Method for recording electrical activity of the sinoatrial node and automatic atrial foci during cardiac catheterization in human subjects

1980 ◽  
Vol 45 (4) ◽  
pp. 775-781 ◽  
Author(s):  
Robert J. Hariman ◽  
Ehud Krongrad ◽  
Robert A. Boxer ◽  
Melvin B. Weiss ◽  
Carl N. Steeg ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Cardiac Catheterization ◽  
Sinoatrial Node ◽  
Human Subjects

Effects of water ingestion on gastric electrical activity and heart-rate variability in healthy human subjects

1996 ◽  
Vol 58 (1-2) ◽  
pp. 44-50 ◽  
Author(s):  
Michio Watanabe ◽  
Yutaka Shimada ◽  
Shinya Sakai ◽  
Naotoshi Shibahara ◽  
Harumi Matsuda ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Electrical Activity ◽  
Human Subjects ◽  
Gastric Electrical Activity ◽  
Healthy Human ◽  
Water Ingestion ◽  
Healthy Human Subjects

Electrical Activity from the Superior Pharyngeal Constrictor During Reflexive and Nonreflexive Tasks

1989 ◽  
Vol 32 (4) ◽  
pp. 749-754 ◽  
Author(s):  
Adrienne L. Perlman ◽  
Erich S. Luschei ◽  
Charles E. Du Mond
Keyword(s):  
Electrical Activity ◽  
Healthy Subjects ◽  
General Trend ◽  
Human Subjects ◽  
Electrode Placement ◽  
Emg Activity ◽  
Constrictor Muscle ◽  
Natural Logarithm ◽  
Quantitative Manner ◽  
Normal Human

The purpose of this investigation was to determine, in a quantitative manner, which, if any, nonswallowing tasks produce significant levels of activation in the superior pharyngeal constrictor muscle of normal human subjects. Bipolar hooked wire electrodes were inserted in the superior pharyngeal constrictor muscle of 15 healthy subjects. Electrode placement was controlled. Each subject performed two reflexive tasks, six voluntary tasks requiring phonation, and four nonspeech voluntary tasks. The electromyogram (EMG) was rectified and integrated. The resulting number was then transformed by taking its natural logarithm. An ANOVA was performed and a linear model was estimated. The magnitude of the EMG activity was related to the location of the electrodes. The largest values were recorded in the lateral-superior placement, followed by the lateral-inferior, medial-inferior and medial-superior. The superior pharyngeal contrictor was found to be a muscle activated primarily during reflexive activity. There was a general trend in the amplitude of EMG activity in relationship to task. Swallowing produced the greatest amount of activity and a gag produced about 60% of the activity produced by the swallow. Two tasks, production of the work /hk/ in which the phoneme /k/ was stressed, and a "modified Valsalva," which was actually a hard /k/ held for several seconds, produced the next greatest level of EMG.

Heart Failure Differentially Modulates the Effects of Ivabradine on the Electrical Activity of the Sinoatrial Node and Pulmonary Veins

2018 ◽  
Vol 24 (11) ◽  
pp. 763-772 ◽  
Author(s):  
Chao-Shun Chan ◽  
Yao-Chang Chen ◽  
Shih-Lin Chang ◽  
Yung-Kuo Lin ◽  
Yu-Hsun Kao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Electrical Activity ◽  
Sinoatrial Node ◽  
Pulmonary Veins

Anatomy and physiology of the sinus node

ESC CardioMed ◽  
2018 ◽  
pp. 1940-1943
Author(s):  
Antonio Zaza
Keyword(s):  
Electrical Activity ◽  
Temporal Variability ◽  
Sinoatrial Node ◽  
Sinus Node ◽  
Membrane Current ◽  
Membrane Channels ◽  
Autonomic Balance ◽  
Electrical Excitation ◽  
Anatomy And Physiology ◽  
Mammalian Heart

The sinoatrial node (SAN) is the dominant pacemaker structure in the mammalian heart. It is endowed with robust intrinsic automaticity, providing periodic electrical excitation with a cycle widely modulated by autonomic influences. A number of membrane channels and transporters contribute to the net membrane current supporting SAN electrical activity, whose periodicity is determined by the interplay of two oscillators termed ‘membrane’ and ‘calcium’ clock respectively. This chapter describes the structure of the SAN, the peculiarities of its electrical cycle, the nature and modulation of the underlying clocks, and SAN interaction with atrial muscle. Moreover, the features and determinants of the temporal variability of the pacemaker cycle, clinically used to assess autonomic balance, are briefly discussed.

scholarly journals Heart Failure Differentially Modulates Natural (Sinoatrial Node) and Ectopic (Pulmonary Veins) Pacemakers: Mechanism and Therapeutic Implication for Atrial Fibrillation

2019 ◽  
Vol 20 (13) ◽  
pp. 3224 ◽  
Author(s):  
Chao-Shun Chan ◽  
Yung-Kuo Lin ◽  
Yao-Chang Chen ◽  
Yen-Yu Lu ◽  
Shih-Ann Chen ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Electrical Activity ◽  
Sinoatrial Node ◽  
Sick Sinus Syndrome ◽  
Pulmonary Veins ◽  
Calcium Handling ◽  
Adrenergic Stimulation ◽  
Therapeutic Implications ◽  
Cardiac Filling

Heart failure (HF) frequently coexists with atrial fibrillation (AF) and dysfunction of the sinoatrial node (SAN), the natural pacemaker. HF is associated with chronic adrenergic stimulation, neurohormonal activation, abnormal intracellular calcium handling, elevated cardiac filling pressure and atrial stretch, and fibrosis. Pulmonary veins (PVs), which are the points of onset of ectopic electrical activity, are the most crucial AF triggers. A crosstalk between the SAN and PVs determines PV arrhythmogenesis. HF has different effects on SAN and PV electrophysiological characteristics, which critically modulate the development of AF and sick sinus syndrome. This review provides updates to improve our current understanding of the effects of HF in the electrical activity of the SAN and PVs as well as therapeutic implications for AF.

The effects of intracellular calcium dynamics on the electrical activity of the cells of the sinoatrial node

BIOPHYSICS ◽  
2016 ◽  
Vol 61 (6) ◽  
pp. 893-900 ◽  
Author(s):  
A. D. Khokhlova ◽  
R. A. Syunyaev ◽  
A. M. Ryvkin ◽  
D. V. Shmarko ◽  
M. A. Gonotkov ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Intracellular Calcium ◽  
Sinoatrial Node ◽  
Calcium Dynamics ◽  
Intracellular Calcium Dynamics

Analysis of Evoked and Ongoing Electrical Activity at the Scalp of Human Subjects

1965 ◽  
Vol 8 (4) ◽  
pp. 371-387 ◽  
Author(s):  
Donald C. Teas
Keyword(s):  
Electrical Activity ◽  
Background Activity ◽  
Human Subjects ◽  
Low Frequency ◽  
Wide Band ◽  
Repeated Testing ◽  
Eyes Closed ◽  
Band Noise ◽  
The Subject ◽  
Wide Band Noise

Electrical activity at two locations on the scalp (Vertex and Vertex-3 cm, midline) for an experimental design suitable to clinical application, was recorded on magnetic tape. Data from 5 subjects with normal hearing, for 3 testing days, were processed. Average evoked responses to bursts of wide-band noise (30 dB and 50 dB SL) for two conditions (“eyes closed” and “reading”) were computed. The ongoing background activity was processed by computing its interval histogram. The percentage of ongoing activity within the frequency range 1.5 cps to 17 cps was extracted, and the magnitude of the N 1 -P 2 component of average responses was measured. These measures at the two electrode sites were analyzed by calculating analyses of variance for each of the four sets of data. Percentage of low-frequency background activity and N 1 -P 2 magnitude were positively related only for Day 1. A strong habituation effect appeared for Day 2 and Day 3. Habituation reduced differences between the two conditions and also differences between the two signal strengths for the average responses. Maximum N 1 -P 2 magnitude should be recorded for a single test with the subject relaxed and with his “eyes closed.” For repeated testing a discrimination between signals should be required to offset the attenuation of responses by habituation.

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