Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study

2020 ◽  
Author(s):  
Jia Liu ◽  
Wei Yang ◽  
Hongyu Luo ◽  
Yixin Ma ◽  
Huan Zhao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly Patients ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Controlled Study ◽  
Val66met Polymorphism

scholarly journals Elevated Peripheral Brain-Derived Neurotrophic Factor Level Associated With Decreasing Insulin Secretion May Forecast Memory Dysfunction in Patients With Long-Term Type 2 Diabetes

2022 ◽  
Vol 12 ◽  
Author(s):  
Xi Huang ◽  
Zuolin Xie ◽  
Chenchen Wang ◽  
Shaohua Wang
Keyword(s):  
Type 2 Diabetes ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Islet Function ◽  
Bdnf Level ◽  
C Peptide ◽  
Val66met Polymorphism ◽  
Logical Memory

BackgroundWith the progressive course of diabetes and the decline in islet function, the cognitive dysfunction of patients aggravated.ObjectiveWe aimed to investigate the roles of brain-derived neurotrophic factor (BDNF) and the Val66Met polymorphism in mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM).MethodsA total of 169 Chinese patients with T2DM were involved and divided into long-term (diabetes duration >10 years) and short-term (diabetes duration ≤10 years) diabetes, and in each group, the patients were separated as MCI and the control. Demographic characteristics, clinical variables, and cognitive performances were assessed. The plasma BDNF level was measured via enzyme-linked immunosorbent assay. The Val66Met polymorphisms were analyzed.ResultsLong-term T2DM have lower 2 h postprandial C-peptide (p < 0.05). The BDNF level was slightly higher in patients with MCI than in the controls in each duration group without statistical significance. The relationship of BDNF to Montreal Cognitive Assessment was not proven either. However, in the long-term diabetes group, BDNF concentration remained as an independent factor of logical memory test (β = −0.27; p < 0.05), and they were negatively correlated (r = −0.267; p = 0.022); BDNF was also negatively correlated with fasting C-peptide (r = −0.260; p = 0.022), 2 h postprandial C-peptide (r = −0.251; p = 0.028), and homeostasis model assessment of insulin resistance (r = −0.312; p = 0.006). In genotypic groups, BDNF Val/Val performed better in logical memory test than Met/Met and Val/Met.ConclusionElevated peripheral BDNF level associated with declined islet function, when combined with its Val66Met polymorphism, may forecast memory dysfunction in patients with long-term T2DM.

Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment

2010 ◽  
Vol 11 (6) ◽  
pp. 774-780 ◽  
Author(s):  
Orestes Vicente Forlenza ◽  
Breno Satler Diniz ◽  
Antonio Lucio Teixeira ◽  
Elida Benquique Ojopi ◽  
Leda Leme Talib ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Neurotrophic Factor ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism

scholarly journals Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes

2016 ◽  
Vol 7 (20) ◽  
pp. 615 ◽  
Author(s):  
Blanca Murillo Ortíz ◽  
Joel Ramírez Emiliano ◽  
Edna Ramos-Rodríguez ◽  
Sandra Martínez-Garza ◽  
Hilda Macías-Cervantes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Neurotrophic Factor ◽  
Plasma Levels ◽  
Brain Derived Neurotrophic Factor

Association of Plasma DPP4 Activity With Mild Cognitive Impairment in Elderly Patients With Type 2 Diabetes: Results From the GDMD Study in China

Diabetes Care ◽  
2016 ◽  
Vol 39 (9) ◽  
pp. 1594-1601 ◽  
Author(s):  
Tianpeng Zheng ◽  
Linyuan Qin ◽  
Bo Chen ◽  
Xueping Hu ◽  
Xiaoxi Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Elderly Patients
Sign in / Sign up

Export Citation Format

Share Document