Vasopressin analogues with effect on central nervous system: Synthesis and biological properties

1983 ◽  
Vol 48 (10) ◽  
pp. 2862-2873 ◽  
Author(s):  
František Brtník ◽  
Ivan Krejčí ◽  
Běla Kupková ◽  
Pavel Hrbas ◽  
Jana Škopková ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Amino Acid ◽  
Passive Avoidance ◽  
Biological Properties ◽  
Passive Avoidance Test ◽  
System Synthesis ◽  
Avoidance Test ◽  
Vasopressin Analogues

Synthesis of four vasopressin analogues which do not contain the glycinamine residue in position 9 and have a basic non-coded amino acid in position 8 is described. All the analogues exhibit very low endocrine activities and are effective in the passive avoidance test.

Polarographic study of hydrolysis of [8-lysine]vasopressin and its derivatives with blood serum of pregnant women

1980 ◽  
Vol 45 (4) ◽  
pp. 1099-1108 ◽  
Author(s):  
Mikuláš Chavko ◽  
Michal Bartík ◽  
Evžen Kasafírek
Keyword(s):  
Blood Serum ◽  
Pregnant Women ◽  
Degree Of Hydrolysis ◽  
Polarographic Study ◽  
Ph Optimum ◽  
Lysine Vasopressin ◽  
Rate Of Hydrolysis ◽  
Hydrolysis Of ◽  
Vasopressin Analogues

A polarographic study of the hydrolysis of [8-lysine]vasopressin and some hormonogens of the vasopressin series with the blood serum of women in the last week of pregnancy was studied. The dependence of hydrolysis on pH (pH optimum: 7.4-7.50, substrate concentration (Km 1.2 . 10-5M), pH stability and thermal stability were determined. The rate of hydrolysis of individual vasopressin analogues decreases in the order: [8-lysine]vasopressin > Nα-glycyl-prolyl[8-lysine]-vasopressin > Nα-leucyl-[8-lysine]vasopressin > Nα-alanyl-[8-lysine]vasopressin > Nα-phenyl alanyl-[8-lysine]vasopressin > Nα-diglycyl-[8-lysine]vasopressin > Nα-prolyl-[8-lysine]vasopressin > Nα-triglycyl-[8-lysine]vasopressin > Nα-sarcosyl-glycyl-[8-lysine]vasopressin. The degree of hydrolysis gradually increases to a multiple with the length of the pregnancy in consequence of the presence of oxytocine. However, vasopressin is also hydrolysed to a small extent with the enzymes from the blood sera of non-pregnant women. Under similar analytical conditions oxytocin was not hydrolysed with the sera of non-pregnant women and therefore oxytocin is a more suitable substrate than vasopressin for polarographic determination of serum oxytocinase.

Vasopressin analogues modified in positions 2, 3 and 8. Synthesis and biological effects

1983 ◽  
Vol 48 (5) ◽  
pp. 1341-1351 ◽  
Author(s):  
Ivo Bláha ◽  
Danuta Konopinska ◽  
Milan Zaoral
Keyword(s):  
Amino Acid ◽  
Solid Phase ◽  
Biological Effects ◽  
Solution Synthesis ◽  
Antidiuretic Activity ◽  
Pressor Activity ◽  
Vasopressin Analogues

Four vasopressin analogues, modified in positions 2, 3 and 8 were prepared by solid phase as well as solution synthesis. Analogues, containing a D-amino acid in position 3, exhibit a low but markedly specific antidiuretic activity. Analogues with a D-substituent in position 2 show a more specific pressor activity.

Circular dichroism studies of some arginine-vasopressin analogues

1988 ◽  
Vol 31 (1-2) ◽  
pp. 87-100 ◽  
Author(s):  
Zbigniew Grzonka ◽  
Elwira Gwizdała ◽  
Franciszek Kasprzykowski ◽  
Leszek ŁaneKiewicz
Keyword(s):  
Circular Dichroism ◽  
Arginine Vasopressin ◽  
Circular Dichroïsm ◽  
Vasopressin Analogues

The Effects of Vasopressin and Vasopressin Analogues upon Renal Synthesis of Prostaglandins

1983 ◽  
pp. 151-166 ◽  
Author(s):  
Michael J. Dunn ◽  
Thomas R. Beck ◽  
Lewis B. Kinter ◽  
Aviv Hassid
Keyword(s):  
Vasopressin Analogues

Corticotropin Releasing Activity of Lysine Vasopressin Analogues

Endocrinology ◽  
1969 ◽  
Vol 84 (3) ◽  
pp. 579-583 ◽  
Author(s):  
A. ARIMURA ◽  
A. V. SCHALLY ◽  
C. Y. BOWERS
Keyword(s):  
Lysine Vasopressin ◽  
Vasopressin Analogues

Arginine-vasopressin analogues containing D-3-(3′-pyridyl)-alanine residue in position 2

Peptides 1992 ◽  
1993 ◽  
pp. 713-714
Author(s):  
Gotfryd Kupryszewski ◽  
Maria Sobocińska ◽  
Izabela Derdowska ◽  
Jeffrey Schwartz
Keyword(s):  
Arginine Vasopressin ◽  
Alanine Residue ◽  
Vasopressin Analogues

STRUCTURE-ACTIVITY RELATIONSHIPS OF VASOPRESSIN: SYNTHESES OF NEW VASOPRESSIN ANALOGUES

1987 ◽  
pp. 493-496
Author(s):  
Zbigniew Grzonka ◽  
Leszek Lankiewicz ◽  
Franciszek Kasprzykowski ◽  
Adam Liwo ◽  
Per Melin
Keyword(s):  
Structure Activity Relationships ◽  
Structure Activity ◽  
Vasopressin Analogues
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