Ferulic Acid Modulates Dysfunctional Metabolic Pathways and Purinergic Activities, While Stalling Redox Imbalance and Cholinergic Activities in Oxidative Brain Injury

Abstract Lymphocytes are one of the most important cells involved in the pathophysiology of psoriasis; therefore, the aim of this study was to assess the redox imbalance and protein modifications in the lymphocytes of patients with psoriasis vulgaris (PsV) or psoriatic arthritis (PsA). The results show a stronger shift in redox status to pro-oxidative conditions (observed as an increased reactive oxygen species level, a decrease in catalase activity and lower levels of glutathione peroxidase and vitamin E compared with healthy controls) in the lymphocytes of PsA than PsV patients. It is also favoured by the enhanced level of activators of the Nrf2 transcription factor in lymphocytes of PsV compared with decreased of these proteins level in PsA. Moreover, the differential modifications of proteins by lipid peroxidation products 4-oxononenal (mainly binding proteins) and malondialdehyde (mainly catalytic proteins with redox activity), promoted a pro-apoptotic pathway in lymphocytes of PsV, which was manifested by enhanced expression of pro-apoptotic caspases, particularly caspase 3. Taken together, differences in Nrf2 pathway activation may be responsible for the differential level of redox imbalance in lymphocytes of patients with PsV and PsA. This finding may enable identification of a targeted therapy to modify the metabolic pathways disturbed in psoriasis.

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Casein micelles from bovine Milk exerts Neuroprotection by stalling metabolic complications linked to oxidative brain injury

Metabolic Brain Disease ◽

10.1007/s11011-020-00621-3 ◽

2020 ◽

Vol 35 (8) ◽

pp. 1417-1428

Author(s):

Ochuko L. Erukainure ◽

Veronica F. Salau ◽

Opeyemi O. Alabi ◽

Osaretin A. T. Ebuehi ◽

Neil A. Koorbanally ◽

...

Keyword(s):

Brain Injury ◽

Bovine Milk ◽

Casein Micelles ◽

Metabolic Complications ◽

Oxidative Brain Injury

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Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage

Brain Research ◽

10.1016/s0006-8993(02)03268-7 ◽

2002 ◽

Vol 953 (1-2) ◽

pp. 45-52 ◽

Cited By ~ 141

Author(s):

Jimin Wu ◽

Ya Hua ◽

Richard F Keep ◽

Timothy Schallert ◽

Julian T Hoff ◽

...

Keyword(s):

Brain Injury ◽

Intracerebral Hemorrhage ◽

Oxidative Brain Injury

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Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications

Biochemistry Insights ◽

10.4137/bci.s36141 ◽

2016 ◽

Vol 9 ◽

pp. BCI.S36141 ◽

Cited By ~ 25

Author(s):

Hong Zheng ◽

Jinzi Wu ◽

Zhen Jin ◽

Liang-Jun Yan

Keyword(s):

Oxidative Stress ◽

Posttranslational Modifications ◽

Metabolic Pathways ◽

Polyol Pathway ◽

Protein Modifications ◽

Redox Imbalance ◽

Adp Ribosylation ◽

Carbon Stress

Diabetes and its complications are hyperglycemic toxicity diseases. Many metabolic pathways in this array of diseases become aberrant, which is accompanied with a variety of posttranslational protein modifications that in turn reflect diabetic glucotoxicity. In this review, we summarize some of the most widely studied protein modifications in diabetes and its complications. These modifications include glycation, carbonylation, nitration, cysteine S-nitrosylation, acetylation, sumoylation, ADP-ribosylation, O-GlcNAcylation, and succination. All these posttranslational modifications can be significantly attributed to oxidative stress and/or carbon stress induced by diabetic redox imbalance that is driven by activation of pathways, such as the polyol pathway and the ADP-ribosylation pathway. Exploring the nature of these modifications should facilitate our understanding of the pathological mechanisms of diabetes and its associated complications.

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