scholarly journals In Vivo Bioluminescent Imaging of Influenza A Virus Infection and Characterization of Novel Cross-Protective Monoclonal Antibodies

2013 ◽  
Vol 87 (15) ◽  
pp. 8272-8281 ◽  
Author(s):  
N. S. Heaton ◽  
V. H. Leyva-Grado ◽  
G. S. Tan ◽  
D. Eggink ◽  
R. Hai ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Bioluminescent Imaging ◽  
Influenza A Virus Infection

CD14 plays a limited role during influenza A virus infection in vivo

2007 ◽  
Vol 113 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Mark C. Dessing ◽  
Koenraad F. van der Sluijs ◽  
Sandrine Florquin ◽  
Tom van der Poll
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Limited Role ◽  
Influenza A Virus Infection

scholarly journals Influenza A Virus Infection Induces Apical Redistribution of Na+, K+-ATPase in Lung Epithelial Cells In Vitro and In Vivo

2019 ◽  
Vol 61 (3) ◽  
pp. 395-398
Author(s):  
Christin Peteranderl ◽  
Irina Kuznetsova ◽  
Jessica Schulze ◽  
Martin Hardt ◽  
Emilia Lecuona ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Lung Epithelial Cells ◽  
Lung Epithelial ◽  
Influenza A Virus Infection

scholarly journals Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo

2019 ◽  
Vol 50 (1) ◽  
Author(s):  
Guihong Yang ◽  
Huipeng Huang ◽  
Mengyao Tang ◽  
Zifeng Cai ◽  
Cuiqin Huang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
A549 Cells ◽  
Virus Challenge ◽  
Neuromedin B ◽  
Influenza A Virus Infection

Abstract The peptide neuromedin B (NMB) and its receptor (NMBR) represent a system (NMB/NMBR) of neuromodulation. Here, it was demonstrated that the expression of NMBR in cells or murine lung tissues was clearly upregulated in response to H1N1/PR8 influenza A virus infection. Furthermore, the in vitro and in vivo activities of NMB/NMBR during PR8 infection were investigated. It was observed that A549 cells lacking endogenous NMBR were more susceptible to virus infection than control cells, as evidenced by the increased virus production in the cells. Interestingly, a significant decrease in IFN-α and increased IL-6 expression were observed in these cells. The role of this system in innate immunity against PR8 infection was probed by treating mice with NMB. The NMB-treated mice were less susceptible to virus challenge, as evidenced by increased survival, increased body weight, and decreased viral NP expression compared with the control animals. Additionally, the results showed that exogenous NMB not only enhanced IFN-α expression but also appeared to inhibit the expression of NP and IL-6 in PR8-infected cells and animals. As expected, opposing effects were observed in the NMBR antagonist-treated cells and mice, which further confirmed the effects of NMB. Together, these data suggest that NMB/NMBR may be an important component of the host defence against influenza A virus infection. Thus, these proteins may serve as promising candidates for the development of novel antiviral drugs.

scholarly journals Characterization of Influenza A Virus Infection in Mouse Pulmonary Stem/Progenitor Cells

2020 ◽  
Vol 10 ◽  
Author(s):  
Tai-Ling Chao ◽  
Sing-Yi Gu ◽  
Pi-Han Lin ◽  
Yu-Tien Chou ◽  
Thai-Yen Ling ◽  
...  
Keyword(s):  
Virus Infection ◽  
Progenitor Cells ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals Characterization of a new H-2Dk-restricted epitope prominent in primary influenza A virus infection

2001 ◽  
Vol 82 (7) ◽  
pp. 1749-1755 ◽  
Author(s):  
Sophie Tourdot ◽  
Shan Herath ◽  
Keith G. Gould
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Dominance Hierarchy ◽  
Influenza Virus Infection ◽  
Amino Acid Residues ◽  
Influenza A Virus Infection ◽  
Restricted Epitope

Influenza A virus infection of mice has been used extensively as a model to investigate the mechanisms of antigen presentation to cytotoxic T lymphocytes (CTL) and the phenomenon of immunodominance in antiviral CTL responses. The different virus-encoded epitopes that are recognized in H-2b and H-2d mice have been characterized and their relative immunodominance has been well-studied. In H-2k mice, four different Kk-restricted influenza virus epitopes have been described, but the dominance hierarchy of these epitopes is unknown and there is also an uncharacterized Dk-restricted response against the virus. In this study, a Dk-restricted epitope derived from the influenza virus A/PR/8/34 polymerase protein PB1, corresponding to amino acid residues 349–357 (ARLGKGYMF), was identified. This peptide is the major epitope within the PB1 polymerase and is at least as dominant as any of the four Kk-restricted epitopes that are recognized in CBA mice following primary influenza virus infection. The PB1 epitope is only the fourth Dk-presented peptide to be reported and the sequence of this epitope confirms a Dk-restricted peptide motif, consisting of arginine at position two, arginine or lysine at position five and a hydrophobic residue at the carboxy terminus.

scholarly journals Cross-protective potential of anti-nucleoprotein human monoclonal antibodies against lethal influenza A virus infection

2016 ◽  
Vol 97 (9) ◽  
pp. 2104-2116 ◽  
Author(s):  
Yoshikazu Fujimoto ◽  
Yukiko Tomioka ◽  
Hiroki Takakuwa ◽  
Gen-Ichiro Uechi ◽  
Toshiyo Yabuta ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Human Monoclonal Antibodies ◽  
Protective Potential ◽  
Influenza A Virus Infection

scholarly journals L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo

2012 ◽  
Vol 4 (3) ◽  
pp. 312-324 ◽  
Author(s):  
Qin Pan ◽  
Haidan Chen ◽  
Feng Wang ◽  
Victor Tunje Jeza ◽  
Wei Hou ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection

2016 ◽  
Vol 7 (11) ◽  
pp. 839-843 ◽  
Author(s):  
Song Wang ◽  
Xiaoqin Luo ◽  
Ruoxiang Yan ◽  
Quanxin Wang ◽  
Qiuyue Qi ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
In Vivo Efficacy ◽  
Influenza A Virus Infection

Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection

2016 ◽  
Vol 16 (1) ◽  
pp. 217-227 ◽  
Author(s):  
Wojciech Cypryk ◽  
Martina Lorey ◽  
Anne Puustinen ◽  
Tuula A. Nyman ◽  
Sampsa Matikainen
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Extracellular Vesicles ◽  
Influenza A ◽  
Human Macrophages ◽  
Influenza A Virus Infection
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