scholarly journals Second-Generation Antipsychotic Drugs for Patients with Schizophrenia: Systematic Literature Review and Meta-analysis of Metabolic and Cardiovascular Side Effects

2021 ◽  
Author(s):  
Carla Rognoni ◽  
Arianna Bertolani ◽  
Claudio Jommi
Keyword(s):  
Side Effects ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Antipsychotic Drugs ◽  
Second Generation ◽  
Meta Analysis ◽  
Cardiovascular Side Effects ◽  
Second Generation Antipsychotic

scholarly journals Second-Generation Antipsychotic Drugs and Extrapyramidal Side Effects: A Systematic Review and Meta-analysis of Head-to-Head Comparisons

2010 ◽  
Vol 38 (1) ◽  
pp. 167-177 ◽  
Author(s):  
Christine Rummel-Kluge ◽  
Katja Komossa ◽  
Sandra Schwarz ◽  
Heike Hunger ◽  
Franziska Schmid ◽  
...  
Keyword(s):  
Systematic Review ◽  
Side Effects ◽  
Antipsychotic Drugs ◽  
Second Generation ◽  
Meta Analysis ◽  
Extrapyramidal Side Effects ◽  
Second Generation Antipsychotic

scholarly journals Second-generation antipsychotic drugs and short-term somatic serious adverse events: a systematic review and meta-analysis

2019 ◽  
Vol 6 (9) ◽  
pp. 753-765 ◽  
Author(s):  
Johannes Schneider-Thoma ◽  
Orestis Efthimiou ◽  
Irene Bighelli ◽  
Carola Dörries ◽  
Maximilian Huhn ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Antipsychotic Drugs ◽  
Second Generation ◽  
Meta Analysis ◽  
Short Term ◽  
Serious Adverse Events ◽  
Second Generation Antipsychotic

scholarly journals Metabolic Side-Effects of the Novel Second-Generation Antipsychotic Drugs Asenapine and Iloperidone: A Comparison with Olanzapine

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53459 ◽  
Author(s):  
Heidi N. Boyda ◽  
Ric M. Procyshyn ◽  
Catherine C. Y. Pang ◽  
Erin Hawkes ◽  
Daniel Wong ◽  
...  
Keyword(s):  
Side Effects ◽  
Antipsychotic Drugs ◽  
Second Generation ◽  
The Novel ◽  
Metabolic Side Effects ◽  
Second Generation Antipsychotic

Metabolic side effects of second generation antipsychotic drugs in adolescents

2013 ◽  
Author(s):  
Iuliana Dobrescu ◽  
Florina Rad ◽  
Gianina Cristina Anghel ◽  
Cristina Petrescu-Ghenea ◽  
Carmen Trutescu
Keyword(s):  
Side Effects ◽  
Antipsychotic Drugs ◽  
Second Generation ◽  
Metabolic Side Effects ◽  
Second Generation Antipsychotic

scholarly journals A comparison of the metabolic side-effects of the second-generation antipsychotic drugs risperidone and paliperidone in animal models

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246211
Author(s):  
Heidi N. Boyda ◽  
Ric M. Procyshyn ◽  
Lurdes Tse ◽  
Jessica W. Y. Yuen ◽  
William G. Honer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Side Effects ◽  
Glucose Tolerance ◽  
Antipsychotic Drugs ◽  
Second Generation ◽  
Fasting Glucose ◽  
Metabolic Effects ◽  
Metabolic Side Effects ◽  
Second Generation Antipsychotic ◽  
Dose Dependent

Background The second generation antipsychotic drugs represent the most common form of pharmacotherapy for schizophrenia disorders. It is now well established that most of the second generation drugs cause metabolic side-effects. Risperidone and its active metabolite paliperidone (9-hydroxyrisperidone) are two commonly used antipsychotic drugs with moderate metabolic liability. However, there is a dearth of preclinical data that directly compares the metabolic effects of these two drugs, using sophisticated experimental procedures. The goal of the present study was to compare metabolic effects for each drug versus control animals. Methods Adult female rats were acutely treated with either risperidone (0.1, 0.5, 1, 2, 6 mg/kg), paliperidone (0.1, 0.5, 1, 2, 6 mg/kg) or vehicle and subjected to the glucose tolerance test; plasma was collected to measure insulin levels to measure insulin resistance with HOMA-IR. Separate groups of rats were treated with either risperidone (1, 6 mg/kg), paliperidone (1, 6 mg/kg) or vehicle, and subjected to the hyperinsulinemic euglycemic clamp. Results Fasting glucose levels were increased by all but the lowest dose of risperidone, but only with the highest dose of paliperidone. HOMA-IR increased for both drugs with all but the lowest dose, while the three highest doses decreased glucose tolerance for both drugs. Risperidone and paliperidone both exhibited dose-dependent decreases in the glucose infusion rate in the clamp, reflecting pronounced insulin resistance. Conclusions In preclinical models, both risperidone and paliperidone exhibited notable metabolic side-effects that were dose-dependent. Differences between the two were modest, and most notable as effects on fasting glucose.

Second-Generation Antipsychotic Drugs in Anorexia Nervosa: A Meta-Analysis of Randomized Controlled Trials

2015 ◽  
Vol 84 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Markus Dold ◽  
Martin Aigner ◽  
Megan Klabunde ◽  
Janet Treasure ◽  
Siegfried Kasper
Keyword(s):  
Anorexia Nervosa ◽  
Randomized Controlled Trials ◽  
Antipsychotic Drugs ◽  
Second Generation ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Second Generation Antipsychotic
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