Antiallodynic Effect of Piperine in Neuropathic Rats

2020 ◽  
Vol 30 (4) ◽  
pp. 482-487
Author(s):  
Luis Arturo Sánchez-Trujillo ◽  
Jorge Luis Mendoza-Monroy ◽  
Héctor Isaac Rocha-González ◽  
Geovanna Nallely Quiñonez-Bastidas ◽  
Jose Luis Balderas-López ◽  
...  
Keyword(s):  
Antiallodynic Effect

P.l.c.042 Antihyperalgesic and antiallodynic effect of chronic lactoferrin administration in neuropathic pain

2009 ◽  
Vol 19 ◽  
pp. S275-S276
Author(s):  
A. Onal ◽  
G. Kayalioglu ◽  
A. Parlar ◽  
A. Keser ◽  
S. Ulker
Keyword(s):  
Neuropathic Pain ◽  
Antiallodynic Effect

scholarly journals Investigation of the Combination of Pregabalin with Duloxetine or Amitriptyline on the Pharmacokinetics and Antiallodynic Effect During Neuropathic Pain in Rats

2021 ◽  
pp. E511-E520
Keyword(s):  
Neuropathic Pain ◽  
Motor Coordination ◽  
Combined Therapy ◽  
Pharmacokinetic Analysis ◽  
Test Results ◽  
Rotarod Test ◽  
Model Study ◽  
Liquid Chromatography Tandem Mass ◽  
Male Wistar Rats ◽  
Antiallodynic Effect

BACKGROUND: Amitriptyline, duloxetine, and pregabalin are among the most pharmacotherapeutic, effective treatments for neuropathic pain control. However, the evaluation of synergism by combining these treatments is still poorly investigated. OBJECTIVES: To evaluate the pharmacokinetics of the combination of pregabalin plus duloxetine and pregabalin plus amitriptyline, as well as the effect of these on neuropathic pain on rodent model. STUDY DESIGN: The experimental study. SETTING: The research took place in the research laboratories at the Federal University of Alfenas after ethics committee approval. METHODS: This study used male Wistar rats weighing between 220 and 250 g. The animals were randomly divided into the following groups: monotherapy (pregabalin, amitriptyline, duloxetine), combined therapy (pregabalin + amitriptyline, pregabalin + duloxetine), and vehicle (ultrapure water). Pharmacokinetic analysis of pregabalin or combination (pregabalin + amitriptyline or pregabalin + duloxetine) in the plasma were performed by ultraperformance liquid chromatography tandem mass spectrometry. Neuropathic pain was induced by sciatic nerve constriction (chronic constriction injury [CCI]) model, and nociceptive threshold was measured by von Frey filaments test. In addition, to evaluate the influence of the treatments on the motor coordination, the rotarod test was used. RESULTS: The pharmacokinetic disposition of pregabalin was changed in the association with amitriptyline, presenting a clearance reduction and consequently an increase in bioavailability. Furthermore, after the 14th day of CCI, pregabalin was administered orally and induced antiallodynic effect after 1, 2:15, 4, and 8 hours of its administration and showed the greatest antiallodynic effect after 4 hours of its administration. Moreover, this effect was prolonged (up to 8 hours) by combination with amitriptyline. Additionally, pregabalin and pregabalin + duloxetine showed a hypoalgesic effect in sham rats. In addition, the rotarod test results showed that drugs did not influence the motor coordination of the rats. LIMITATIONS: Potential competition mechanisms during the excretion of pregabalin, when pregabalin was combined with amitriptyline, were not investigated in this study. CONCLUSIONS: The data demonstrated that combined therapy of pregabalin plus amitriptyline improved the bioavailability of pregabalin and potentiated the efficacy of the antiallodynic effect of pregabalin alone, proving to be advantageous for the treatment of sciatic neuropathic pain. KEY WORDS: Neuropathic pain, pregabalin, duloxetine, amitriptyline, pharmacokinetic, antiallodynic effect, combined therapy, rats

scholarly journals Antiallodynic effect and side effects of Phα1β, a neurotoxin from the spider Phoneutria nigriventer: Comparison with ω-conotoxin MVIIA and morphine

Toxicon ◽  
2011 ◽  
Vol 58 (8) ◽  
pp. 626-633 ◽  
Author(s):  
A.H. de Souza ◽  
M.C. Lima ◽  
C.C. Drewes ◽  
J.F. da Silva ◽  
K.C.L. Torres ◽  
...  
Keyword(s):  
Side Effects ◽  
Antiallodynic Effect ◽  
Phoneutria Nigriventer

Antihyperalgesic and antiallodynic effect of sirolimus in rat model of adjuvant arthritis

2013 ◽  
Vol 705 (1-3) ◽  
pp. 35-41 ◽  
Author(s):  
Cahide Elif Orhan ◽  
Aytül Önal ◽  
Yiğit Uyanıkgil ◽  
Sibel Ülker
Keyword(s):  
Rat Model ◽  
Adjuvant Arthritis ◽  
Antiallodynic Effect

Antiallodynic Effect of Intrathecal Korean Red Ginseng in Cisplatin-Induced Neuropathic Pain Rats

Pharmacology ◽  
2019 ◽  
Vol 105 (3-4) ◽  
pp. 173-180 ◽  
Author(s):  
Yeo Ok Kim ◽  
Ji A Song ◽  
Woong Mo Kim ◽  
Myung Ha Yoon
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Receptor Antagonist ◽  
Mrna Expression ◽  
Therapeutic Potential ◽  
Red Ginseng ◽  
Sprague Dawley ◽  
Korean Red Ginseng ◽  
Receptor Mrna ◽  
Antiallodynic Effect

Background: Chemotherapy-induced neuropathic pain (CINP) is a serious side effect of chemotherapy. Korean Red Ginseng (KRG) is a popular herbal medicine in Asian countries. We examined the therapeutic potential of intrathecally administered KRG for CINP and clarified the mechanisms of action with regard to 5-hydroxytryptamine (5-HT)7 receptor at the spinal level. Methods: CINP was evoked by intraperitoneal injection of cisplatin in male Sprague-Dawley rats. After examining the effects of intrathecally administered KRG on CINP, 5-HT receptor antagonist (dihydroergocristine [DHE]) was pretreated to determine the involvement of 5-HT receptor. In addition, intrathecal 5-HT7 receptor antagonist (SB269970) was administered to define the role of 5-HT7 receptor on the effect of KRG. 5-HT7 receptor mRNA expression levels and 5-HT concentrations were examined in the spinal cord. Results: Intrathecally administered KRG produced a limited, but a dose-dependent, antiallodynic effect. Intrathecally administered DHE antagonized the antiallodynia caused by KRG. Furthermore, intrathecal SB269970 also reversed the effect of KRG. No changes in 5-HT7 receptor mRNA expression were seen in the dorsal horn of the spinal cord after cisplatin injection. After injecting cisplatin, 5-HT levels were decreased in the spinal cord, whereas those of 5-HT were increased by intrathecal KRG. Conclusions: Intrathecally administered KRG decreased CINP. In addition, spinal 5-HT7 receptors contributed to the antiallodynic effect of KRG.

Combined antiallodynic effect of Neurotropin® and pregabalin in rats with L5-spinal nerve ligation

Life Sciences ◽  
2013 ◽  
Vol 92 (4-5) ◽  
pp. 259-265 ◽  
Author(s):  
Ryohei Okazaki ◽  
Hiroyoshi Namba ◽  
Hiroyuki Yoshida ◽  
Hisashi Okai ◽  
Kazuki Taguchi ◽  
...  
Keyword(s):  
Spinal Nerve ◽  
Spinal Nerve Ligation ◽  
Antiallodynic Effect

Ultra-Low Doses of Naltrexone Enhance the Antiallodynic Effect of Pregabalin or Gabapentin in Neuropathic Rats

2017 ◽  
Vol 78 (8) ◽  
pp. 371-380 ◽  
Author(s):  
Jorge B. Pineda-Farias ◽  
Nadia L. Caram-Salas ◽  
Ana B. Salinas-Abarca ◽  
Jorge Ocampo ◽  
Vinicio Granados-Soto
Keyword(s):  
Low Doses ◽  
Antiallodynic Effect

Adenosine Triphosphate–Sensitive Potassium Channel Blockers Attenuate the Antiallodynic Effect of R-PIA in Neuropathic Rats

2011 ◽  
Vol 112 (6) ◽  
pp. 1494-1499 ◽  
Author(s):  
Jun-Gol Song ◽  
Kyung Don Hahm ◽  
Young Ki Kim ◽  
Jeong Gil Leem ◽  
Chung Lee ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Adenosine Triphosphate ◽  
Channel Blockers ◽  
Potassium Channel Blockers ◽  
Antiallodynic Effect

scholarly journals Antiallodynic effect of intrathecal epigallocatechin-3-gallate due to suppression of reactive oxygen species

2014 ◽  
Vol 67 (2) ◽  
pp. 123 ◽  
Author(s):  
Sang Soon An ◽  
Yeo Ok Kim ◽  
Cheon Hee Park ◽  
Hai Lin ◽  
Myung Ha Yoon
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Antiallodynic Effect
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