Erratum to: A best practice position statement on pregnancy in chronic kidney disease: the Italian Study Group on Kidney and Pregnancy

Organ damages, which contribute to the overall cardiovascular risk of hypertensive patients, should be early detected, prevented and treated. The study evaluated organ damage in a hypertensive study group with chronic kidney disease (CKD), compared with a study group of hypertension without CKD. Albuminuria was present in 41.2% and reduced estimated glomerular filtration rate [60 ml/min/m2 was present in 72.5% of hypertensive with CKD. The comparison of organ damage revealed in the CKD group a statistical significant higher prevalence of organ damage as follows: intima-media thickness ]0.9 mm in 39.9% vs 10.5%, carotid plaques in 28.2% vs 12.6%, left ventricular hypertrophy in 39.9% vs 31%, ankle brachial index in 6.2% vs 3.5%. Early detection and treatment of additional cardiovascular risk factors as dyslipidaemia and hyperglycaemia, that have significant role in the pathogenesis of organ damage, contribute to the better prevention of cardiovascular and renal complications in hypertension with CKD.

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Chronic kidney disease and measurement of albuminuria or proteinuria: a position statement

The Medical Journal of Australia ◽

10.5694/mja11.11468 ◽

2012 ◽

Vol 197 (4) ◽

pp. 224-225 ◽

Cited By ~ 82

Author(s):

David W Johnson ◽

Graham R D Jones ◽

Timothy H Mathew ◽

Marie J Ludlow ◽

Stephen J Chadban ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Position Statement

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Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higher (eGFR<45 mL/min/1.73 m2): a summary document from the European Renal Best Practice Group

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfw411 ◽

2017 ◽

Vol 32 (1) ◽

pp. 9-16 ◽

Cited By ~ 32

Author(s):

Ken Farrington ◽

Adrian Covic ◽

Ionut Nistor ◽

Filippo Aucella ◽

Naomi Clyne ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Clinical Practice ◽

Kidney Disease ◽

Clinical Practice Guideline ◽

Practice Guideline ◽

Older Patients ◽

Best Practice ◽

Chronic Kidney Disease Stage ◽

Disease Stage ◽

Practice Group

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Chronic kidney disease as a global public health problem: Approaches and initiatives – a position statement from Kidney Disease Improving Global Outcomes

Kidney International ◽

10.1038/sj.ki.5002343 ◽

2007 ◽

Vol 72 (3) ◽

pp. 247-259 ◽

Cited By ~ 755

Author(s):

A.S. Levey ◽

R. Atkins ◽

J. Coresh ◽

E.P. Cohen ◽

A.J. Collins ◽

...

Keyword(s):

Public Health ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Health Problem ◽

Public Health Problem ◽

Position Statement ◽

Global Public Health ◽

Global Public Health Problem

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Is Transferrin Saturation a Useful Marker of Iron Metabolism in Patients with Chronic Kidney Disease Treated with Hemodialysis?

The Open Urology & Nephrology Journal ◽

10.2174/1874303x01912010077 ◽

2019 ◽

Vol 12 (1) ◽

pp. 77-82

Author(s):

Ewa Kwiatkowska ◽

Martyna Opara ◽

Sebastian Kwiatkowski ◽

Leszek Domański ◽

Małgorzata Marchelek-Myśliwiec ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Kidney Disease ◽

Iron Metabolism ◽

Complete Blood Count ◽

Transferrin Saturation ◽

Maintenance Hemodialysis ◽

Study Group ◽

Ferritin Concentration ◽

Lower Limit Of Normal

Background: According to the currently applicable KDIGO-2012 and ERBP 2013 guidelines, iron metabolism assessments for patients with Chronic Kidney Disease (CKD) are performed using such parameters as ferritin concentration and Transferrin Saturation (TSAT). Their values are to be treated as a basis on which to decide on providing iron substitution. Patients with Stage 5 CKD on maintenance hemodialysis commonly suffer from malnutrition syndrome and inflammation. One of the markers for malnutrition and inflammation is low transferrin concentration. Our study focused on establishing what percentage of patients this applied to and whether or not the transferrin saturation figure was artificially inflated in such cases. Materials and Methods: The study group included 66 patients with Stage 5 CKD on maintenance hemodialysis. Such data were analyzed as complete blood count, iron and ferritin concentrations, and Transferrin Saturation (TSAT). Other parameters - age, sex, time from their first hemodialysis, and the quality of their dialysis in the last six months – the Kt/V average. Results: It was found that only 12% of the study group patients had their transferrin concentrations above the lower limit of normal. The TSAT value correlated negatively with transferrin concentration. Transferrin concentration correlated negatively with time from first hemodialysis or ferritin concentration, and positively with body weight. Normal transferrin concentration was only seen in patients with ferritin concentrations of up to 400 μg/L. The group was divided according to transferrin concentration of <1.5 g/L or >1.5 g/L. These groups differed significantly in ferritin concentration and transferrin saturation. (p = 0.0005 and p = 0.004, respectively). The 1.5 g/L transferrin concentration point divides patients with mild and medium malnutrition. It is also the minimum transferrin content necessary to achieve hemoglobin values ≥10 g/dL determined using the ROC curve. Conclusion: Low transferrin concentrations cause abnormally high TSAT values. In most patients on maintenance hemodialysis, this marker is not useful for assessing the availability of iron for erythropoiesis.

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