Biomedical applications of analytical supercritical fluid separation techniques

1992 ◽  
Vol 200 (1) ◽  
pp. 7-19 ◽  
Author(s):  
Lily Q. Xie ◽  
Karin E. Markides ◽  
Milton L. Lee
2019 ◽  
Vol 96 ◽  
pp. 539-551 ◽  
Author(s):  
Michele Savaris ◽  
Charlene Silvestrin Celi Garcia ◽  
Mariana Roesch-Ely ◽  
João Antonio Pêgas Henriques ◽  
Venina dos Santos ◽  
...  

2021 ◽  
Vol 69 (10) ◽  
pp. 970-975
Author(s):  
Kazuhiro Yamamoto ◽  
Koichi Machida ◽  
Akira Kotani ◽  
Hideki Hakamata

Bioanalysis ◽  
2019 ◽  
Vol 11 (24) ◽  
pp. 2297-2318 ◽  
Author(s):  
Karen Segers ◽  
Sven Declerck ◽  
Debby Mangelings ◽  
Yvan Vander Heyden ◽  
Ann Van Eeckhaut

Metabolomics is the comprehensive study of small-molecule metabolites. Obtaining a wide coverage of the metabolome is challenging because of the broad range of physicochemical properties of the small molecules. To study the compounds of interest spectroscopic (NMR), spectrometric (MS) and separation techniques (LC, GC, supercritical fluid chromatography, CE) are used. The choice for a given technique is influenced by the sample matrix, the concentration and properties of the metabolites, and the amount of sample. This review discusses the most commonly used analytical techniques for metabolomic studies, including their advantages, drawbacks and some applications.


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