Senna-alexandrina abuse

2021 ◽  
Vol 1853 (1) ◽  
pp. 429-429
Keyword(s):  
2020 ◽  
Vol 11 (7) ◽  
pp. 652-671
Author(s):  
Luciano Mamede de Freitas Junior ◽  
Eduardo Bezerra de Almeida Junior ◽  
Silvio Gomes Monteiro

A busca por novos medicamentos à base de plantas para tratamento de doenças tem aumentado, sendo que 3/4 da população mundial utilizam remédios tradicionais tornando importante a realização de estudos sobre as alternativas terapêuticas através de abordagens etnobotânicas e quimiotaxonômicas. Foram obtidos dados e informações de 54 informantes, vendedores de plantas para uso medicinal, entrevistados individualmente nas feiras e mercados de São Luis, Maranhão, Brasil. Os dados foram analisados utilizando a frequência relativa (RF) e o fator de consenso informativo (ICF), e 30,3% das espécies selecionadas tiveram amostras coletadas e identificadas no Herbário do MAR, pertencendo a 20 famílias botânicas, sendo que 11,1% pertencem à família Asteraceae e 11,1% à família Fabaceae. As espécies mais citadas pelos informantes foram Hibiscus sabdariffa L., Baccharis crispa Spreng., Senna alexandrina Mill., Camellia sinensis (L.) Kuntze, Quassia amara L., Annona muricata L., Equisetum arvense L., com valores de RF > 5 e ICF > 0,50. A parte vegetal mais utilizada nos fitoterápicos para o tratamento da obesidade é a folha (74,1%), tendo a infusão (92,6%) como modo de preparo mais recomendado. Nossos resultados revelam uma lista de espécies indicadas pelos informantes para o tratamento da obesidade, algumas com estudos biológicos existentes, outras ausentes de estudos pré-clínicos e clínicos. As abordagens são importantes para a validação destas plantas através de estudos experimentais, considerando a necessidade de tais estudos para garantia da função biológica, eficácia e segurança das alternativas terapêuticas propostas.  


Separations ◽  
2020 ◽  
Vol 7 (4) ◽  
pp. 65
Author(s):  
Mashail N. AlZain ◽  
Abdulrahman A. AlAtar ◽  
Abdulaziz A. Alqarawi ◽  
Ramzi A. Mothana ◽  
Omar M. Noman ◽  
...  

Symbiotic arbuscular mycorrhizal fungi (AMF) play a major role in plant development, growth, and relationships with the environment through a change in the accumulation of secondary metabolites; hence, we planned to investigate AMF’s influence on sennoside A and B accumulation in Senna alexandrina (SA) and Senna italica (SI). Seeds of SA (S. alexandrina free of mycorrhizae) and SI (S. italica free of mycorrhizae) were planted in two types of soils: +mycorrhiza and—mycorrhiza. The plant leaves of SA, SI, S. alexandrina with mycorrhizae (SAM) and S. italica with mycorrhizae (SIM) were collected and extracted (with 85% methanol), and sennoside A and B content was evaluated by the HPLC–UV method. The antioxidant activity of SA, SI, SAM and SIM was evaluated by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods, while antimicrobial properties were evaluated by the minimum inhibitory concentration method (MIC). The AMF colonization was 85.66% and 85%, respectively, in the roots of SA and SI. The HPLC analysis showed a significant increase in (%) the content of sennoside A/sennoside B by 71.11/88.21, respectively, in SAM and 6.76/36.37 in SIM, which clearly indicated positive AMF effects. The DPPH/ABTS [The half maximal inhibitory concentration (IC50): 235.9/321.5 µg/mL] scavenging activity of SAM was comparatively higher and it also exhibited strong antibacterial action (MIC: 156.25 µg/mL), which supported the increase in sennoside content. This finding may be useful for further investigations of the symbiotic relation of mycorrhizal fungi with other plant species.


2016 ◽  
Vol 41 (1) ◽  
pp. 147-154 ◽  
Author(s):  
S. Kundu ◽  
S. Roy ◽  
S. Nandi ◽  
B. Ukil ◽  
Larisha Mawkhlieng Lyndem

Author(s):  
Mozdelfa Adam Babiker Ali, Haidar Abd Algadir Mohamed Ahmed

Ethnobotany is the scientific study of the relationships that exist between people and plants. Ethnobotanists aim to document, describe and explain complex relationships between cultures and plants, focusing primarily on how plants are used, managed and perceived across human societies. This includes use for food, clothing, currency, ritual, medicine, dye, construction, cosmetics. Ethnobotanical studies are often significant in revealing locally important plant species especially for the discovery of crude drugs The documentation of traditional knowledge, especially on the medicinal uses of plants. has provided many important drugs of modern day. Out of the total flowering plants reported from the world, more than 50, 000 are used for medicinal purposes ( Govaerts, 2001 ). Extensive and intensive field trips were conducted to the study area during a course of two years from 2013 to 2015 representing several sites through Jebel Aulia district, Khartoum state. The study revealed a total of 117 species belonging to 100 genera and 45 families were recorded at Jebel Aulia locality. The family Poaceae was found to be the richest (13 species) followed by Ceasalpiniaceae, Euphorbiaceae, Mimosaceae (7 species) and Asteraceae (6 species). Herbs have dominated the vegetation of the study area (62. 40%) followed with trees (15. 40%), shrubs (8. 5%). Genus Euphorbia was considered as the most speciose (4 species) pursued with Senna and Ipomea which were represented by 3 species each. Tribulus longipetalus and Cyperus alopecuroides along with their Ethnomedicinal uses were documented for the first time. Fruits were the most commonly used plant part to prepare medicine followed with leaves and seeds. The main preparation methods of herbal remedies were infusion (25%) followed with decoction (14. 3%), edible (10. 7%) and pills (10. 7%). Oral administration was the most common route of herbal remedies within traditional medicine. Urinary tracts, kidney and abdominal complaints were the most frequent ailments traditionally healed. The source of medicinal plants was wild, (41. 66%), were cultivated (33. 34%) and (25%) were commercially bought from the market. Senna alexandrina was the most cited and important plant in the study area followed with Ziziphus spina-christi, Acacia nilotica, Solenostemma argel and Cymbopogon proximus. High informants consensus factor was indicated for Medicinal, furniture and food uses. Ziziphus spina Christi, Acacia senegal, Allium sativum and Cinnamomum verum have highest use-value ranging from (0. 062 to 0. 05). Cytotoxicity was evaluated using plants with a high relative frequency of citation. The results revealed that LC50 of water and ethanolic extracts of Acacia nilotica were more than 1000 µg/ml which considered not toxic and consequently safe at this dose. Whereas, water and ethanolic extracts of Senna alexandrina were less than LC 50 =256. 206 - 409. 6079 µg/ml. which is considered moderately toxic. Therefore, Senna extracts should be carefully used.


2020 ◽  
Vol 1798 (1) ◽  
pp. 242-242
Keyword(s):  

2014 ◽  
Vol 29 (2) ◽  
pp. 180-184 ◽  
Author(s):  
Francesco Epifano ◽  
Serena Fiorito ◽  
Marcello Locatelli ◽  
Vito Alessandro Taddeo ◽  
Salvatore Genovese

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