Antipsychotic Drug Exposure and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis of Observational Studies

Drug Safety ◽  
2014 ◽  
Vol 37 (2) ◽  
pp. 79-90 ◽  
Author(s):  
Corrado Barbui ◽  
Valentino Conti ◽  
Andrea Cipriani
Keyword(s):  
Systematic Review ◽  
Venous Thromboembolism ◽  
Antipsychotic Drug ◽  
Observational Studies ◽  
Drug Exposure ◽  
Meta Analysis

Antipsychotic drug exposure and risk of pneumonia: a systematic review and meta-analysis of observational studies

2015 ◽  
Vol 24 (8) ◽  
pp. 812-820 ◽  
Author(s):  
Michela Nosè ◽  
Elisabetta Recla ◽  
Gianluca Trifirò ◽  
Corrado Barbui
Keyword(s):  
Systematic Review ◽  
Antipsychotic Drug ◽  
Observational Studies ◽  
Drug Exposure ◽  
Meta Analysis

scholarly journals Does antipsychotic drug use increase the risk of long term mortality? A systematic review and meta-analysis of observational studies

Oncotarget ◽  
2018 ◽  
Vol 9 (19) ◽  
pp. 15101-15110 ◽  
Author(s):  
Chunsong Yang ◽  
Zilong Hao ◽  
Jinhui Tian ◽  
Wei Zhang ◽  
Wenting Li ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Use ◽  
Antipsychotic Drug ◽  
Observational Studies ◽  
Meta Analysis ◽  
Long Term Mortality

scholarly journals Association between progestin-only contraceptive use and cardiometabolic outcomes: A systematic review and meta-analysis

2018 ◽  
Vol 25 (10) ◽  
pp. 1042-1052 ◽  
Author(s):  
Marija Glisic ◽  
Sara Shahzad ◽  
Stergiani Tsoli ◽  
Mahmuda Chadni ◽  
Eralda Asllanaj ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Systematic Review ◽  
Venous Thromboembolism ◽  
Observational Studies ◽  
Contraceptive Use ◽  
Meta Analysis ◽  
Relative Risks ◽  
Increased Risk ◽  
Stratified Analysis ◽  
The Impact

Aims The association between progestin-only contraceptive (POC) use and the risk of various cardiometabolic outcomes has rarely been studied. We performed a systematic review and meta-analysis to determine the impact of POC use on cardiometabolic outcomes including venous thromboembolism, myocardial infarction, stroke, hypertension and diabetes. Methods and results Nineteen observational studies (seven cohort and 12 case–control) were included in this systematic review. Of those, nine studies reported the risk of venous thromboembolism, six reported the risk of myocardial infarction, six reported the risk of stroke, three reported the risk of hypertension and two studies reported the risk of developing diabetes with POC use. The pooled adjusted relative risks (RRs) for venous thromboembolism, myocardial infarction and stroke for oral POC users versus non-users based on the random effects model were 1.06 (95% confidence interval (CI) 0.70–1.62), 0.98 (95% CI 0.66–1.47) and 1.02 (95% CI 0.72–1.44), respectively. Stratified analysis by route of administration showed that injectable POC with a RR of 2.62 (95% CI 1.74–3.94), but not oral POCs (RR 1.06, 95% CI 0.7–1.62), was associated with an increased risk of venous thromboembolism. A decreased risk of venous thromboembolism in a subgroup of women using an intrauterine levonorgestrel device was observed with a RR of 0.53 (95% CI 0.32–0.89). No effect of POC use on blood pressure was found, but there was an indication for an increased risk of diabetes with injectable POCs, albeit non-significant. Conclusions This systematic review and meta-analysis suggests that oral POC use is not associated with an increased risk of developing various cardiometabolic outcomes, whereas injectable POC use might increase the risk of venous thromboembolism.

scholarly journals Antipsychotic drug exposure and risk of myocardial infarction

2016 ◽  
Vol 26 (1) ◽  
pp. 18-21 ◽  
Author(s):  
C. Barbui ◽  
C. Gastaldon ◽  
D. Papola ◽  
G. Ostuzzi
Keyword(s):  
Myocardial Infarction ◽  
Systematic Review ◽  
Observational Studies ◽  
Antipsychotic Drugs ◽  
Drug Exposure ◽  
Meta Analysis ◽  
Antipsychotic Agents ◽  
Clinical Implications ◽  
Everyday Clinical Practice ◽  
Recent Systematic Review

Patients experiencing psychoses and in need of antipsychotic agents may be exposed to a higher risk of myocardial infarction (MI) than the general population. As there have been no randomised studies investigating this association, a recent systematic review and meta-analysis included all observational studies that compared the incidence of MI among patients receiving antipsychoticsv. no treatment. It found nine studies and calculated that the odds (risk) for developing MI were 1.88-fold higher in antipsychotic users compared with individuals who had not taken antipsychotic drugs. In this commentary, the results of this systematic review are discussed in view of their clinical implications for everyday clinical practice.

Abstract P227: Diabetes Mellitus and Venous Thromboembolism: A Systematic Review and Meta-analysis

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Elizabeth J Bell ◽  
Aaron R Folsom ◽  
Pamela L Lutsey ◽  
Elizabeth Selvin ◽  
Mary Cushman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Venous Thromboembolism ◽  
Observational Studies ◽  
Meta Analysis ◽  
Diabetes Mellitus Type 1 ◽  
Vein Thrombosis ◽  
Increased Risk ◽  
Study Heterogeneity ◽  
Control Of Diabetes

Introduction: Reported associations of diabetes with venous thromboembolism (VTE) are inconsistent. We conducted a systematic review and meta-analysis to quantify the association between diabetes mellitus (type 1 or 2) and VTE (deep vein thrombosis or pulmonary embolism). Methods: A systematic review of observational studies was conducted using PubMed, Web of Science, and CINAHL through Dec 31, 2012. Additional studies were identified by contacting experts and through manual review of reference lists of review articles and articles eligible for the present study. We abstracted information on relative risk (RR) estimates and pooled these data using a random-effects model. We queried authors of papers that did not adjust for important confounders to request controlled RR estimates. Results: We identified 10 studies (N participants: 240,940; 7 cohort, 3 case-control: Heit, Lidegaard, and Poulter) which provided RRs adjusted for age and BMI (Figure), and 8 additional studies which did not adjust for these confounders (N participants = 150,205). The pooled RR for the association of diabetes with VTE in the 10 studies was 1.18 (95% CI, 1.03-1.34). The test for heterogeneity was not significant (I 2 = 23.8%, p = 0.22). Amongst the 10 studies, smaller studies tended to have lower RR estimates: Both the Begg and Egger tests were significant (p = 0.02 and 0.01, respectively). The other 8 studies showed evidence of significant between-study heterogeneity (I 2 = 75.5%, p <0.0001), making a pooled estimate inappropriate. Conclusions: Diabetes is associated with an 18% increased risk of VTE in observational studies after accounting for age and obesity. Possible explanations for the association of diabetes with VTE include increased hypercoagulability or vascular damage caused by the metabolic derangements of diabetes or increased exposure to VTE risk factors in individuals with diabetes. Further research is needed to elucidate the mechanisms of this association and whether improved control of diabetes is associated with reduced VTE risk.

scholarly journals Epidemiology of Venous Thromboembolism in SARS- CoV-2 Infected Patients: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Souvik Maitra ◽  
Dalim Kumar Baidya ◽  
Sulagna Bhattacharjee ◽  
Rahul Kumar Anand ◽  
Bikash Ranjan Ray
Keyword(s):  
Systematic Review ◽  
Venous Thromboembolism ◽  
Observational Studies ◽  
Primary Outcome ◽  
Meta Analysis ◽  
Random Effect ◽  
Thromboembolic Events ◽  
Analysis Model ◽  
Likelihood Estimator ◽  
True Incidence

Early reports from China and Europe indicated that incidence of venous thromboembolism in COVID-19 patients may be high. In this meta-analysis of observational studies was designed to know worldwide prevalence of thromboembolic events in COVID-19 patients. Primary outcome of our review was to assess the proportion of patients with VTE. Secondary outcomes were to assess the proportion of patients with DVT and proportion of patients with PE. Random effect meta-analysis model with restricted maximum likelihood estimator was used for all analysis. Pooled proportion with 95% confidence interval (95% CI) and heterogeneity (I2) was reported for all outcomes. Data of 5426 patients from n=19 articles were included in this systematic review and meta-analysis. Incidence of VTE (95% CI), PE (95% CI) and DVT (95% CI) was 23 (10- 36) %, 12 (6- 17) % and 15 (8- 23) %. We have found a high but incidence of thromboembolic events in COVID-19 patients. Further well-designed studies are required in this area to identify true incidence and risk factors of it.

The association between dietary inflammatory index and risk of central obesity in adults: An updated systematic review and meta-analysis

2020 ◽  
Vol 90 (5-6) ◽  
pp. 535-552 ◽  
Author(s):  
Mahdieh Abbasalizad Farhangi ◽  
Mahdi Vajdi
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Central Obesity ◽  
Assessment Tool ◽  
Weighted Mean Difference ◽  
Meta Analysis ◽  
Dietary Factors ◽  
Cross Sectional ◽  
Inflammatory Status ◽  
Obesity Indices

Abstract. Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn’t evaluate the association between central obesity and dietary inflammation index (DII®) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between DII® with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII® and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included; thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII® scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785–2.841; p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95–1.43; p = 0.154) in the highest DII category was also observed. In subgroup analysis, the continent, dietary assessment tool and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII® scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII® and central obesity indices.

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