Danish origin living in Denmark: a randomised controlled trial

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Ida M. Grønborg ◽  
Inge Tetens ◽  
Elisabeth Wreford Andersen ◽  
Michael Kristensen ◽  
Rikke E. K. Larsen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Bone Markers ◽  
Knee Extension ◽  
Fortified Foods ◽  
Knee Extension Strength ◽  
Turnover Markers

Abstract Background Deficient and insufficient vitamin D status (defined as serum 25(OH)D < 30 nmol/L and > 50 nmol/L) is prevalent worldwide and associated with decreased muscle strength and poor bone health. We aimed to investigate the effect of vitamin D fortification on bone markers and muscle strength among younger adult women at risk of vitamin D deficiency. Methods A 12-week randomised double-blinded placebo-controlled winter intervention trial, providing 30 μg vitamin D3/day through fortified yoghurt, cheese, eggs and crisp-bread or similar placebo products. Participants were 143 women of Danish and Pakistani origin 18–50 years of age, living in Denmark, randomised into four groups stratified by ethnicity. Serum 25-hydroxyvitamin D (25(OH)D) by LC-MS/MS and the secondary endpoints: four specific bone markers (osteocalcin (OC), Bone specific Alkaline Phosphatase (BALP), Procollagen type 1 amino-terminal propeptide (P1NP), C-terminal crosslinked telopeptide of type 1 collagen (CTX)) and three muscle strength measures (handgrip, knee extension strength, chair-standing), were assessed using one-way ANOVA, Tukey HSD and subsequent linear ANCOVA models, adjusted for relevant covariates. Results Significantly increased serum 25(OH)D concentration from 53.3 (17) to 77.8 (14) nmol/L and from 44.5 (21) to 54.7 (18) nmol/L among Danish and Pakistani women in the fortified groups, respectively (P <  0.05). The bone turnover markers OC, BALP, P1NP and CTX did not change significantly. Muscle strength by handgrip, knee extension and chair-standing test did not change significantly following the intervention. Conclusions Consumption of vitamin D fortified foods for 12 weeks did not result in significant changes of the bone turnover markers OC, BALP, P1NP and CTX. Muscle strength measured as hand grip strength, knee extension strength and chair-standing did not change significantly following the intervention.

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