Long-lasting follow-up favours a close relationship between progressive facial hemiatrophy and scleroderma en coup de sabre*

2005 ◽  
Vol 19 (4) ◽  
pp. 403-404 ◽  
Author(s):  
S Jablonska ◽  
M Blaszczyk
Keyword(s):  
Close Relationship ◽  
Facial Hemiatrophy

scholarly journals Cycle length of nonsustanied ventricular tachycardias among ICD patients: implications on subsequent appropriate therapies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Javier Jiménez-Candil ◽  
Olga Duran ◽  
Armando Oterino ◽  
Jendri Pérez ◽  
Juan Carlos Castro ◽  
...  
Keyword(s):  
At Risk ◽  
Secondary Prevention ◽  
Beta Blocker ◽  
Cycle Length ◽  
Close Relationship ◽  
Appropriate Therapy ◽  
The Mean ◽  
Ventricular Tachycardias ◽  
The Relationship

Abstract Background ICD patients with episodes of nonsustained ventricular tachycardias (NSVT) are at risk of appropriate therapies. However, the relationship between the cycle length (CL) of such NSVTs and the subsequent incidence of appropriate interventions is unknown. Methods 416 ICD patients with LVEF < 45% were studied. ICD programming was standardized. NSVT was defined as any VT of 5 or more beats at ≥ 150 bpm occurred in the first 6 months after implantation that terminated spontaneously and was not preceded by any appropriate therapy. The mean follow-up was 41 ± 27 months. Results We analyzed 2201 NSVTs (mean CL = 323 ms) that occurred in 250 patients; 111 of such episodes were fast (CL ≤ 300 ms). Secondary prevention (HR = 1.7; p < 0.001), number of NSVT episodes (HR = 1.05; 95% CI 1.04–1.07; p < 0.001) and beta-blocker treatment (HR = 0.7; p = 0.04) were independent predictors of appropriate interventions; however, the mean CL of NSVTs was not (p = 0.6). There was a correlation between the mean CL of NSVTs and the CL of the first monomorphic VT: r = 0.88; p < 0.001. This correlation was especially robust in individuals with > 5 NSVTs (r = 0.97; p < 0.001), with an agreement between both values greater than 95%. Patients with any fast NSVT experienced a higher incidence of VF episodes (26%) compared to those without NVSTs (3%) or with only slow NSVTs (7%); p < 0.001. Conclusions Unlike the burden, the CL of NSVTs is not a predictor of subsequent appropriate interventions. However, there is a close relationship between the CL of NSVTs and that of arrhythmias that will later lead to appropriate therapies.

Berufsfelder und -chancen von Wirtschaftsgeographen

2013 ◽  
Vol 57 (1-2) ◽  
Author(s):  
Rolf Sternberg
Keyword(s):  
Economic Geography ◽  
Work Conditions ◽  
University Education ◽  
University Teaching ◽  
Follow Up Study ◽  
Career Opportunities ◽  
Close Relationship ◽  
The University ◽  
Good Career

Occupational fields and career prospects of economic geographers. Empirical evidence from a graduate follow-up study at the Leibniz Universität Hannover and conclusions for teaching at universities. The employability of the alumni has become an important aspect of university teaching in Germany since bachelor and master courses were introduced some years ago. This also applies for the university education of economic geographers. The paper demonstrates the increased and still increasing relevance of employability for economic geographers studying at German universities. Based on data for 295 economic geography graduates from the Leibniz Universität Hannover it is shown that such alumni have rather good career opportunities to achieve both high income and satisfying work conditions. Adequate specialization of the curriculum, excellence in teaching and research, and a close relationship between university teaching (and teachers) and the professional world outside the university are important conditions for successful alumni.

Levels of inflammatory markers and the development of the post-thrombotic syndrome

2009 ◽  
Vol 101 (03) ◽  
pp. 505-512 ◽  
Author(s):  
Hadia Shbaklo ◽  
Christina A. Holcroft ◽  
Susan R. Kahn
Keyword(s):  
Odds Ratio ◽  
Inflammatory Markers ◽  
Subsequent Development ◽  
Regression Analyses ◽  
Post Thrombotic Syndrome ◽  
Venous Valves ◽  
Markers Of Inflammation ◽  
Close Relationship ◽  
Study Population

SummaryThe post-thrombotic syndrome (PTS) occurs frequently after deep venous thrombosis (DVT) despite appropriate anticoagulant therapy. A close relationship between inflammation and thrombosis exists. While the inflammatory process at the time of DVT appears to improve thrombus resolution, it may promote destruction of venous valves, valvular reflux and subsequent development of PTS. We prospectively evaluated the association between levels of four cytokines (IL-6, IL-8, IL-10 and MCP-1), two adhesion molecules (ICAM-1 and VCAM-1) and the development of PTS in a well-defined cohort of patients with DVT. The study population consisted of 387 patients with objectively diagnosed symptomatic DVT who were followed for two years to determine the incidence of PTS. At the end of follow-up, plasma samples frozen at the four-month visit in 307 study patients were thawed and analyzed for the above inflammatory markers using the Luminex beads technology. Mean levels of IL-6 were significantly higher in patients with PTS compared to patients without PTS (7.35 pg/ml ± 14.26 [SD] vs. 4.60 pg/ml ± 4.90;p=0.03). Logistic regression analyses showed significant associations between PTS and levels above vs. below the median of IL-6 [odds ratio (OR) 1.66; 95% confidence interval (CI) 1.05, 2.62 (p=0.03)] and ICAM-1 [OR 1.63; 95% CI 1.03, 2.58 (p=0.04)]. None of the other markers showed any association with PTS. Our study suggests the presence of significant associations between markers of inflammation such as IL-6 and ICAM-1 and the development of PTS. Further work is needed to evaluate this relationship and to analyse other candidate markers that could be implicated etiologically in the association between DVT and PTS. If confirmed, this could lead to identification of new therapeutic targets for preventing PTS after DVT.

scholarly journals Palmaz Stent Deployment for Subclavian and Brachiocephalic Arterial Occlusive Disease

2001 ◽  
Vol 7 (1_suppl) ◽  
pp. 49-52 ◽  
Author(s):  
H. Nakagawa ◽  
K. Kichikawa ◽  
K. Takayama ◽  
M. Sakamoto ◽  
T. Wada ◽  
...  
Keyword(s):  
Intimal Hyperplasia ◽  
Statistical Significance ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Intimal Thickening ◽  
Relative Thickness ◽  
Stent Deployment ◽  
Close Relationship ◽  
Stent Diameter

Palmaz stent deployment is a useful method for subclavian and brachiocephalic arterial occlusive disease. We evaluated restenosis or intimal thickening after Palmaz stent deployment for nine lesions of subclavian or brachiocephalic arterial occlusive disease focusing on stent diameter, atheroma thickness near the stent, and degree of coverage for the lesion. Follow up DSA and IVUS at 5–14 months (mean 9) after therapy showed no significant changes in the size or shape of the stent itself. There were two lesions of thin in-stent intimal hyperplasia and five lesions of thick hyperplasia. There was no close relationship between intimal hyperplasia and stent diameter or atheroma size (relative thickness). There was some relationship between the degree of coverage of the lesion by the stent and degree of intimal hyperplasia, but to determine statistical significance, accumulation of a greater number of cases is necessary.

scholarly journals Acute Suppurative Sialadenitis Secondary to Excisional Ranula Biopsy in Child

2016 ◽  
Vol 5 (2) ◽  
pp. 123-126
Author(s):  
Tiago N Pinheiro ◽  
Juliana Arid ◽  
Aloizio P Maciel ◽  
André FM Machado ◽  
Marleno L Monteiro ◽  
...  
Keyword(s):  
Opportunistic Infections ◽  
Mandibular Gland ◽  
Excisional Biopsy ◽  
Preoperative Care ◽  
Antibacterial Prophylaxis ◽  
Biopsy Site ◽  
Close Relationship ◽  
The Right ◽  
Relationship Of

ABSTRACT Introduction Ranulas are lesions that affect the salivary glands, and they are generally treated by excision; however, they can recur in some cases where the gland is not removed and they may progress to acute suppurative sialadenitis, yet such cases are rare, especially in children. Aims To report clinical management of occurrence of acute suppurative sialadenitis secondary to excisional biopsy of ranula in a child. Case report An 11-year-old female patient was diagnosed with ranula where excisional biopsy was performed. Subsequently, the patient developed infection, suggesting Ludwig's angina, after reevaluation, she was diagnosed with acute suppurative sialadenitis in the right mandibular gland; during the follow-up period, antibiotic therapy was introduced. Conclusion The close relationship of the biopsy site with the submandibular space and other structures of the neck required the completion of antibacterial prophylaxis associated with preoperative care, transoperative care, and postoperative care to combat opportunistic infections and their subsequent complications. Clinical Significance Suppurative sialadenitis and its subsequent complications may be considered, although rare, as a complication in cases of ranula. How to cite this article Pinheiro TN, Arid J, Maciel AP, Machado AFM, Monteiro ML, de Oliveira Daltoé M, de Carvalho FK. Acute Suppurative Sialadenitis Secondary to Excisional Ranula Biopsy in Child. Int J Experiment Dent Sci 2016;5(2):123-126.

scholarly journals Metabolic Healthy Obesity is associated with higher incidence of mild decrease estimate glomerular rate in rural Northeast Chinese

2020 ◽  
Author(s):  
Shasha Yu ◽  
Xiaofan Guo ◽  
GuangXiao Li ◽  
Hongmei Yang ◽  
Liqiang Zheng ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Kidney Disease ◽  
Lower Risk ◽  
Blood Test ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Metabolic Phenotype ◽  
Disease Epidemiology ◽  
Close Relationship

Abstract Background Metabolic healthy obesity (MHO), as one phenotype of obesity, seems associate with lower risk of cardiovascular disease. However, MHO has close relationship with higher incidence of metabolic syndrome and diabetes. This study aims to investigate the prevalence of MHO at baseline, changes of obese metabolic phenotype at follow-up and its relationship with incidence of mildly reduced estimated glomerular filtration rate (eGFR) in rural Northeast Chinese. Methods The Chronic Kidney Disease Epidemiology (CKD-EPI) equation was used to calculate eGFR. 4903 participants aged ≥ 35 years with eGFR > 90 ml/min/1.73 m2 at baseline were enrolled and successfully followed up. All participants completed the questionnaires, anthropometric measurements, and blood test during baseline and follow-up. Mild renal dysfunction defined as mildly reduced eGFR between 60–90 ml/min/1.73 m2. Results The prevalence of MHO was 20.04% in baseline (18.97% for women and 21.11% for men) which was secondary to metabolic abnormal obesity (MAO) (24.4%, 27.2% for women and 21.5% for men). 38.4% of women and 38.90% of men experienced phenotype changes during follow-up. The cumulative incidence of mildly reduced eGFR in MHO was 20.1% (17.7% for women and 22.3% for men) which was also secondary to MAO (20.8%, 18.6% for women and 23.5% for men). After adjusted possible confounders, MHO was associated with higher incidence of mildly reduced eGFR among women [OR (95%CI) = 1.64 (1.18, 2.25)] and men [OR (95%CI) = 1.62 (1.24, 2.11)] whereas MAO was related with higher incidence of mildly reduced eGFR among men only [OR (95%CI) = 1.74 (1.32, 2.29)]. Conclusion MHO was associated with higher incidence of mildly reduced eGFR in both gender; however, there was a specific relationship between MAO and mildly reduced eGFR in men only. Therefore, it is necessary to monitoring kidney function among both MHO and MAO subjects.

scholarly journals Peritumoral brain edema in intracranial meningiomas: the emergence of vascular endothelial growth factor–directed therapy

2013 ◽  
Vol 35 (6) ◽  
pp. E2 ◽  
Author(s):  
Jack Hou ◽  
Varun R. Kshettry ◽  
Warren R. Selman ◽  
Nicholas C. Bambakidis
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Brain Edema ◽  
Antiangiogenic Therapy ◽  
Mass Effect ◽  
Vascular Endothelial ◽  
Close Relationship ◽  
Peritumoral Brain Edema ◽  
Endothelial Growth Factor

Meningioma is the second most common type of adult intracranial neoplasm. A substantial subset of patients present with peritumoral brain edema (PTBE), which can cause significant morbidity via mass effect, complicate surgical management, and impact the safety of stereotactic radiosurgery. Recent studies suggest a close relationship between vascular endothelial growth factor-A (VEGF-A) expression and PTBE development in meningiomas. The authors performed a systematic review of the literature on the pathogenesis of PTBE in meningiomas, the effectiveness of steroid therapy, the role played by VEGF-A, and the current clinical evidence for antiangiogenic therapy to treat peritumoral brain edema. Mounting evidence suggests VEGF-A is secreted directly by meningioma cells to induce angiogenesis and edemagenesis of tumoral as well as peritumoral brain tissue. The VEGF-A cascade results in recruitment of cerebral-pial vessels and disruption of the tumor-brain barrier, which appear to be requisite for VEGF-A to have an edemagenic effect. Results of preliminary clinical studies suggest VEGF-directed therapy has modest activity against recurrent and progressive meningioma growth but can alleviate PTBE in some patients. A comprehensive understanding of the VEGF-A pathway and its modulators may hold the key to an effective therapeutic approach to treating PTBE associated with meningiomas. Further clinical trials with larger patient cohorts and longer follow-up periods are warranted to confirm the efficacy of VEGF-directed therapy.

Interdisciplinary Approach to the Management of Intestinal Transplant Recipients: Evaluation, Discharge, and Lifetime Management

2005 ◽  
Vol 15 (1) ◽  
pp. 54-59
Author(s):  
Kate Samela ◽  
Erin Fennelly ◽  
Mary Brosnan ◽  
Jill Robinson
Keyword(s):  
Intestinal Failure ◽  
Interdisciplinary Approach ◽  
Open Communication ◽  
Optimal Care ◽  
Team Members ◽  
Close Relationship ◽  
Transplant Team ◽  
Intestinal Transplant

Patients suffering from intestinal failure present unique and difficult challenges to the transplant team. Augmenting the need for interdisciplinary teamwork is the higher incidence of death on the intestinal transplant waiting list. Successful management of this population requires an interdisciplinary approach at each stage of care, beginning with evaluation and continuing through discharge and lifetime management. A close relationship between patients, their caregivers, and all members of the transplant team is an essential component to successful lifetime management. Open communication between team members and unlimited accessibility to each other enables work flow to be managed efficiently, and enables the provision of optimal care. In this article, we describe the functions of the nonphysician clinical personnel needed to manage the intestinal transplant patient—beginning at the evaluation through lifetime follow-up care. The goal of each professional is the same: to restore the patient to the best quality of life possible.

scholarly journals Anemia, nutrition and ambulatory oxygen weaning in a cohort of oxygen-dependent premature infants.

2020 ◽  
Author(s):  
Adriana Montealegre ◽  
Nathalie Charpak
Keyword(s):  
Weight Gain ◽  
Preterm Infants ◽  
Exclusive Breastfeeding ◽  
Neonatal Intensive Care ◽  
Care Program ◽  
Oxygen Requirement ◽  
Antenatal Corticosteroids ◽  
Close Relationship ◽  
One Year

Background: In Bogotá, Colombia, oxygen-dependent (OD) preterm infants are home discharged in Kangaroo Position, to a Kangaroo Mother Care program (KMCP) with ambulatory oxygen, strict follow-up and oxygen weaning protocols. Objectives: 1) to describe growth and morbimortality up to 6 months of an OD preterm infants’ cohort. 2) to explore the association between oxygen requirement, perinatal history, Hb levels, transfusions, feeding patterns and growth. Methods: Prospective cohort study. Descriptive and multivariate analysis. Results: 445 patients were recruited with 33 weeks median gestational age (GA). 21% of mothers had preeclampsia, 50% infections and 77% received antenatal corticosteroids. Upon KMCP admission, median GA, chronological age and hospital stay were 36 weeks, 19 and 17 days, respectively; 55.6% of patients had neonatal sepsis and 66.6% were admitted to Neonatal Intensive Care Unit. Patients had on average 52 days with oxygen, a median of 3200g and 42 weeks GA at oxygen weaning. Median follow-up oxygen saturation was 94% with 0.016-0.5 l/min of oxygen. One-year mortality was 0.2% and attrition 20%. At 6 months, all patients had appropriate growth and 66% were breastfeeding. Multiple regression analysis showed that higher GA, Hb levels, weight gain, and exclusive breastfeeding decreased oxygen requirement whilst invasive ventilation and transfusions had the opposite effect (R2=0.48). Conclusions: In OD preterm infants, there is a close relationship between days of oxygen requirement and GA, mechanical ventilation, Hb levels at discharge, transfusions, exclusive breastfeeding and weight gain. Strict monitoring with established protocols in an ambulatory KMCP allows adequate growth and safe oxygen weaning.

scholarly journals Familial pineal tumours in two siblings

2015 ◽  
Vol 42 (S1) ◽  
pp. S45-S45
Author(s):  
FB Maroun ◽  
R Avery ◽  
E Walsh
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Tumours ◽  
Clinical Manifestations ◽  
The Other ◽  
Resonance Imaging ◽  
Von Hippel Lindau ◽  
Endocrine Neoplasia ◽  
Close Relationship

Background: The occurrence of familial brain tumours, particularly gliomas, hemangioblastomas in Von Hippel Lindau and other endocrine neoplasia, is well documented in the literature. On the other hand, familial pineal tumours are extremely rare and only a handful of cases have been reported. Methods and Results: Two female siblings presented at ages 12 and 15 with histories of progressive headaches. Neurological examination in each was completely normal. Magnetic Resonance Imaging confirmed the presence of cystic and solid lobulated pineal lesions with mild enhancement, consistent with pineocytoma, in both girls. Follow-up for 15 years in the first sibling and 4 years in the second showed no evolution in radiological or clinical manifestations. No active treatments have been carried out. Conclusion: The occurrence of familial pineal lesions raises the possibility of a close relationship between heredity and oncogenicity, and should be further explored.

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