scholarly journals Three New Heptelidic Acid Derivatives from the Culture of Mushroom Lentinellus ursinus

2018 ◽  
Vol 8 (5) ◽  
pp. 355-360 ◽  
Author(s):  
Li Liu ◽  
Jun-Jie Han ◽  
Tian-Shun Xu ◽  
Rui-Xing Liu ◽  
Li Bao ◽  
...  
Keyword(s):  
Heptelidic Acid ◽  
Lentinellus Ursinus

scholarly journals Structure of heptelidic acid, a new sesquiterpene antibiotic from fungi.

1980 ◽  
Vol 33 (5) ◽  
pp. 525-526 ◽  
Author(s):  
YASUHIRO ITOH ◽  
SHUJI TAKAHASHI ◽  
TATSUO HANEISHI ◽  
MAMORU ARAI
Keyword(s):  
Heptelidic Acid

scholarly journals 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Shan-Ting Liao ◽  
Chao Han ◽  
Ding-Qiao Xu ◽  
Xiao-Wei Fu ◽  
Jun-Song Wang ◽  
...  
Keyword(s):  
Aerobic Glycolysis ◽  
Glycolytic Enzyme ◽  
Cysteine Residue ◽  
Glycolytic Flux ◽  
Flux Analysis ◽  
Activated Macrophages ◽  
A Cell ◽  
Anti Inflammatory ◽  
Heptelidic Acid

Abstract Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has been reported to regulate macrophage function, but its precise mechanism is not clear. Here, we show that 4-octyl itaconate (4-OI, a cell-permeable itaconate derivative) directly alkylates cysteine residue 22 on the glycolytic enzyme GAPDH and decreases its enzyme activity. Glycolytic flux analysis by U13C glucose tracing provides evidence that 4-OI blocks glycolytic flux at GAPDH. 4-OI thereby downregulates aerobic glycolysis in activated macrophages, which is required for its anti-inflammatory effects. The anti-inflammatory effects of 4-OI are replicated by heptelidic acid, 2-DG and reversed by increasing wild-type (but not C22A mutant) GAPDH expression. 4-OI protects against lipopolysaccharide-induced lethality in vivo and inhibits cytokine release. These findings show that 4-OI has anti-inflammatory effects by targeting GAPDH to decrease aerobic glycolysis in macrophages.

Total synthesis of (+)-heptelidic acid

1996 ◽  
Vol 4 ◽  
pp. S110 ◽  
Author(s):  
W. Fleischhacker ◽  
G. Riehs ◽  
E. Urban
Keyword(s):  
Total Synthesis ◽  
Heptelidic Acid

scholarly journals Heme-dependent Radical Generation from Antimalarial Fungal Metaholites, Radicicol and Heptelidic acid.

1998 ◽  
Vol 51 (4) ◽  
pp. 451-453 ◽  
Author(s):  
YOSHITAKE TANAKA ◽  
FANG FANG ◽  
CHENG GANG ZHANG ◽  
XIAN WU ZHANG ◽  
SATOSHI OMURA
Keyword(s):  
Radical Generation ◽  
Heptelidic Acid

scholarly journals Deletion of the Trichoderma virens NRPS, Tex7, induces accumulation of the anti-cancer compound heptelidic acid

2020 ◽  
Vol 529 (3) ◽  
pp. 672-677
Author(s):  
James T. Taylor ◽  
Prasun K. Mukherjee ◽  
Lorraine S. Puckhaber ◽  
Karuna Dixit ◽  
Tatyana I. Igumenova ◽  
...  
Keyword(s):  
Trichoderma Virens ◽  
Anti Cancer ◽  
Heptelidic Acid

ChemInform Abstract: EPC Synthesis of (+)-Heptelidic Acid.

ChemInform ◽  
2010 ◽  
Vol 28 (33) ◽  
pp. no-no
Author(s):  
G. RIEHS ◽  
E. URBAN
Keyword(s):  
Heptelidic Acid

EPC synthesis of (+)-heptelidic acid

1997 ◽  
Vol 128 (3) ◽  
pp. 281-289 ◽  
Author(s):  
G. Riehs ◽  
E. Urban
Keyword(s):  
Heptelidic Acid
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