Study of biochemical effects of anti-inflammatory drugs in carrageenin induced oedema and cotton pellet granuloma

ABSTRACTObjective: To evaluate the anti-inflammatory activity of sodium valproate and docosahexaenoic acid (DHA) supplementation using variousexperimental models in albino Wistar rats.Method: A total of 48 adult Wistar albino male rats were divided into 8 groups of 6 rats each. Group I was control (distilled water 1 ml/kg), Group IIreceived intraperitoneal (i.p.) injection of indomethacin (10 mg/kg), Groups III-V were injected (i.p.) with sodium valproate 100, 200, and 400 mg/kgwater, and Groups VI-VIII were given sodium valproate 100, 200, and 400 mg/kg plus DHA 300 mg/kg (i.p.), respectively. Anti-inflammatory activitywas assessed using carrageenan induced paw edema and the cotton pellet granuloma models.Results: We found that higher doses of sodium valproate (400 mg/kg) used either alone or with a combination of DHA (300 mg/kg) showed asignificant anti-inflammatory activity when compared to control in both the models of inflammation.Conclusion: Combination of sodium valproate along DHA has shown promising anti-inflammatory activity.Keywords: Anti-inflammatory drugs, Sodium valproate, Rat model.

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URINARY EXCRETION OF VANILLYLMANDELIC ACID AND EFFECT OF SOME ANTI-INFLAMMATORY DRUGS IN COTTON PELLET INFLAMMATION

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)64751-7 ◽

1981 ◽

Vol 31 (5) ◽

pp. 860-862

Author(s):

Eiichi KAYAMA ◽

Kenji YAMADA ◽

Yoshio AIZAWA

Keyword(s):

Urinary Excretion ◽

Vanillylmandelic Acid ◽

Cotton Pellet ◽

Inflammatory Drugs ◽

Anti Inflammatory

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Preliminary Analysis of the Anti-Inflammatory Activity of Essential Oils of Zingiber zerumbet

Biological Research For Nursing ◽

10.1177/1099800410386590 ◽

2010 ◽

Vol 13 (4) ◽

pp. 425-432 ◽

Cited By ~ 9

Author(s):

Z. A. Zakaria ◽

A. S. Mohamad ◽

M. S. Ahmad ◽

A. F. Mokhtar ◽

D. A. Israf ◽

...

Keyword(s):

Side Effects ◽

Essential Oil ◽

Preliminary Analysis ◽

Formalin Test ◽

Inflammatory Activity ◽

Paw Edema ◽

Zingiber Zerumbet ◽

Cotton Pellet ◽

Inflammatory Drugs ◽

Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments.

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