Adenosine induces cell cycle arrest and apoptosis via cyclinD1/Cdk4 and Bcl-2/Bax pathways in human ovarian cancer cell line OVCAR-3

Tumor Biology ◽  
2013 ◽  
Vol 34 (2) ◽  
pp. 1085-1095 ◽  
Author(s):  
Saeid Shirali ◽  
Mahmoud Aghaei ◽  
Mahdi Shabani ◽  
Mojtaba Fathi ◽  
Majid Sohrabi ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Cell Cycle Arrest ◽  
Cell Line ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Ovarian Cancer ◽  
Human Ovarian Cancer Cell ◽  
Cycle Arrest

scholarly journals Antiproliferative Effects of Selected Chemotherapeutics in Human Ovarian Cancer Cell Line A2780

2012 ◽  
Vol 55 (3) ◽  
pp. 116-124 ◽  
Author(s):  
Kateřina Caltová ◽  
Miroslav Červinka
Keyword(s):  
Cell Cycle ◽  
Ovarian Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Ovarian Cancer ◽  
Human Ovarian Cancer Cell ◽  
Morphological Studies

The aim of our study was to determine the effect of selected cytostatics on a human ovarian cancer cell line A2780 as a model system for ovarian cancer treatment. This cell line is considered cisplatin-sensitive. Panel of tested cytostatics included cisplatin, paclitaxel, carboplatin, gemcitabine, topotecan and etoposide. These cytostatics have a different mechanism of action. To evaluate cytotoxic potential of the tested compounds, the methods measuring various toxicological endpoints were employed including morphological studies, MTT assay, dynamic monitoring of cell proliferation with xCELLigence, cell cycle analysis, caspase 3 activity and expression of proteins involved in cell cycle regulation and cell death. The A270 cell line showed different sensitivity towards the selected cytostatics, the highest cytotoxic effect was associated with paclitaxel and topotecan.

scholarly journals Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS

Oncogene ◽  
2006 ◽  
Vol 25 (25) ◽  
pp. 3547-3556 ◽  
Author(s):  
H Linghu ◽  
M Tsuda ◽  
Y Makino ◽  
M Sakai ◽  
T Watanabe ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Adaptor Protein ◽  
Cancer Cell Line ◽  
Human Ovarian Cancer ◽  
Human Ovarian Cancer Cell ◽  
Malignant Feature

Isolation and characterization of stem-like cells from a human ovarian cancer cell line

2011 ◽  
Vol 363 (1-2) ◽  
pp. 257-268 ◽  
Author(s):  
Lijuan Wang ◽  
Roman Mezencev ◽  
Nathan J. Bowen ◽  
Lilya V. Matyunina ◽  
John F. McDonald
Keyword(s):  
Ovarian Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Ovarian Cancer ◽  
Human Ovarian Cancer Cell ◽  
Isolation And Characterization
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