Nowadays Coronavirus Disease 2019 (Covid-19) is increasing mortality all over the
world mercilessly. We are learning almost every day about its new symptoms and that it mutates
quickly. This disease has tied us up and made us desperate. The death rate from this disease has
increased in patients who had pre-existing medical conditions, especially cardiovascular ones, by
eliminating the angiotensin-converting enzyme (ACE)-2 receptor in the lungs. Also, ACE1 and
angiotensin receptor blockers (ARB) may stimulate ACE2 expression and worse the prognosis.
Intravenous infusions of ACEIs and ARBs in experimental animals increase the number of ACE2
receptors. Therefore, it may be one of the reasons that COVID-19 infects the cells of patients
treating hypertension. However, most of the congress of cardiology do not recommend to
discontinue these anti-hypertensive drugs. Therefore, this brief report evaluates Covid-19 in the
view of cardiovascular diseases taking into account current reports and suggests some possible
solutions to keep the virus under control.
The Comparative Efficacy and Safety of the Angiotensin Receptor Blockers in the Management of Hypertension and Other Cardiovascular Diseases