Effects of phorbol ester on cell growth inhibition by transforming growth factor β 1 in human hepatoma cell lines

1990 ◽  
Vol 171 (1) ◽  
pp. 91-96 ◽  
Author(s):  
Kenji Takaishi ◽  
Sumio Kawata ◽  
Nobuyuki Ito ◽  
Shinji Tamura ◽  
Yasuhiro Shirai ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Phorbol Ester ◽  
Transforming Growth Factor ◽  
Hepatoma Cell ◽  
Transforming Growth Factor Β ◽  
Human Hepatoma ◽  
Cell Growth Inhibition ◽  
Human Hepatoma Cell ◽  
Hepatoma Cell Lines

scholarly journals Modulation of c-mycExpression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines

1990 ◽  
Vol 81 (3) ◽  
pp. 216-219 ◽  
Author(s):  
Nobuyuki Ito ◽  
Sumio Kawata ◽  
Shinji Tamura ◽  
Kenji Takaishi ◽  
Ryuzo Saitoh ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Lines ◽  
Transforming Growth Factor ◽  
Hepatoma Cell ◽  
Transforming Growth Factor Β1 ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Hepatoma Cell Lines

scholarly journals Association of v-ErbA with Smad4 Disrupts TGF-β Signaling

2009 ◽  
Vol 20 (5) ◽  
pp. 1509-1519 ◽  
Author(s):  
Richard A. Erickson ◽  
Xuedong Liu
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Growth Inhibition ◽  
Transforming Growth Factor ◽  
Mechanistic Explanation ◽  
Transforming Growth Factor Β ◽  
Cell Growth Inhibition ◽  
Erythroleukemia Cells ◽  
Avian Erythroblastosis Virus

Disruption of the transforming growth factor-β (TGF-β) pathway is observed in the majority of cancers. To further understand TGF-β pathway inactivation in cancer, we stably expressed the v-ErbA oncoprotein in TGF-β responsive cells. v-ErbA participates in erythroleukemic transformation of cells induced by the avian erythroblastosis virus (AEV). Here we demonstrate that expression of v-ErbA was sufficient to antagonize TGF-β–induced cell growth inhibition and that dysregulation of TGF-β signaling required that v-ErbA associate with the Smad4 which sequesters Smad4 in the cytoplasm. We also show that AEV-transformed erythroleukemia cells were resistant to TGF-β–induced growth inhibition and that TGF-β sensitivity could be recovered by reducing v-ErbA expression. Our results reveal a novel mechanism for oncogenic disruption of TGF-β signaling and provide a mechanistic explanation of v-ErbA activity in AEV-induced erythroleukemia.

scholarly journals Growth factor receptors in human hepatoma cell lines.

Kanzo ◽  
1988 ◽  
Vol 29 (10) ◽  
pp. 1423-1424
Author(s):  
Yoshiharu MOTOO ◽  
Nobuyoshi TANAKA ◽  
Hirofumi KITAGAWA ◽  
Kenichi KOBAYASHI ◽  
Nobu HATTORI
Keyword(s):  
Growth Factor ◽  
Cell Lines ◽  
Hepatoma Cell ◽  
Growth Factor Receptors ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Hepatoma Cell Lines

Altered regulation of Src tyrosine kinase by transforming growth factor ?1 in a human hepatoma cell line

Hepatology ◽  
1998 ◽  
Vol 28 (3) ◽  
pp. 796-804 ◽  
Author(s):  
Kazuto Fukuda ◽  
Sumio Kawata ◽  
Shinji Tamura ◽  
Yukihiko Matsuda ◽  
Yoshiaki Inui ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Cell Line ◽  
Transforming Growth Factor ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Src Tyrosine Kinase ◽  
Altered Regulation
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