Identification of a gene cluster for biosynthesis of the sesquiterpene antibiotic, heptelidic acid, in Aspergillus oryzae

2018 ◽  
Vol 83 (8) ◽  
pp. 1506-1513 ◽  
Author(s):  
Yasutomo Shinohara ◽  
Ikuko Nishimura ◽  
Yasuji Koyama
Keyword(s):  
Gene Cluster ◽  
Aspergillus Oryzae ◽  
Heptelidic Acid

scholarly journals Heterologous Biosynthesis and Genomics-Driven Derivatization of Fungal Bioactive Sesterterpenoid Variecolin

2021 ◽  
Author(s):  
Dexiu Yan ◽  
Jemma Arakelyan ◽  
Teng Wan ◽  
Tsz Ki Chan ◽  
Dohyun Ahn ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Anticancer Activity ◽  
Gene Cluster ◽  
Aspergillus Oryzae ◽  
Biosynthetic Gene Cluster ◽  
Heterologous Production ◽  
Biosynthetic Gene ◽  
Aspergillus Aculeatus ◽  
Heterologous Biosynthesis

The biosynthetic gene cluster of fungal bioactive sesterterpenoids, variecolin (1) and variecolactone (2), was identified in Aspergillus aculeatus ATCC 16872. Heterologous production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 VrcB. Intriguingly, the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues, one of which exhibited potent anticancer activity comparable to that of 1.

Efficient Reconstitution of Basidiomycota Diterpene Erinacine Gene Cluster in Ascomycota Host Aspergillus oryzae Based on Genomic DNA Sequences

2019 ◽  
Vol 141 (39) ◽  
pp. 15519-15523 ◽  
Author(s):  
Chengwei Liu ◽  
Atsushi Minami ◽  
Taro Ozaki ◽  
Jing Wu ◽  
Hirokazu Kawagishi ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Aspergillus Oryzae ◽  
Dna Sequences ◽  
Genomic Dna

Aspergillus oryzae strains with a large deletion of the aflatoxin biosynthetic homologous gene cluster differentiated by chromosomal breakage

2006 ◽  
Vol 72 (2) ◽  
pp. 339-345 ◽  
Author(s):  
Yun-Hae Lee ◽  
Mihoko Tominaga ◽  
Risa Hayashi ◽  
Kazutoshi Sakamoto ◽  
Osamu Yamada ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Aspergillus Oryzae ◽  
Large Deletion ◽  
Homologous Gene ◽  
Chromosomal Breakage

Construction of a Citrinin Gene Cluster Expression System in Heterologous Aspergillus oryzae

2008 ◽  
Vol 106 (5) ◽  
pp. 466-472 ◽  
Author(s):  
Kanae Sakai ◽  
Hiroshi Kinoshita ◽  
Takeo Shimizu ◽  
Takuya Nihira
Keyword(s):  
Gene Cluster ◽  
Aspergillus Oryzae ◽  
Expression System

scholarly journals Furan, phenolic, and heptelidic acid derivatives produced by Aspergillus oryzae

2016 ◽  
Vol 25 (5) ◽  
pp. 1259-1264 ◽  
Author(s):  
Minji Lee ◽  
Jeong-Yong Cho ◽  
Yu Geon Lee ◽  
Hyoung Jae Lee ◽  
Seong-Il Lim ◽  
...  
Keyword(s):  
Aspergillus Oryzae ◽  
Heptelidic Acid

Analysis of aflatoxin biosynthetic pathway gene cluster of Aspergillus oryzae RIB strains

2003 ◽  
Vol 2003 (Suppl3) ◽  
pp. 345-348
Author(s):  
Mihoko TOMINAGA ◽  
Yun Hae LEE ◽  
Risa HAYASHI ◽  
Osamu YAMADA ◽  
Kazutoshi SAKAMOTO ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Aspergillus Oryzae ◽  
Biosynthetic Pathway ◽  
Pathway Gene
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