scholarly journals Cryotherapy for Intra- and Perianal High-Grade Squamous Intraepithelial Lesions in HIV-Positive Men who have Sex with Men

2017 ◽  
Vol 19 (1) ◽  
pp. 127-132 ◽  
Author(s):  
Matthijs L. Siegenbeek van Heukelom ◽  
Karien C. M. Gosens ◽  
Jan M. Prins ◽  
Henry J. C. de Vries
Keyword(s):  
Hiv Positive ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men

scholarly journals Virological and serological predictors of anal high-grade squamous intraepithelial lesions among HIV-positive men who have sex with men

2018 ◽  
Vol 5 ◽  
pp. S9 ◽  
Author(s):  
Elske Marra ◽  
Matthijs L. Siegenbeek van Heukelom ◽  
Annemiek Leeman ◽  
Tim Waterboer ◽  
Chris J.L.M. Meijer ◽  
...  
Keyword(s):  
Hiv Positive ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men

Response factors associated with electrocautery treatment of intra-anal high-grade squamous intraepithelial lesions in a population of HIV-positive men who have sex with men

2021 ◽  
pp. 095646242110170
Author(s):  
Irene Fuertes ◽  
Ross Cranston ◽  
Elisa de Lazzari ◽  
Leonardo Rodriguez-Carunchio ◽  
José L Blanco
Keyword(s):  
Response To Treatment ◽  
Hiv Positive ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Response Factors ◽  
Serious Adverse Events ◽  
Anal Squamous Cell Carcinoma ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men

Background: Ablative treatment of anal high-grade squamous intraepithelial lesions (HSIL) reduces the risk of progression to anal squamous cell carcinoma. Objectives: To identify factors that influence the response to treatment of anal HSIL by electrocautery ablation (ECA) in a population of HIV-positive men who have sex with men (MSM). Design: Retrospective study of ECA treatment response in a prospectively followed anal dysplasia cohort. HIV-positive MSM diagnosed with anal HSIL were included. Demographic and HIV data were recorded. Response to treatment was assessed by biopsy after at least 18 months of follow-up. Results: One hundred and twenty-eight HSILs in 91 men were included in this study. The overall response rate at 18 months was 70.3%. The number of electrocautery sessions required (2 ECA sessions vs 1: adjusted odds ratio [aOR] = 0.36 (95%CI 0.13-1.01); >=3 sessions vs 1: aOR = 0.10 (95%CI 0.04-0.29); p < 0.001]) and the history of previous HPV-related anal pathology (previous anal lesions vs no previous lesions AOR = 2.83 (95%CI 1.14-7.02), p = 0.024) were independently associated with response at 18 months. No serious adverse events were reported. Conclusions: Consideration should be given to alternative therapies in patients with unresolved HSIL after 1 ECA treatment.

scholarly journals Determinants of high-grade anal intraepithelial lesions in HIV-positive men having sex with men

2018 ◽  
Vol 5 ◽  
pp. S3
Author(s):  
Isabelle Etienney ◽  
Laurent Siproudhis ◽  
Lionel Piroth ◽  
Isabelle Poizot-Martin ◽  
Sylvie Radenne ◽  
...  
Keyword(s):  
Hiv Positive ◽  
High Grade ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men

Topical Application of Trichloroacetic Acid Is Efficacious for the Treatment of Internal Anal High-Grade Squamous Intraepithelial Lesions in HIV-Positive Men

2014 ◽  
Vol 41 (7) ◽  
pp. 420-426 ◽  
Author(s):  
Ross D. Cranston ◽  
Jonathan R. Baker ◽  
Yimeng Liu ◽  
Lu Wang ◽  
Esther Elishaev ◽  
...  
Keyword(s):  
Topical Application ◽  
Trichloroacetic Acid ◽  
Hiv Positive ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men

Anal cytological abnormalities are poor predictors of high-grade intraepithelial neoplasia amongst HIV-positive men who have sex with men

Sexual Health ◽  
2013 ◽  
Vol 10 (1) ◽  
pp. 9 ◽  
Author(s):  
Leon P. Botes ◽  
Sarah Pett ◽  
Andrew Carr ◽  
Debbie Marriott ◽  
David A. Cooper ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Hiv Positive ◽  
High Grade ◽  
Histological Findings ◽  
Squamous Intraepithelial Lesions ◽  
Atypical Cells ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
General Community ◽  
Undetermined Significance

Background Although anal squamous cell carcinomas (ASCC) are rare in the general community, rates of ASCC among HIV-positive men who have sex with men (MSM) approach those of major cancers in the general community, such as colorectal and lung cancers. Anal cytology and high-resolution anoscopy (HRA) have been proposed as methods for the diagnosis of high-grade anal intraepithelial neoplasia (HGAIN), the precursor of ASCC. To determine the prevalence of anal disease among HIV-positive MSM, we investigated anal cytological and histological findings in men from a large HIV clinic in Sydney, Australia. Methods: This was a single-centre study conducted between October 2008 and January 2010. Participants self-collected cytology specimens, and those yielding abnormal cytology results of atypical cells of undetermined significance, atypical cells of undetermined significance – possibly high-grade (ASC-H) and high-grade squamous intraepithelial lesions (HSIL) were offered HRA. In addition, of those yielding low-grade squamous intraepithelial lesions results, a systematically selected group (25%) were offered HRA. Results: Of the 1339 HIV-positive MSM who attended the clinic during the study period, 291 (31.8%) were finally included in the study, 262 yielded technically satisfactory cytological results and 101 (36.7%) participants underwent HRA. HGAIN was identified in 55 (54.5%) of the 101 men undergoing HRA. HGAIN was diagnosed in 28 (52.7%) without cytological ASC-H or HSIL results. Conclusions: Despite the poor correlation between anal cytological and histological findings, high levels of HGAIN were identified in HIV-positive MSM attending this clinical service.

Detection Rate of High-Grade Squamous Intraepithelial Lesions as a Quality Assurance Metric for High-Resolution Anoscopy in HIV-Positive Men

2018 ◽  
Vol 61 (7) ◽  
pp. 780-786 ◽  
Author(s):  
Matthijs L. Siegenbeek van Heukelom ◽  
Elske Marra ◽  
Irina Cairo ◽  
Arne Van Eeden ◽  
Maarten F. Schim van der Loeff ◽  
...  
Keyword(s):  
Quality Assurance ◽  
High Resolution ◽  
Detection Rate ◽  
Hiv Positive ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men

scholarly journals Use of Human Papillomavirus DNA, E6/E7 mRNA, and p16 Immunocytochemistry to Detect and Predict anal High-Grade Squamous Intraepithelial Lesions in HIV-Positive and HIV-Negative Men Who Have Sex with Men

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e78291 ◽  
Author(s):  
Nittaya Phanuphak ◽  
Nipat Teeratakulpisarn ◽  
Somboon Keelawat ◽  
Tippawan Pankam ◽  
Jiranuwat Barisri ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hiv Positive ◽  
High Grade ◽  
Squamous Intraepithelial Lesions ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Papillomavirus Dna ◽  
Hiv Negative

scholarly journals Determinants of high-grade anal intraepithelial lesions in HIV-positive men having sex with men

AIDS ◽  
2018 ◽  
pp. 1 ◽  
Author(s):  
Gary M. Clifford ◽  
Laurent Siproudhis ◽  
Lionel Piroth ◽  
Isabelle Poizot-Martin ◽  
Sylvie Radenne ◽  
...  
Keyword(s):  
Hiv Positive ◽  
High Grade ◽  
Sex With Men ◽  
Intraepithelial Lesions ◽  
Hiv Positive Men
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