Adhesion of human cancer cells to vascular endothelium mediated by a carbohydrate antigen, sialyl Lewis A

1991 ◽  
Vol 179 (2) ◽  
pp. 713-719 ◽  
Author(s):  
Akiko Takada ◽  
Katsuyuki Ohmori ◽  
Naofumi Takahashi ◽  
Kiyotaka Tsuyuoka ◽  
Akihiro Yago ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Vascular Endothelium ◽  
Human Cancer ◽  
Carbohydrate Antigen ◽  
Human Cancer Cells ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

Adhesion of Human Cancer Cells to Vascular Endothelium Mediated by a Carbohydrate Antigen, SPan-1

1993 ◽  
pp. 743-745
Author(s):  
Nobuya Yamada ◽  
Yong-Suk Chung ◽  
Yoshito Yamashita ◽  
Naoyoshi Onoda ◽  
Kiyoshi Maeda ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Vascular Endothelium ◽  
Human Cancer ◽  
Carbohydrate Antigen ◽  
Human Cancer Cells

scholarly journals Expression of carbohydrate-antigen sialyl-Lewis a on colon cancer cells promotes xenograft growth and angiogenesis in nude mice

2013 ◽  
Vol 45 (12) ◽  
pp. 2796-2800 ◽  
Author(s):  
Laura Terraneo ◽  
Laura Avagliano ◽  
Anna Caretti ◽  
Paola Bianciardi ◽  
Delfina Tosi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Nude Mice ◽  
Carbohydrate Antigen ◽  
Colon Cancer Cells ◽  
Xenograft Growth ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

scholarly journals Sialyl Lewis(a): a tumor-associated carbohydrate antigen involved in adhesion and metastatic potential of cancer cells.

2002 ◽  
Vol 49 (2) ◽  
pp. 303-311 ◽  
Author(s):  
Maciej Ugorski ◽  
Anna Laskowska
Keyword(s):  
Cancer Cells ◽  
Tumor Cells ◽  
Human Cancer ◽  
Metastatic Potential ◽  
Sialyl Lewis X ◽  
Adhesion Assay ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

Neoplastic transformation is often associated with characteristic changes in the expression of the sialyl Lewis(a) and sialyl Lewis(x) antigens, representing typical tumor-associated carbohydrate antigens. High amounts of sialyl Lewis(a) are present in human adenocarcinomas of the colon, pancreas and stomach. A growing amount of data suggests that this carbohydrate structure is the ligand for E-selectin. Sialylated Lewis structures present on the surface of tumor cells are carried by the carbohydrate chains of glycoproteins and glycolipids. There are several lines of evidence showing that sialyl Lewis(a) is responsible for the adhesion of human cancer cells to endothelium. E-selectin present on endothelial cells mediates these interactions. Selectins and their carbohydrate ligands can thus play an important role in the selective homing of tumor cells during metastasis. However, the presence of sialyl Lewis(a) antigen on the surface of tumor cells and their adhesion to E-selectin-expressing cells in in vitro adhesion assay by itself can not be directly related to metastatic properties of all cancer cells.

Significance of Carbohydrate Antigen Sialyl-Lewis X, Sialyl-Lewis A, and Possible Unknown Ligands to Adhesion of Human Urothelial Cancer Cells to Activated Endothelium

2000 ◽  
Vol 64 (3) ◽  
pp. 129-133 ◽  
Author(s):  
Yasuhisa Fujii ◽  
Masayuki Yoshida ◽  
Lee-Jung Chien ◽  
Kazunori Kihara ◽  
Yukio Kageyama ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Urothelial Cancer ◽  
Carbohydrate Antigen ◽  
Sialyl Lewis X ◽  
Lewis X ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

Target-selective photo-degradation of a sialyl Lewis a (sLea) conjugate and photo-cytotoxicity against sLea positive cancer cells using an anthraquinone-antibody hybrid

MedChemComm ◽  
2016 ◽  
Vol 7 (6) ◽  
pp. 1224-1228 ◽  
Author(s):  
Daisuke Takahashi ◽  
Takashi Nagao ◽  
Shota Sotokawa ◽  
Kazunobu Toshima
Keyword(s):  
Monoclonal Antibody ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Cancer Cells ◽  
Photo Degradation ◽  
Sialyl Lewis ◽  
Sialyl Lewis A ◽  
Lewis A

A purpose-designed anthraquinone–monoclonal antibody (anti-sialyl Lewis A (sLea) mAb) hybrid 6 selectively bound to and effectively degraded the target glycoprotein, HSA (human serum albumin)–sLea conjugate 4.

Indirubin derivatives inhibit SFKs/Stat signaling associated with apoptosis in human cancer cells

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
S Nam ◽  
R Buettner ◽  
X Liu ◽  
J Turkson ◽  
D Kim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Human Cancer Cells ◽  
Stat Signaling
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