scholarly journals Renal Complications and Duration of Diabetes: An International Comparison in Persons with Type 1 Diabetes

2021 ◽  
Author(s):  
Mary Dena ◽  
Ann-Marie Svensson ◽  
Katarina Eeg Olofsson ◽  
Laura Young ◽  
Anders Carlson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
International Comparison ◽  
Duration Of Diabetes ◽  
Renal Complications

scholarly journals Clinical significance of intramammary arterial calcifications in diabetic women

2004 ◽  
Vol 61 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Zorica Milosevic ◽  
Jelica Bjekic ◽  
Stanko Radulovic ◽  
Branislav Goldner
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Control Group ◽  
Duration Of Diabetes ◽  
Diabetic Macroangiopathy ◽  
Indirect Sign ◽  
Significant Difference

Background. It is well known that intramammary arterial calcifications diagnosed by mammography as a part of generalized diabetic macroangiopathy may be an indirect sign of diabetes mellitus. Hence, the aim of this study was to determine the incidence of intramammary arterial calcifications, the patient?s age when the calcifications occur, as well as to observe the influence of diabetic polineuropathy, type, and the duration of diabetes on the onset of calcifications, in comparison with nondiabetic women. Methods. Mammographic findings of 113 diabetic female patients (21 with type 1 diabetes and 92 with type 2), as well as of 208 nondiabetic women (the control group) were analyzed in the prospective study. The data about the type of diabetes, its duration, and polineuropathy were obtained using the questionnaire. Statistical differences were determined by Mann-Whitney test. Results. Intramammary arterial calcifications were identified in 33.3% of the women with type 1 diabetes, in 40.2% with type 2, and in 8.2% of the women from the control group, respectively. The differences comparing the women with type 1, as well as type 2 diabetes and the controls were statistically significant (p=0.0001). Women with intramammary arterial calcifications and type 1 diabetes were younger comparing to the control group (median age 52 years, comparing to 67 years of age, p=0.001), while there was no statistically significant difference in age between the women with calcifications and type 2 diabetes (61 years of age) in relation to the control group (p=0.176). The incidence of polineuropathy in diabetic women was higher in the group with intramammary arterial calcifications (52.3%) in comparison to the group without calcifications (26.1%), (p=0.005). The association between intramammary arterial calcifications and the duration of diabetes was not found. Conclusion. The obtained results supported the theory that intramammary arterial calcifications, detected by mammography could serve as markers of co-existing diabetes mellitus and therefore should be specified in radiologic report in case of their early development.

scholarly journals Accelerated Bilateral Cataract Formation as a First Manifestation of Diabetes Mellitus

2013 ◽  
Vol 114 (4) ◽  
pp. 258-262 ◽  
Author(s):  
M. R. Manaviat ◽  
Nasim Oveisi ◽  
A. Zare-Bidoki
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Emergency Room ◽  
Type 1 Diabetes Mellitus ◽  
Cataract Formation ◽  
Bilateral Cataract ◽  
Duration Of Diabetes ◽  
History Of ◽  
New Onset

There is a proved relationship between diabetes mellitus and the cataract formation. The incidence of this is usually related to the duration of diabetes. In this manuscript we report a 15 years old female presented to the emergency room with a 4 hour history of rapid bilateral diminished vision, initially diagnosed with idiopathic cataracts, but after more laboratory evaluations revealed new-onset type 1 diabetes mellitus without ketosis.

Electrocardiographic data of children with type 1 diabetes mellitus

2021 ◽  
pp. 1-5
Author(s):  
Mehmet Türe ◽  
Alper Akın ◽  
Edip Unal ◽  
Ahmet Kan ◽  
Suat Savaş
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Sudden Death ◽  
Type 1 Diabetes Mellitus ◽  
Qt Dispersion ◽  
Control Group ◽  
Haemoglobin A1c ◽  
Duration Of Diabetes ◽  
And Gender

Abstract Background: Adult patients diagnosed with type 1 diabetes mellitus are at risk for ventricular arrhythmias and sudden cardiac death. Aim: The objective of our study is to evaluate the electrocardiographic data of children diagnosed with type 1 diabetes mellitus and to determine the possibility of arrhythmia in order to prevent sudden death. Methods: Electrocardiographic data of 60 patients diagnosed with type 1 diabetes mellitus and 86 controls, who were compatible with the patient group in terms of age and gender, were compared. Results: The duration of diabetes in our patients with type 1 diabetes mellitus was 5.23 ± 1.76 years, and the haemoglobin A1c levels were 9.63% ± 1.75%. The heart rate, QRS, QT maximum, QT dispersion, QTc minimum, QTc maximum, QTc dispersion, Tp-e maximum, Tp-e maximum/QTc maximum and the JTc were significantly higher compared to the control group. There was no significant correlation between the duration of type 1 diabetes mellitus and HbA1c levels and the electrocardiographic data. Conclusion: We attributed the lack of a significant correlation between the duration of type 1 diabetes mellitus and the haemoglobin A1c levels and the electrocardiographic data to the fact that the duration of diabetes was short, since our patients were children. We believe that patients with type 1 diabetes mellitus should be followed up closely in terms of sudden death, as they have electrocardiographic changes that may cause arrhythmias compared to the control group. However, more studies with longer follow-up periods are necessary to support our data.

International comparison of glycaemic control in people with type 1 diabetes: an update and extension

2021 ◽  
Author(s):  
R. Prigge ◽  
J. A. McKnight ◽  
S. H. Wild ◽  
A. Haynes ◽  
T. W. Jones ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycaemic Control ◽  
International Comparison

P4989Peripheral neuropathy and diastolic function are associated with adverse cardiovascular outcome in patients with type 1 diabetes mellitus: results from the thousand & 1 study

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
G M Hansen ◽  
P G Jorgensen ◽  
H U Andersen ◽  
P Rossing ◽  
M T Jensen
Keyword(s):  
Type 1 Diabetes ◽  
Heart Disease ◽  
Diastolic Function ◽  
Cox Regression ◽  
Sensory Threshold ◽  
Duration Of Diabetes ◽  
Increased Risk ◽  
Prediction Of Prognosis ◽  
Risk Engine

Abstract Background Peripheral neuropathy (PN) is a highly prevalent and feared microvascular complication in patients with type 1 diabetes (T1D). Cardiovascular disease (CVD) is the most common cause of mortality in patients with T1D. PN may act as an early indicator of CVD and can potentially contribute to the propagation of atherosclerosis and cause the disease to remain clinically silent into advanced stages. Therefore, identification of T1D patients at risk of CVD is important in assuring timely prevention and treatment. Purpose The purpose of this study was to evaluate the risk of major adverse cardiovascular events (MACE) associated with measures of PN and diastolic function (DF) in patients with T1D and no known heart disease. Furthermore, we tested the additional prognostic value of including PN and DF both alone and in combination, in the validated Steno T1D Risk Engine. Methods Patients with T1D without known heart disease were included from the Steno Diabetes Center Copenhagen. Echocardiography and quantitative testing for PN using biothesiometry to determine sensory vibration threshold were performed. The patients were divided into three categories according to sensory threshold: <20mV, 20–49 mV, and ≥50mV. DF was divided into three categories of E/e': <8, 8–12, and >12. Endpoints was first occurring MACE. Using multivariable Cox regression models adjusting for age, sex, blood pressure, BMI, HbA1c, smoking, alcohol consumption, family history of CVD, eGFR, albuminuria, and duration of diabetes, the association between PN and/or DF and the risk of MACE was analysed. Improvement in prediction of prognosis was assessed with Harrell's C-statistics and compared to Steno T1D Risk Engine. Results A total of 946 patients (51.5% males) with T1D were included. Mean age was 48.4 (SD 14.4) years and mean duration of diabetes was 25 (SD 14.3) years. In the adjusted analysis, which was mutually adjusted for measures of PN and DF, both PN and DF were associated with increased risk of MACE: Sensory threshold ≥50mV vs. <20mV: Hazard Ratio (HR) 2.18 (95% confidence interval [CI]: 1.02–4.64, p=0.044). Threshold 20–49mV vs. <20mV: HR 1.33 (95% CI: 0.77–2.30, p=0.31). Diastolic measurement E/e' >12 vs. E/e' <8: HR 2.31 (95% CI: 1.16–4.59, p=0.017), and E/e' 8–12 vs. E/e' <8: HR 1.70 (95% CI: 1.03–2.82, p=0.038). In combination, a threshold ≥50mV and E/e' >12 vs. <20mV and E7e' <8 was associated with a marked increased risk of MACE: HR 8.59 (95% CI: 2.60–28.4, p<0.001). The addition of E/e' to the Steno T1D Risk Engine improved the prediction of outcome: C-statistic 0.797, (95% CI: 0.758–0.835) vs. 0.785 (95% CI: 0.744–0.825), p<0.001. Conclusion In patients with T1D without known heart disease and with preserved ejection fraction, PN and DF are independently associated with an increased risk of MACE. However, only measures of DF improved the prediction of prognosis when added to clinical risk factors. Acknowledgement/Funding None

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