Truncal Ataxia and Prolonged Coma in an Exploratory Pediatric Perampanel Ingestion

2021 ◽  
Author(s):  
Diana Dean ◽  
Karla D. Passalacqua ◽  
Bram Dolcourt
Keyword(s):  
Truncal Ataxia ◽  
Prolonged Coma

Prognosis of patients in prolonged coma after severe carbon monoxide poisoning

2021 ◽  
pp. 096032712199799
Author(s):  
Y Gao ◽  
H Gu ◽  
J Yang ◽  
L Yang ◽  
Z Li ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Poor Prognosis ◽  
Vegetative State ◽  
Carbon Monoxide Poisoning ◽  
Demographic Data ◽  
Laboratory Data ◽  
Persistent Vegetative State ◽  
Chronic Phase ◽  
Imaging Features ◽  
Prolonged Coma

Background: Late recovery in patients following prolonged coma from carbon monoxide poisoning have been reported, but the probability is unclear. The purpose of this research was to assess the prognosis of patients in prolonged coma after severe carbon monoxide poisoning and related clinical and imaging features. Methods: There were 13 patients who had been in a state of coma for >7 days after acute carbon monoxide poisoning in the retrospective observational study, and demographic data, clinical data, laboratory data, complications, and image data were collected. Outcome was assessed by means of the Glasgow outcome scale after 1 year. The relationship between complications and imaging manifestations and prognosis was also analyzed. Results: One year after severe carbon monoxide poisoning, two patients (15.4%) had died (GOS 1), nine (69.2%) were in a persistent vegetative state (GOS 2), one (7.7%) was moderately disabled (GOS 4), and one (7.7%) achieved a good recovery (GOS 5) with minimal disability. Conclusions: Most patients with prolonged coma after severe carbon monoxide poisoning had a poor prognosis, although the younger patients had a better prognosis. Respiratory failure, hypotension and renal failure during the course of the disease were associated with a poor prognosis. The prognosis of patients with injuries in two sites in early CT was poor. Multiple lesions (≥3) and extensive white matter damage (Fazekas grade (PVH or DWMH) = 3) on MRI of chronic phase were also associated with a poor prognosis.

Truncal ataxia in chronic anticonvulsant treatment

1982 ◽  
Vol 55 (3) ◽  
pp. 305-311 ◽  
Author(s):  
David Muñoz-Garcia ◽  
Teodoro Del Ser ◽  
Felix Bermejo ◽  
Alberto Portera
Keyword(s):  
Truncal Ataxia ◽  
Anticonvulsant Treatment

scholarly journals Cerebellar atrophy is frequently associated with non-paraneoplastic sensory neuronopathy

2011 ◽  
Vol 69 (4) ◽  
pp. 602-606 ◽  
Author(s):  
Alfredo Damasceno ◽  
Marcondes C. França Jr ◽  
Fernando Cendes ◽  
Anamarli Nucci
Keyword(s):  
Cerebellar Atrophy ◽  
Anterior Lobe ◽  
Dorsal Root Ganglion Neurons ◽  
Volume Index ◽  
Cerebellar Volume ◽  
Truncal Ataxia ◽  
Immune Mediated ◽  
Mri Volumetry ◽  
And Gender ◽  
Ganglion Neurons

Sensory neuronopathies (SN) are peripheral nervous system disorders associated with degeneration of dorsal root ganglion neurons. Despite the evidence of a defective proprioceptive sensory input in SN,the prominent gait and truncal ataxia raises the question of a concomitant involvement of the cerebellum. OBJECTIVE: To evaluate cerebellar atrophy in SN. METHOD: We analyzed MRI-based volumetry of anterior lobe (paleocerebellum) and total cerebellum in patients with non-paraneoplastic chronic SN and compared to age- and gender-matched controls. RESULTS: Cerebellum and anterior lobe MRI volumetry were performed in 20 patients and nine controls. Mean anterior lobe and cerebellar volume were not statistically different. Three patients (15%), however, had an abnormal anterior lobe and cerebellar volume index (values outside 2.5 standard deviations). One of them also had a specific atrophy of the anterior lobe. All these patients had infectious or dysimmune associated SN. CONCLUSION: Cerebellar atrophy is infrequently associated with SN, but can be found in some patients with SN related to infectious or immune mediated conditions. It can be more prominent in the anterior lobe and may contribute to the ataxia seen in these patients.

scholarly journals Case Report: Novel SLC9A6 Splicing Variant in a Chinese Boy With Christianson Syndrome With Electrical Status Epilepticus During Sleep

2022 ◽  
Vol 12 ◽  
Author(s):  
Xiaorui Liu ◽  
Lingling Xie ◽  
Zhixu Fang ◽  
Li Jiang
Keyword(s):  
Status Epilepticus ◽  
Rna Splicing ◽  
Pcr Analysis ◽  
Global Developmental Delay ◽  
Significant Feature ◽  
Rt Pcr ◽  
Computer Prediction ◽  
Splicing Variant ◽  
Truncal Ataxia ◽  
Dna And Rna

We investigated the existence and potential pathogenicity of a SLC9A6 splicing variant in a Chinese boy with Christianson Syndrome (CS), which was reported for the first time in China. Trio whole-exome sequencing (WES) was performed in the proband and his parents. Multiple computer prediction tools were used to evaluate the pathogenicity of the variant, and reverse transcription-polymerase chain reaction (RT-PCR) analysis and cDNA sequencing were performed to verify the RNA splicing results. The patient presented with characteristic features of CS: global developmental delay, seizures, absent speech, truncal ataxia, microcephaly, ophthalmoplegia, smiling face and hyperkinesis with electrical status epilepticus during sleep (ESES) detected in an electroencephalogram (EEG). A SLC9A6 splicing variant was identified by WES and complete skipping of exon 10 was confirmed by RT-PCR. This resulted in altered gene function and was predicted to be pathogenic. ESES observed early in the disease course is considered to be a significant feature of CS with the SLC9A6 variant. Combined genetic analysis at both the DNA and RNA levels is necessary to confirm the pathogenicity of this variant and its role in the clinical diagnosis of CS.

scholarly journals Vermal cerebellar hemorrhage as the initial manifestation of undiagnosed hypertension

2016 ◽  
Vol 5 (1) ◽  
pp. 357 ◽  
Author(s):  
Alagoma Iyagba ◽  
Arthur Onwuchekwa
Keyword(s):  
Sudden Onset ◽  
Lower Limbs ◽  
Neck Stiffness ◽  
Cerebellar Haemorrhage ◽  
Initial Manifestation ◽  
Truncal Ataxia ◽  
Accident And Emergency ◽  
Undiagnosed Hypertension ◽  
History Of ◽  
Clonic Seizures

Vermal cerebellar haemorrhage is bleeding affecting the midline region of the cerebellum. It is uncommon, accounting for 5-13% of all intracerebral haemorrhages. It is a grave condition with a high mortality. The diagnosis must be made early, if not, most patients would die within 48 hours. A 70-year-old lady presented to the accident and emergency department with a six hours history of sudden onset generalized tonic-clonic seizures following activity and loss of consciousness. She was unconscious with a Glasgow coma score of 3/15 with neck stiffness, generalized hypotonia and globally diminished reflexes. Her blood pressure was 240/120 mmHg with a mean arterial pressure of 160 mmHg. The brain computerized tomographic scan showed a hyperdense area in the cerebellar vermis with extension to both hemispheres and fourth ventricle. Consciousness was regained after three weeks of conservative management following which she became extremely restless and noticed to have developed titubations with nystagmus of both eyes. She also developed intention tremors, scanning dysarthria, generalized hypotonia, dysmetria, dysdiadochokinesia and intentional bilateral tremors. Her recovery was slow and gradual. Once she was able to stand with support, she was noticed to have florid truncal ataxia, lower limbs ataxia, and titubations.

TRUNCAL ATAXIA AS A COMPLICATION OF COLISTIN THERAPY

1967 ◽  
Vol 46 (1) ◽  
pp. 46???48 ◽  
Author(s):  
STEPHEN J. PREVOZNIK
Keyword(s):  
Truncal Ataxia

scholarly journals The Differential Diagnosis of Acute Onset Truncal Ataxia: The Importance of Dysgeusia in Miller Fisher Syndrome

2018 ◽  
Vol 57 (14) ◽  
pp. 2057-2060 ◽  
Author(s):  
Tatsuya Ueno ◽  
Ryoya Kimura ◽  
Tomoya Kon ◽  
Rie Haga ◽  
Haruo Nishijima ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Acute Onset ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
Truncal Ataxia

Prolonged Coma

1968 ◽  
Vol 13 (2) ◽  
pp. 197-197
Author(s):  
William H. Sweet
Keyword(s):  
Prolonged Coma

Case of acute onset ataxia caused by Klebsiella pneumoniae sepsis with the appearance of anti-GD1b antibody

2021 ◽  
Vol 14 (8) ◽  
pp. e242396
Author(s):  
Shigeo Yamada ◽  
Takashi Umeya
Keyword(s):  
Klebsiella Pneumoniae ◽  
Polymyxin B ◽  
Endotoxin Shock ◽  
Acute Onset ◽  
Serum Samples ◽  
Igg Antibody ◽  
Fisher Syndrome ◽  
Truncal Ataxia ◽  
Genetic Features ◽  
Suppurative Cholangitis

Various disorders can cause acute onset ataxia including those that have toxic/metabolic, traumatic, neoplastic, vascular, demyelinating/dysmyelinating, infectious, postinfectious and genetic features. We present a case of postseptic acute ataxia. A 72-year-old woman was diagnosed with septic shock secondary to acute obstructive suppurative cholangitis. A blood sample for bacterial culture was positive for Klebsiella pneumoniae. Thus, we initiated antibiotics and intravenous immunoglobulin therapies to control the infection. We later added extracorporeal endotoxin removal with a polymyxin B immobilised fibre cartridge for endotoxin shock. The patient’s condition improved soon after endotoxin removal. Mildly slurred and explosive speech with limb and truncal ataxia, which improved gradually, developed shortly afterwards. Serum samples obtained on day 15 after admission were positive for anti-GD1b IgG antibody. The clinical course of monophasic illness with good recovery, neurological findings and the appearance of anti-GD1b antibody suggest that this case is a variant of Miller-Fisher syndrome.

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