Bidirectional relationship between depressive symptoms and physical performance in community-dwelling older people with subjective memory complaints

ObjectiveTo assess whether apathy and depressive symptoms are independently associated with incident dementia during 6-year follow-up in a prospective observational population-based cohort study.MethodsParticipants were community-dwelling older people in the Prevention of Dementia by Intensive Vascular Care trial, aged 70–78 years, without dementia at baseline. Apathy and depressive symptoms were measured using the 15-item Geriatric Depression Scale (GDS-15). Dementia during follow-up was established by clinical diagnosis confirmed by an independent outcome adjudication committee. Hazard ratios (HRs) were calculated using Cox regression analyses. Given its potentially strong relation with incipient dementia, the GDS item referring to memory complaints was assessed separately.ResultsDementia occurred in 232/3,427 (6.8%) participants. Apathy symptoms were associated with dementia (HR 1.28, 95% confidence interval [CI] 1.12–1.45; p < 0.001), also after adjustment for age, sex, Mini-Mental State Examination score, disability, and history of stroke or cardiovascular disease (HR 1.21, 95% CI 1.06–1.40; p = 0.007), and in participants without depressive symptoms (HR 1.26, 95% CI 1.06–1.49; p = 0.01). Depressive symptoms were associated with dementia (HR 1.12, 95% CI 1.05–1.19), also without apathy symptoms (HR 1.16, 95% CI 1.03–1.31; p = 0.015), but not after full adjustment or after removing the GDS item on memory complaints.ConclusionsApathy and depressive symptoms are independently associated with incident dementia in community-dwelling older people. Subjective memory complaints may play an important role in the association between depressive symptoms and dementia. Our findings suggest apathy symptoms may be prodromal to dementia and might be used in general practice to identify individuals without cognitive impairment at increased risk of dementia.

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Do opposite ends of same factors underlie life satisfaction vs. depressive symptoms among older people?

Aging Clinical and Experimental Research ◽

10.1007/s40520-020-01765-z ◽

2021 ◽

Author(s):

Katja Pynnönen ◽

Katja Kokko ◽

Milla Saajanaho ◽

Timo Törmäkangas ◽

Erja Portegijs ◽

...

Keyword(s):

Life Satisfaction ◽

Depressive Symptoms ◽

Older People ◽

Executive Functions ◽

Physical Performance ◽

Well Being ◽

Community Dwelling ◽

Satisfaction With Life Scale ◽

Financial Situation ◽

Self Acceptance

Abstract Background Although depressive symptoms are more common among older than younger age groups, life satisfaction tends to remain stable over the life course, possibly because the underlying factors or processes differ. Aim To study whether the factors that increase the likelihood of high life satisfaction also decrease the likelihood of depressive symptoms among older people. Methods The data were a population-based probability sample drawn from community-dwelling people aged 75, 80, and 85 years (n = 1021). Participants’ life satisfaction was measured with the Satisfaction with Life Scale and depressive symptoms with the Centre for Epidemiologic Studies Depression Scale (CES-D). Physical performance, perceived financial situation, executive functions, loneliness, self-acceptance, and having interests in one’s life were studied as explanatory variables. The data were analyzed using cross-sectional bivariate linear modeling. Results Better physical performance, not perceiving loneliness, having special interests in one’s life, and higher self-acceptance were associated with higher life satisfaction and fewer depressive symptoms. Better financial situation was related only to life satisfaction. Executive functions were not associated with either of the outcomes. Discussion The opposite ends of the same factors underlie positive and negative dimensions of mental well-being. Conclusion Further studies are warranted to better understand how people maintain life satisfaction with aging when many resources may diminish and depressive symptoms become more prevalent.

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Relationship between subjective memory complaints and objective memory impairment in a community-dwelling elderly population

Journal of Clinical Psychiatry ◽

10.5505/kpd.2018.95967 ◽

2018 ◽

Vol 21 (4) ◽

pp. 334-340

Author(s):

Elif Onur Aysevener ◽

Neşe Direk ◽

Ebru Onat Özsoydan ◽

Meliha Diriöz

Keyword(s):

Memory Impairment ◽

Elderly Population ◽

Community Dwelling ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints

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Symptoms of Depression in a Large Healthy Population Cohort are related to Subjective Memory Complaints and Memory Performance in Negative Contexts

10.1101/101642 ◽

2017 ◽

Cited By ~ 1

Author(s):

Susanne Schweizer ◽

Rogier A. Kievit ◽

Tina Emery ◽

Richard N. Henson ◽

Keyword(s):

Depressive Symptoms ◽

General Population ◽

Memory Performance ◽

Large Population ◽

Healthy Population ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Symptoms Of Depression ◽

Memory Complaints ◽

The Impact

AbstractDecades of research have investigated the impact of clinical depression on memory, which has revealed biases and in some cases impairments. However, little is understood about the effects of sub-clinical symptoms of depression on memory performance in the general population. Here we report the effects of symptoms of depression on memory problems in a large population-derived cohort (N = 2544), 87% of whom reported at least one symptom of depression. Specifically, we investigate the impact of depressive symptoms on subjective memory complaints, objective memory performance on a standard neuropsychological task and, in a subsample (n = 288), objective memory in affective contexts. There was a dissociation between subjective and objective memory performance, with depressive symptoms showing a robust relationship with self-reports of memory complaints, even after adjusting for age, gender, general cognitive ability and symptoms of anxiety, but not with performance on the standardised measure of verbal memory. Contrary to our expectations, hippocampal volume (assessed in a subsample, n = 592) did not account for significant variance in subjective memory, objective memory or depressive symptoms. Nonetheless, depressive symptoms were related to poorer memory for pictures presented in negative contexts, even after adjusting for memory for pictures in neutral contexts. Thus the symptoms of depression, associated with subjective memory complaints, appear better assessed by memory performance in affective contexts, rather than standardised memory measures. We discuss the implications of these findings for understanding the impact of depressive symptoms on memory functioning in the general population.

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The impact of subjective memory complaints on quality of life in community-dwelling older adults

Psychogeriatrics ◽

10.1111/psyg.12056 ◽

2014 ◽

Vol 14 (3) ◽

pp. 175-181 ◽

Cited By ~ 24

Author(s):

Yohko Maki ◽

Tomoharu Yamaguchi ◽

Tetsuya Yamagami ◽

Tatsuhiko Murai ◽

Kenji Hachisuka ◽

...

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Community Dwelling ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

The Impact ◽

Community Dwelling Older Adults

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Association between childhood socioeconomic status and subjective memory complaints among older adults: results from the Japan Gerontological Evaluation Study 2010

International Psychogeriatrics ◽

10.1017/s1041610219000814 ◽

2019 ◽

Vol 31 (12) ◽

pp. 1699-1707 ◽

Cited By ~ 3

Author(s):

Toshinori Nishizawa ◽

Ayako Morita ◽

Takeo Fujiwara ◽

Katsunori Kondo

Keyword(s):

Older Adults ◽

Socioeconomic Status ◽

Evaluation Study ◽

Community Dwelling ◽

Self Report ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

Childhood Socioeconomic Status ◽

Community Dwelling Older Adults

ABSTRACTBackground:Subjective memory complaints (SMC) have been suggested as an early marker of mild cognitive impairment and dementia. However, there is a paucity of evidence on the effects of early life conditions on the development of SMC in old age. This study is aimed at investigating the association between childhood socioeconomic status (SES) and SMC in community-dwelling older adults.Methods:We used the data of the Japan Gerontological Evaluation Study, a population-based cohort study of people aged 65 years or older enrolled from 28 municipalities across Japan. Childhood SES and SMC in everyday life were assessed from the self-report questionnaire administered in 2010 (n = 16,184). Poisson regression was performed to determine their association, adjusted for potential confounders and life-course mediators and examined cohort effects.Results:We identified SMC in 47.4% of the participants. After adjusting for sex, age, and number of siblings, low and middle childhood SES were associated with 29% (prevalence ratio [PR]: 1.29, 95% confidence interval [CI]: 1.22, 1.36) and 10% higher prevalence of SMC (PR: 1.10, 95%CI: 1.04, 1.17), respectively, compared with high childhood SES (p for trend <.001). The interaction terms between childhood SES and age groups were not statistically significant.Conclusion:Childhood SES is significantly associated with SMC among community-dwelling older adults. Efforts to minimize childhood poverty may diminish or delay the onset of SMC and dementia in later life.

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