The frequency of ALSFRS-R reversals and plateaus in patients with limb-onset amyotrophic lateral sclerosis: a cohort study

2022 ◽  
Author(s):  
Nan Hu ◽  
Dongchao Shen ◽  
Xunzhe Yang ◽  
Liying Cui ◽  
Mingsheng Liu
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Lateral Sclerosis ◽  
Limb Onset

scholarly journals Physical activity and risk of Amyotrophic Lateral Sclerosis in a prospective cohort study

2016 ◽  
Vol 31 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Valentina Gallo ◽  
Nicola Vanacore ◽  
H. Bas Bueno-de-Mesquita ◽  
Roel Vermeulen ◽  
Carol Brayne ◽  
...  
Keyword(s):  
Physical Activity ◽  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lateral Sclerosis

The Relevance of Amyotrophic Lateral Sclerosis Clinical Presentation: A Cohort Study

CHEST Journal ◽  
2014 ◽  
Vol 145 (3) ◽  
pp. 461A
Author(s):  
Artur Vale ◽  
Ana Ferreira ◽  
Elsa Matos ◽  
Duarte Rocha ◽  
Bebiana Conde
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Clinical Presentation ◽  
Lateral Sclerosis

Relationship between EMG-detected and ultrasound-detected fasciculations in amyotrophic lateral sclerosis: A prospective cohort study

2020 ◽  
Vol 131 (1) ◽  
pp. 259-264 ◽  
Author(s):  
Kota Bokuda ◽  
Toshio Shimizu ◽  
Hideki Kimura ◽  
Ryo Morishima ◽  
Tsutomu Kamiyama ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lateral Sclerosis

scholarly journals Serial assessment of iron in the motor cortex in limb-onset amyotrophic lateral sclerosis using quantitative susceptibility mapping

2020 ◽  
Vol 10 (7) ◽  
pp. 1465-1476
Author(s):  
Anjan Bhattarai ◽  
Zhaolin Chen ◽  
Phillip G. D. Ward ◽  
Paul Talman ◽  
Susan Mathers ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Lateral Sclerosis ◽  
Limb Onset

scholarly journals Relative preservation of triceps over biceps strength in upper limb-onset ALS: the ‘split elbow’

2019 ◽  
Vol 90 (7) ◽  
pp. 730-733 ◽  
Author(s):  
Roaya Khalaf ◽  
Sarah Martin ◽  
Cathy Ellis ◽  
Rachel Burman ◽  
Jemeen Sreedharan ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Upper Limb ◽  
Selective Vulnerability ◽  
Relative Strength ◽  
Rank Test ◽  
Cortical Representation ◽  
Signed Rank Test ◽  
South East England ◽  
Lateral Sclerosis ◽  
Limb Onset

ObjectiveAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the motor system. The split hand sign in ALS refers to observed preferential weakness of the lateral hand muscles, which is unexplained. One possibility is larger cortical representation of the lateral hand compared with the medial. Biceps strength is usually preserved relative to triceps in neurological conditions, but biceps has a larger cortical representation and might be expected to show preferential weakness in ALS.MethodsUsing the South-East England Register for Amyotrophic Lateral Sclerosis, we performed a retrospective longitudinal cohort study and extracted the modified Medical Research Council (MRC) muscle strength score for biceps and triceps in patients with a diagnosis of upper limb-onset ALS in the 19-year period 1996–2015. A Wilcoxon signed-rank test was used to assess the relative strength of the muscles within the total sum of the upper limbs involved in the study.ResultsThere were 659 people with upper limb onset of weakness. In 215 there were insufficient data to perform the analysis, and a further 33 were excluded for other reasons, leaving 411 for analysis. Biceps was stronger than triceps in 87 limbs, and triceps was stronger than biceps in 258 limbs, with no difference seen in the remaining 477. Triceps strength scores (mean rank=186.1) were higher than ipsilateral biceps strength scores (mean rank=134.2), Z=−10.1, p<0.001 (two-tailed).ConclusionTriceps strength is relatively preserved compared with biceps in ALS. This is consistent with a broadly corticofugal hypothesis of selective vulnerability, in which susceptibility might be associated with larger cortical representation.

Brain injury and neurologic sequelae: A cohort study of dementia, parkinsonism, and amyotrophic lateral sclerosis

Neurology ◽  
1991 ◽  
Vol 41 (10) ◽  
pp. 1554-1554 ◽  
Author(s):  
D. B. Williams ◽  
J. F. Annegers ◽  
E. Kokmen ◽  
P. C. O'Brien ◽  
L. T. Kurland
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Cohort Study ◽  
Brain Injury ◽  
Neurologic Sequelae ◽  
Lateral Sclerosis
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