Development of a new highly standardized and granulated extract from Monascus purpureus with a high content of monacolin K and KA and free of inactive secondary monacolins and citrinin

Nutrafoods ◽  
2015 ◽  
Vol 14 (4) ◽  
pp. 197-205 ◽  
Author(s):  
Giulia Nannoni ◽  
Alessandro Alì ◽  
Francesco Di Pierro
Keyword(s):  
Monascus Purpureus ◽  
Monacolin K

scholarly journals Elevated yield of Monacolin K in Monascus purpureus by fungal elicitor and mutagenesis of UV and LiCl

2011 ◽  
Vol 44 (4) ◽  
pp. 377-382 ◽  
Author(s):  
Jia-Long Sun ◽  
Xiao Zou ◽  
Ai-Ying Liu ◽  
Tang-Fu Xiao
Keyword(s):  
Fungal Elicitor ◽  
Monascus Purpureus ◽  
Monacolin K

scholarly journals Improving the monacolin K to citrinin production ratio in red yeast rice by an X-ray-induced mutant strain of Monascus purpureus

2018 ◽  
Vol 99 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Apinun Kanpiengjai ◽  
Rapeepun Mahawan ◽  
Prodpran Pengnoi ◽  
Saisamorn Lumyong ◽  
Chartchai Khanongnuch
Keyword(s):  
Mutant Strain ◽  
Monascus Purpureus ◽  
Red Yeast Rice ◽  
Monacolin K ◽  
X Ray ◽  
Production Ratio ◽  
Red Yeast ◽  
Induced Mutant

Investigation of biosynthetic mechanisms of Monacolin K and pigments in Monascus purpureus based on transcriptomic analysis

2019 ◽  
Author(s):  
Zhanxia Liu ◽  
Bin Wang ◽  
Yuchen Zhang ◽  
Lei Jiang ◽  
Chenxi Dai ◽  
...  
Keyword(s):  
Transcriptomic Analysis ◽  
Monascus Purpureus ◽  
Monacolin K

scholarly journals Comparative study of red yeast rice with high monacolin K, low citrinin concentration and pigments in white rice and brown rice

2019 ◽  
Vol 37 (No. 1) ◽  
pp. 75-80 ◽  
Author(s):  
Pramuan Saithong ◽  
Wanida Tewaruth Chitisankul ◽  
Supachi Nitipan
Keyword(s):  
Comparative Study ◽  
Brown Rice ◽  
Monascus Purpureus ◽  
Red Yeast Rice ◽  
Monacolin K ◽  
Constant Weight ◽  
Fermentation Time ◽  
White Rice ◽  
Red Yeast ◽  
Target Strain

Growth pigments and metabolites of monacolin K and citrinin were compared for Monascus purpureus during 14-day solid-state ermentation on white rice and brown rice (Chai-Nart cultivar). Monascus purpureus IFRPD 4046 was selected as the target strain which produced the  ighesth monacolin K content and the lowest citrinin content. Optimum fermentation conditions regarding moisture content, temperature and fermentation time were determined. A comparative study showed that monacolin K production in white rice was about twice higher than in brown rice. At the optimum conditions, concentrations of monacolin K dried at 55°C to constant weight were 132.98 and 66.48 mg/100 g in white rice and brown rice, respectively while citrinin was not detected. Results revealed that the IFRPD 4046 strain has a potential to produce red yeast rice with higher monacolin K in white rice than<br />in brown rice with low citrinin content.

Overexpression of Monacolin K Biosynthesis Genes in the Monascus purpureus Azaphilone Polyketide Pathway

2019 ◽  
Vol 67 (9) ◽  
pp. 2563-2569 ◽  
Author(s):  
Chan Zhang ◽  
Jian Liang ◽  
Anan Zhang ◽  
Shuai Hao ◽  
Han Zhang ◽  
...  
Keyword(s):  
Monascus Purpureus ◽  
Monacolin K

scholarly journals iTRAQ-Based Quantitative Proteomic Analysis Reveals Changes in Metabolite Biosynthesis in Monascus purpureus in Response to a Low-Frequency Magnetic Field

Toxins ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 440 ◽  
Author(s):  
Jialan Zhang ◽  
Yingbao Liu ◽  
Li Li ◽  
Mengxiang Gao
Keyword(s):  
Protein Level ◽  
Low Frequency ◽  
Absolute Quantification ◽  
Differentially Expressed ◽  
Monascus Purpureus ◽  
Monacolin K ◽  
Yellow Orange ◽  
Frequency Magnetic Field ◽  
Isobaric Tags ◽  
Control Protein

Background: Low-frequency magnetic fields (LF-MFs) dampen the citrinin output by Monascus purpureus in fermentations. The influence of LF-MFs on biosynthesis by M. purpureus was evaluated at the protein level. Methods: Cultures were treated with a 1.6-mT MF from day 0 to day 2 of incubation, and secondary metabolite production was evaluated on the day 12 of incubation. All proteins were extracted from M. purpureus mycelia and subjected to isobaric tags for relative and absolute quantification (iTRAQ) labeling and subsequent liquid chromatography/mass spectrometry (LC-MS/MS) analysis on day 6 of fermentation. Results: There was no difference in biomass between the treated samples and the control. Citrinin production was 46.7% lower, and the yields of monacolin K and yellow, orange, and red pigment were 29.3%, 31.3%, 41.7%, and 40.3% higher, respectively, in the exposed samples compared to the control. Protein expression in M. purpureus under LF-MF treatment was quantified using iTRAQ technology. Of 2031 detected proteins, 205 were differentially expressed. The differentially-expressed proteins were subjected to Gene Ontology (GO) functional annotation and statistical analysis, which revealed that they mainly refer to biological metabolism, translation, antioxidant, transport and defense pathways. Among all the tagged proteins, emphasis was placed on the analysis of those involved in the synthesis of citrinin, pigment and monacolin K was emphasized. Conclusions: LF-MFs affected Monascus secondary metabolism at the protein level, and aggregate data for all the protein profiles in LF-MF-treated Monascus was obtained.

Biofortification of Indian rice (IR-532-E-576) with monacolin K by RSM optimisation using Monascus purpureus MTCC 1090

Nutrafoods ◽  
2012 ◽  
Vol 11 (2) ◽  
pp. 49-54 ◽  
Author(s):  
Aiyalu Rajasekaran ◽  
Muthusamy Kalaivani
Keyword(s):  
Monascus Purpureus ◽  
Monacolin K

Effect of arginine supplementation on Monacolin K yield of Monascus purpureus

2021 ◽  
pp. 104252
Author(s):  
Chan Zhang ◽  
Mengxue Chen ◽  
Yueming Zang ◽  
Haijiao Wang ◽  
Xinyu Wei ◽  
...  
Keyword(s):  
Monascus Purpureus ◽  
Monacolin K ◽  
Arginine Supplementation
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