The relationship of maternal fetal hemoglobin level to perinatal outcome in pregnancies with sickle cell disease

1995 ◽  
Vol 172 (1) ◽  
pp. 336
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Perinatal Outcome ◽  
Fetal Hemoglobin ◽  
Hemoglobin Level ◽  
Cell Disease ◽  
Relationship Of ◽  
The Relationship ◽  
Fetal Hemoglobin Level

Association of fetal hemoglobin level with frequency of acute pain episodes in sickle cell disease (HbS-only phenotype) patients

2019 ◽  
Vol 75 ◽  
pp. 30-34 ◽  
Author(s):  
Bimal Prasad Jit ◽  
Pradeep Kumar Mohanty ◽  
Prasanta Purohit ◽  
Kishalaya Das ◽  
Siris Patel ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Acute Pain ◽  
Fetal Hemoglobin ◽  
Hemoglobin Level ◽  
Cell Disease ◽  
Fetal Hemoglobin Level

scholarly journals High fetal hemoglobin level is associated with increased risk of cerebral vasculopathy in children with sickle cell disease in Mayotte

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Abdourahim Chamouine ◽  
Thoueiba Saandi ◽  
Mathias Muszlak ◽  
Juliette Larmaraud ◽  
Laurent Lambrecht ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Fetal Hemoglobin ◽  
Hemoglobin Level ◽  
Cell Disease ◽  
Increased Risk ◽  
Fetal Hemoglobin Level

scholarly journals Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease

Blood ◽  
2009 ◽  
Vol 114 (21) ◽  
pp. 4639-4644 ◽  
Author(s):  
Victor R. Gordeuk ◽  
Andrew Campbell ◽  
Sohail Rana ◽  
Mehdi Nouraie ◽  
Xiaomei Niu ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Tricuspid Regurgitation ◽  
Fetal Hemoglobin ◽  
Hemoglobin Concentration ◽  
Systolic Pulmonary Artery Pressure ◽  
Cell Disease ◽  
Hemoglobin F ◽  
Hydroxyurea Treatment ◽  
Relationship Of

AbstractHydroxyurea and higher hemoglobin F improve the clinical course and survival in sickle cell disease, but their roles in protecting from pulmonary hypertension are not clear. We studied 399 children and adolescents with sickle cell disease at steady state; 38% were being treated with hydroxyurea. Patients on hydroxyurea had higher hemoglobin concentration and lower values for a hemolytic component derived from 4 markers of hemolysis (P ≤ .002) but no difference in tricuspid regurgitation velocity compared with those not receiving hydroxyurea; they also had higher hemoglobin F (P < .001) and erythropoietin (P = .012) levels. Hemoglobin F correlated positively with erythropoietin even after adjustment for hemoglobin concentration (P < .001). Greater hemoglobin F and erythropoietin each independently predicted higher regurgitation velocity in addition to the hemolytic component (P ≤ .023). In conclusion, increase in hemoglobin F in sickle cell disease may be associated with relatively lower tissue oxygen delivery as reflected in higher erythropoietin concentration. Greater levels of erythropoietin or hemoglobin F were independently associated with higher tricuspid regurgitation velocity after adjustment for degree of hemolysis, suggesting an independent relationship of hypoxia with higher systolic pulmonary artery pressure. The hemolysis-lowering and hemoglobin F–augmenting effects of hydroxyurea may exert countervailing influences on pulmonary blood pressure in sickle cell disease.

The Effect of Sickle Cell Genetic Markers on Geographic Distribution and Relation to Pain Outcomes in the Multicenter Study of Hydroxyurea in Sickle Cell Anemia

2011 ◽  
Vol 07 (01) ◽  
pp. 64
Author(s):  
Samir K Ballas ◽  
Robert L Bauserman ◽  
William F McCarthy ◽  
Myron A Waclawiw ◽  
◽  
...  
Keyword(s):  
Genetic Markers ◽  
Sickle Cell ◽  
Multicenter Study ◽  
Fetal Hemoglobin ◽  
Hemoglobin Level ◽  
Future Research ◽  
Cell Disease ◽  
Pain Outcomes ◽  
Treatment Responder ◽  
Fetal Hemoglobin Level

Some genetic markers known to play a role in sickle cell disease were associated with classification as a treatment responder, pain-related outcomes, and equi-analgesic dosing in the Multicenter Study of Hydroxurea (MSH) cohort. However, when examined by sex, associations with equi-analgesic dosing were statistically significant for males only. Factors that increase the hemoglobin/hematocrit levels seem not to be beneficial. Future research should focus on factors that increase fetal hemoglobin level.

scholarly journals The Relationship of Transcranial Doppler Ultrasonography with Attention, Motor, and Social-Emotional Functioning in Pediatric Sickle Cell Disease

2019 ◽  
Vol 34 (6) ◽  
pp. 842-842
Author(s):  
M Balderrama ◽  
C Merrill ◽  
A Whitaker ◽  
K Kayser
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Transcranial Doppler ◽  
Emotional Functioning ◽  
Neuropsychological Functioning ◽  
Cell Disease ◽  
Social Emotional ◽  
Social Emotional Functioning ◽  
Relationship Of ◽  
The Relationship

Abstract Objective Children with sickle cell disease (SCD) are at greater risk for certain neuropsychological deficits due to their medical condition and associated complications. Previous studies have explored the relationship between Transcranial Doppler (TCD) ultrasonography and various domains of neuropsychological functioning in pediatric SCD populations; however, these studies are dated, present variable and inconsistent findings, and are somewhat limited in scope. The goal of this study was to update and expand upon previous research by examining the predictive relationship of TCD results with measures of attention, motor, and social-emotional functioning. Methods Thirty-six patients ages 3-19 with SCD with no known history of stroke, with TCD completed within the past 12 months, underwent a brief neuropsychological exam. Attention, motor, and social-emotional functioning were assessed as appropriate for age using the Conners Continuous Performance Test (K-CPT2/CPT3), Purdue Pegboard, and PROMIS, respectively. TCD values were gathered via medical record review, using the highest value of most recent TCD. Results TCD significantly predicted certain aspects of attention and motor ability, but not social-emotional functioning. Specifically, TCD significantly predicted Detectability (p = .005), Omissions (p = .001), Commissions (p = .012), Perseverations (p = .035), and HRT SD (p = .046) on K-CPT2/CPT-3 and the non-dominant (p = .009) and bilateral (p = .024) trial scores on the Purdue Pegboard. Conclusion This study provides new evidence that TCD may be predictive of motor functioning in pediatric SCD. Results confirm that TCD is predictive of attentional function, though subdomains impacted varied from previous research. While no significant relationship between psychosocial symptoms and TCD were identified, further studies utilizing more comprehensive measurement within this domain is warranted.

Sign in / Sign up

Export Citation Format

Share Document