Efficacy and Safety of Oral Paracetamol vs. Oral Ibuprofen in the Treatment of Symptomatic Patent Ductus Arteriosus in Premature Infants

2019 ◽  
Vol 21 (2) ◽  
pp. 113-121
Author(s):  
Birol Karabulut ◽  
Sebnem Paytoncu
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Efficacy And Safety ◽  
Oral Ibuprofen ◽  
Patent Ductus

scholarly journals Repeated Courses of Oral Ibuprofen in Premature Infants with Patent Ductus Arteriosus: Efficacy and Safety

2017 ◽  
Vol 58 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Haşim Olgun ◽  
Naci Ceviz ◽  
İbrahim Kartal ◽  
İbrahim Caner ◽  
Mehmet Karacan ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Efficacy And Safety ◽  
Oral Ibuprofen ◽  
Patent Ductus

scholarly journals Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus

2017 ◽  
Vol 46 (2) ◽  
pp. 811-818 ◽  
Author(s):  
Manar Al-lawama ◽  
Iyad Alammori ◽  
Tariq Abdelghani ◽  
Eman Badran
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Primary Closure ◽  
Ductus Arteriosus ◽  
Randomized Study ◽  
Inclusion Criteria ◽  
Short Term ◽  
Significant Difference ◽  
Oral Ibuprofen ◽  
Patent Ductus

Objective This study was performed to investigate the safety and efficacy of oral paracetamol versus oral ibuprofen in the treatment of patent ductus arteriosus (PDA) in premature infants. Methods Premature infants with PDA with a gestational age of ≤32 weeks or birth weight of ≤1500 g were included in this randomized study. Results A total of 120 premature infants fulfilled the inclusion criteria. Of these 120 infants, 34 fulfilled the treatment criteria and 22 were finally randomized. We found no significant difference in the mortality or primary closure rates between the two groups. We also found no significant difference in the short-term neonatal outcomes. Conclusions Either oral paracetamol or oral ibuprofen can be used safely and effectively to treat PDA in premature infants.

scholarly journals Effects of prophylactic oral ibuprofen on the closure rate of patent ductus arteriosus in premature infants

Medicine ◽  
2018 ◽  
Vol 97 (37) ◽  
pp. e12206 ◽  
Author(s):  
Yanjie Ding ◽  
Xuan Wang ◽  
Yanqiu Wu ◽  
Hui Li ◽  
Jiaju Xu ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Premature Infants ◽  
Ductus Arteriosus ◽  
Closure Rate ◽  
Oral Ibuprofen ◽  
Patent Ductus
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