scholarly journals 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection

2016 ◽  
Vol 7 (11) ◽  
pp. 839-843 ◽  
Author(s):  
Song Wang ◽  
Xiaoqin Luo ◽  
Ruoxiang Yan ◽  
Quanxin Wang ◽  
Qiuyue Qi ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
In Vivo Efficacy ◽  
Influenza A Virus Infection

scholarly journals Influenza A Virus Infection Induces Apical Redistribution of Na+, K+-ATPase in Lung Epithelial Cells In Vitro and In Vivo

2019 ◽  
Vol 61 (3) ◽  
pp. 395-398
Author(s):  
Christin Peteranderl ◽  
Irina Kuznetsova ◽  
Jessica Schulze ◽  
Martin Hardt ◽  
Emilia Lecuona ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Influenza A Virus Infection

scholarly journals Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Guihong Yang ◽  
Huipeng Huang ◽  
Mengyao Tang ◽  
Zifeng Cai ◽  
Cuiqin Huang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
A549 Cells ◽  
Virus Challenge ◽  
Neuromedin B ◽  
Influenza A Virus Infection

Abstract The peptide neuromedin B (NMB) and its receptor (NMBR) represent a system (NMB/NMBR) of neuromodulation. Here, it was demonstrated that the expression of NMBR in cells or murine lung tissues was clearly upregulated in response to H1N1/PR8 influenza A virus infection. Furthermore, the in vitro and in vivo activities of NMB/NMBR during PR8 infection were investigated. It was observed that A549 cells lacking endogenous NMBR were more susceptible to virus infection than control cells, as evidenced by the increased virus production in the cells. Interestingly, a significant decrease in IFN-α and increased IL-6 expression were observed in these cells. The role of this system in innate immunity against PR8 infection was probed by treating mice with NMB. The NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. Additionally, the results showed that exogenous NMB not only enhanced IFN-α expression but also appeared to inhibit the expression of NP and IL-6 in PR8-infected cells and animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB. Together, these data suggest that NMB/NMBR may be an important component of the host defence against influenza A virus infection. Thus, these proteins may serve as promising candidates for the development of novel antiviral drugs.

scholarly journals L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo

2012 ◽  
Vol 4 (3) ◽  
pp. 312-324 ◽  
Author(s):  
Qin Pan ◽  
Haidan Chen ◽  
Feng Wang ◽  
Victor Tunje Jeza ◽  
Wei Hou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

CD14 plays a limited role during influenza A virus infection in vivo

2007 ◽  
Vol 113 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Mark C. Dessing ◽  
Koenraad F. van der Sluijs ◽  
Sandrine Florquin ◽  
Tom van der Poll
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Limited Role ◽  
Influenza A Virus Infection

scholarly journals Exploring virus release as a bottleneck for the spread of influenza A virus infection in vitro and the implications for antiviral therapy with neuraminidase inhibitors

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183621 ◽  
Author(s):  
Laura E. Liao ◽  
Szymon Kowal ◽  
Daniel A. Cardenas ◽  
Catherine A. A. Beauchemin
Keyword(s):  
Virus Infection ◽  
Antiviral Therapy ◽  
Influenza A Virus ◽  
Influenza A ◽  
Neuraminidase Inhibitors ◽  
Virus Release ◽  
Influenza A Virus Infection

Inhibition of Influenza A Virus Infection in Vitro by Saliphenylhalamide-Loaded Porous Silicon Nanoparticles

ACS Nano ◽  
2013 ◽  
Vol 7 (8) ◽  
pp. 6884-6893 ◽  
Author(s):  
Luis M. Bimbo ◽  
Oxana V. Denisova ◽  
Ermei Mäkilä ◽  
Martti Kaasalainen ◽  
Jef K. De Brabander ◽  
...  
Keyword(s):  
Porous Silicon ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Silicon Nanoparticles ◽  
Porous Silicon Nanoparticles ◽  
Influenza A Virus Infection

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

2012 ◽  
Vol 30 (12) ◽  
pp. 1210-1216 ◽  
Author(s):  
Benjamin Petsch ◽  
Margit Schnee ◽  
Annette B Vogel ◽  
Elke Lange ◽  
Bernd Hoffmann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Protective Efficacy ◽  
Influenza A Virus Infection ◽  
Specific Mrna

scholarly journals In Vivo Bioluminescent Imaging of Influenza A Virus Infection and Characterization of Novel Cross-Protective Monoclonal Antibodies

2013 ◽  
Vol 87 (15) ◽  
pp. 8272-8281 ◽  
Author(s):  
N. S. Heaton ◽  
V. H. Leyva-Grado ◽  
G. S. Tan ◽  
D. Eggink ◽  
R. Hai ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Bioluminescent Imaging ◽  
Influenza A Virus Infection
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