Refractive Change as the Initial Sign of Progressive Facial Hemiatrophy

Primary immunodeficiency disorders, such as ataxia-telangiectasia (A-T), may rarely be associated with cutaneous granulomas without an identifiable infection. The authors report a case of a 3-year-old boy with A-T who presented with two persistent ulcerated erythematous nodules. Histopathology was consistent with a granulomatous process secondary to A-T, without an infectious origin. Partial improvement was noted with clobetasol propionate 0.05% cream applied twice daily under occlusion. Of note, the presence of multiple noninfectious granulomas in a child may be the initial sign of an immune deficiency and should alert the astute clinician to investigate for an underlying primary immunodeficiency. Herein, the authors discuss the associations of noninfectious granulomas and primary immunodeficiency disorders and present management options for these difficult-to-treat lesions.

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Bone marrow abnormalities detected by magnetic resonance imaging as initial sign of hematologic malignancies

Clinics and Practice ◽

10.4081/cp.2018.1061 ◽

2018 ◽

Cited By ~ 1

Author(s):

Ida Sofie Grønningsæter ◽

Aymen Bushra Ahmed ◽

Nils Vetti ◽

Silje Johansen ◽

Øystein Bruserud ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Bone Marrow ◽

Magnetic Resonance ◽

Case Reports ◽

Cell Types ◽

Hematologic Malignancies ◽

Resonance Imaging ◽

Initial Sign ◽

Magnetic Resonance Imaging Mri

The increasing use of radiological examination, especially magnetic resonance imaging (MRI), will probably increase the risk of unintended discovery of bone marrow abnormalities in patients where a hematologic disease would not be expected. In this paper we present four patients with different hematologic malignancies of nonplasma cell types. In all patients the MRI bone marrow abnormalities represent an initial presentation of the disease. These case reports illustrate the importance of a careful diagnostic follow-up without delay of patients with MRI bone marrow abnormalities, because such abnormalities can represent the first sign of both acute promyelocytic leukemia as well as other variants of acute leukemia.

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Facial Hemiatrophy*

American Journal of Ophthalmology ◽

10.1016/s0002-9394(39)91790-3 ◽

1939 ◽

Vol 22 (1) ◽

pp. 1-10 ◽

Cited By ~ 7

Author(s):

Frank B. Walsh

Keyword(s):

Facial Hemiatrophy

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Refractive change and stability after Descemet membrane endothelial keratoplasty

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2011.02.033 ◽

2011 ◽

Vol 37 (8) ◽

pp. 1455-1464 ◽

Cited By ~ 69

Author(s):

Lisanne Ham ◽

Isabel Dapena ◽

Kyros Moutsouris ◽

Chandra Balachandran ◽

Laurence E. Frank ◽

...

Keyword(s):

Endothelial Keratoplasty ◽

Descemet Membrane Endothelial Keratoplasty ◽

Descemet Membrane ◽

Refractive Change

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Keep an Eye Out for Crohn’s Disease: Orbital Myositis as the Initial Sign before Gastrointestinal Manifestations

European Journal of Case Reports in Internal Medicine ◽

10.12890/2020_001964 ◽

2020 ◽

Author(s):

Gilles Jadd Hoilat ◽

Abinash Subedi ◽

Mohamad Fekredeen Ayas ◽

Nuri Ozden

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Pseudotumor Cerebri ◽

Extraintestinal Manifestations ◽

Gastrointestinal Manifestations ◽

Orbital Myositis ◽

Ocular Manifestations ◽

Initial Sign ◽

Intestinal Symptoms ◽

Work Up

Extraintestinal manifestations of Crohn's disease sometimes occur and can present prior to intestinal symptoms. Ocular manifestations of Crohn's disease are considered rare, with orbital myositis an even rarer manifestation with only a handful of cases reported in the literature. We present the case of a young woman who was diagnosed with orbital myositis, which was initially attributed to pseudotumor cerebri after an extensive negative work-up. Months later, the patient presented with haematochezia, and was subsequently diagnosed with Crohn's disease.

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