Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes

Pprom (preterm premature rupture of membranes )is one of the most common complication of pregnancy contributing to major fetal morbidity and mortality. So it is important to study causes like micronutrient deficiency which can lead to pprom so that it can be prevented and hence fetal complications can be reduced.Place of study: Department of Obstetrics & Gynecology, Jawahar Lal Nehru Medical College and Hospital, Bhagalpur, Bihar.Duration of study: period of 1 year. Prospective randomised study.

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The Effect of Stress and Warfarin on the Adrenal Gland in Relation to Spontaneous Hemorrhage, as Judged by Measurement of Adrenal Ascorbic Acid and Serum Corticosterone

Thrombosis and Haemostasis ◽

10.1055/s-0038-1653675 ◽

1971 ◽

Vol 26 (02) ◽

pp. 275-288 ◽

Cited By ~ 3

Author(s):

S Chattopadhyay ◽

D. D Johnson ◽

G. J Millar ◽

L. B Jaques

Keyword(s):

Ascorbic Acid ◽

Acid Concentration ◽

Ascorbic Acid Concentration ◽

Corticosterone Concentration ◽

Serum Corticosterone ◽

Spontaneous Hemorrhage ◽

Combined Action ◽

Series Of Experiments ◽

Pituitary Adrenal Axis

SummaryRats were subjected to the following procedures: No treatment, Stressor (10% NaCl i.p.), Warfarin for 7 days, Stressor followed by Warfarin; and groups were sacrificed at intervals for assessment of spontaneous hemorrhage and of adrenal ascorbic acid concentration. There was no hemorrhage in the no treatment and stressor groups; some hemorrhage in the warfarin group; profound hemorrhage with Warfarin + Stressor. The adrenal ascorbic acid concentration was found to be lower, 8 h and again 5 days after stress, and remained lower in the warfarin + stress animals. Warfarin had no effect on adrenal ascorbic acid level.In another series of experiments in which the stress consisted of an electric current to the cage floor for 6 sec over 15 min, rats were sacrificed daily for determination of serum corticosterone concentration and occurrence of spontaneous hemorrhage. There was a statistically significant increase of serum corticosterone concentration with stress, warfarin and combined warfarin and stress treatments (P< 0.001 for all three variables). There was a significant correlation (r = 0.96 and 0.89, P< 0.01) for serum corticosterone concentration with hemorrhage score and incidence of hemorrhage in stressed rats receiving warfarin, but not in those receiving only warfarin. The results indicate an activation, rather than an exhaustion, of the pituitary-adrenal axis during the combined action of anticoagulant and stress, which results in the development of spontaneous hemorrhage.

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Preterm Premature Rupture of Membranes in Twins: Comparison of Rupture in the Presenting Versus Non-presenting Sac

Journal of Obstetrics and Gynaecology Canada ◽

10.1016/j.jogc.2019.06.016 ◽

2020 ◽

Vol 42 (2) ◽

pp. 163-168 ◽

Cited By ~ 1

Author(s):

Elad Mei-Dan ◽

Zoe Hutchison ◽

Mark Osmond ◽

Susan Pakenham ◽

Eugene Ng ◽

...

Keyword(s):

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture

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Impact of high temperature stress on ascorbic acid concentration in tomato

Acta Horticulturae ◽

10.17660/actahortic.2018.1194.140 ◽

2018 ◽

pp. 985-990

Author(s):

V. Hernández ◽

P. Hellín ◽

J. Fenoll ◽

M.V. Molina ◽

I. Garrido ◽

...

Keyword(s):

Ascorbic Acid ◽

High Temperature ◽

Temperature Stress ◽

Acid Concentration ◽

High Temperature Stress ◽

Ascorbic Acid Concentration

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Prevention and Therapy of Preterm Birth. Guideline of the DGGG, OEGGG and SGGG (S2k Level, AWMF Registry Number 015/025, February 2019) – Part 2 with Recommendations on the Tertiary Prevention of Preterm Birth and the Management of Preterm Premature Rupture of Membranes

Geburtshilfe und Frauenheilkunde ◽

10.1055/a-0903-2735 ◽

2019 ◽

Vol 79 (08) ◽

pp. 813-833 ◽

Cited By ~ 2

Author(s):

Richard Berger ◽

Harald Abele ◽

Franz Bahlmann ◽

Ivonne Bedei ◽

Klaus Doubek ◽

...

Keyword(s):

Preterm Birth ◽

German Society ◽

Consensus Conference ◽

Tertiary Prevention ◽

Short Version ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Gynecology And Obstetrics ◽

Self Help Groups

Abstract Aims This is an official guideline of the German Society for Gynecology and Obstetrics (DGGG), the Austrian Society for Gynecology and Obstetrics (ÖGGG) and the Swiss Society for Gynecology and Obstetrics (SGGG). The aim of this guideline is to improve the prediction, prevention and management of preterm birth based on evidence obtained from recently published scientific literature, the experience of the members of the guideline commission and the views of self-help groups. Methods The members of the participating medical societies and organizations developed Recommendations and Statements based on the international literature. The Recommendations and Statements were adopted following a formal consensus process (structured consensus conference with neutral moderation, voting done in writing using the Delphi method to achieve consensus). Recommendations Part 2 of this short version of the guideline presents Statements and Recommendations on the tertiary prevention of preterm birth and the management of preterm premature rupture of membranes.

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THE EFFECT OF “AMPARON” UPON THE ASCORBIC ACID CONCENTRATION IN THE ADRENAL GLANDS OF HYPOPHYSECTOMIZED RATS

The Medical Journal of Australia ◽

10.5694/j.1326-5377.1954.tb85475.x ◽

1954 ◽

Vol 1 (12) ◽

pp. 430-432

Author(s):

L. A. G. Hrssink

Keyword(s):

Ascorbic Acid ◽

Acid Concentration ◽

Adrenal Glands ◽

Ascorbic Acid Concentration ◽

Hypophysectomized Rats

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Neonatal lymphocyte subpopulations analysis and maternal preterm premature rupture of membranes: a pilot study

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2021-0375 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Margherita Amadi ◽

Silvia Visentin ◽

Francesca Tosato ◽

Paola Fogar ◽

Giulia Giacomini ◽

...

Keyword(s):

T Cells ◽

Immune System ◽

T Cell ◽

T Helper Cells ◽

Lymphocyte Subpopulations ◽

T Helper ◽

Premature Rupture Of Membranes ◽

Premature Rupture ◽

Preterm Premature Rupture ◽

Helper Cells

Abstract Objectives Preterm premature rupture of membranes (pPROM) causes preterm delivery, and increases maternal T-cell response against the fetus. Fetal inflammatory response prompts maturation of the newborn’s immunocompetent cells, and could be associated with unfavorable neonatal outcome. The aims were to examine the effects of pPROM (Mercer BM. Preterm premature rupture of the membranes: current approaches to evaluation and management. Obstet Gynecol Clin N Am 2005;32:411) on the newborn’s and mother’s immune system and (Test G, Levy A, Wiznitzer A, Mazor M, Holcberg G, Zlotnik A, et al. Factors affecting the latency period in patients with preterm premature rupture of membranes (pPROM). Arch Gynecol Obstet 2011;283:707–10) to assess the predictive value of immune system changes in neonatal morbidity. Methods Mother-newborn pairs (18 mothers and 23 newborns) who experienced pPROM and controls (11 mothers and 14 newborns), were enrolled. Maternal and neonatal whole blood samples underwent flow cytometry to measure lymphocyte subpopulations. Results pPROM-newborns had fewer naïve CD4 T-cells, and more memory CD4 T-cells than control newborns. The effect was the same for increasing pPROM latency times before delivery. Gestational age and birth weight influenced maturation of the newborns’ lymphocyte subpopulations and white blood cells, notably cytotoxic T-cells, regulatory T-cells, T-helper cells (absolute count), and CD4/CD8 ratio. Among morbidities, fewer naïve CD8 T-cells were found in bronchopulmonary dysplasia (BPD) (p=0.0009), and more T-helper cells in early onset sepsis (p=0.04). Conclusions pPROM prompts maturation of the newborn’s T-cell immune system secondary to antigenic stimulation, which correlates with pPROM latency. Maternal immunity to inflammatory conditions is associated with a decrease in non-major histocompatibility complex (MHC)-restricted cytotoxic cells.

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Interference of ascorbic acid with chemical analytes

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1258/000456305774538274 ◽

2005 ◽

Vol 42 (6) ◽

pp. 475-477 ◽

Cited By ~ 15

Author(s):

Qing H Meng ◽

William C Irwin ◽

Jennifer Fesser ◽

K Lorne Massey

Keyword(s):

Ascorbic Acid ◽

Creatine Kinase ◽

Uric Acid ◽

Total Cholesterol ◽

Acid Concentration ◽

Total Bilirubin ◽

Binding Capacity ◽

Ascorbic Acid Concentration ◽

Sodium Potassium ◽

Creatine Kinase Mb

Background: Ascorbic acid can interfere with methodologies involving redox reactions, while comprehensive studies on main chemistry analysers have not been reported. We therefore attempted to determine the interference of ascorbic acid with analytes on the Beckman Synchron LX20®. Methods: Various concentrations of ascorbic acid were added to serum, and the serum analytes were measured on the LX20. Results: With a serum ascorbic acid concentration of 12.0 mmol/L, the values for sodium, potassium, calcium and creatinine increased by 43%, 58%, 103% and 26%, respectively ( P<0.01). With a serum ascorbic acid concentration of 12.0 mmol/L, the values for chloride, total bilirubin and uric acid decreased by 33%, 62% and 83%, respectively ( P<0.01), and were undetectable for total cholesterol, triglyceride, ammonia and lactate. There was no definite influence of ascorbic acid on analytical values for total CO2, urea, glucose, phosphate, total protein, albumin, amylase, creatine kinase, creatine kinase-MB, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total iron, unbound iron-binding capacity or magnesium. Conclusions: Ascorbic acid causes a false increase in sodium, potassium, calcium and creatinine results and a false decrease in chloride, total bilirubin, uric acid, total cholesterol, triglyceride, ammonia and lactate results.

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