Preliminary Analysis of the Anti-Inflammatory Activity of Essential Oils of Zingiber zerumbet

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments.

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Anti-inflammatory Activity of Pistacia lentiscus Essential Oil: Involvement of IL-6 and TNF-α

Natural Product Communications ◽

10.1177/1934578x1100601033 ◽

2011 ◽

Vol 6 (10) ◽

pp. 1934578X1100601 ◽

Cited By ~ 2

Author(s):

Andrea Maxia ◽

Cinzia Sanna ◽

Maria Assunta Frau ◽

Alessandra Piras ◽

Manvendra Singh Karchuli ◽

...

Keyword(s):

Essential Oil ◽

Inflammatory Activity ◽

Pistacia Lentiscus ◽

Paw Edema ◽

Rat Paw Edema ◽

Tnf Α ◽

Cotton Pellet ◽

Anti Inflammatory ◽

Factor Α ◽

Rat Paw

The topical anti-inflammatory activity of essential oil of Pistacia lentiscus L. was studied using carrageenan induced rat paw edema and cotton pellet induced granuloma. The effect on serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats inserted with cotton pellet was also investigated. On topical application, the oil exhibited a significant decrease in paw edema. The oil also inhibited cotton pellet-induced granuloma, and reduced serum TNF-α and IL-6. It can be concluded that the essential oil of Pistacia lentiscus reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.

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Sesquiterpenes from Essential Oils and Anti-Inflammatory Activity

Natural Product Communications ◽

10.1177/1934578x1501001033 ◽

2015 ◽

Vol 10 (10) ◽

pp. 1934578X1501001 ◽

Cited By ~ 2

Author(s):

Rita de Cássia Da Silveira e Sá ◽

Luciana Nalone Andrade ◽

Damião Pergentino De Sousa

Keyword(s):

Side Effects ◽

Essential Oil ◽

Therapeutic Potential ◽

Relevant Information ◽

Mechanisms Of Action ◽

Experimental Models ◽

Inflammatory Activity ◽

Chemical Structures ◽

Inflammatory Drugs ◽

Anti Inflammatory

This review is aimed at presenting relevant information on the therapeutic potential of essential oil sesquiterpenes with anti-inflammatory activity. The data reviewed provide a basis for seeking new anti-inflammatory drugs from natural products that do not exhibit the undesirable side effects often displayed by anti-inflammatory drugs. In this review the experimental models, possible mechanisms of action, and chemical structures of 12 sesquiterpenes are presented.

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Essential Oil of Myrtus communis Inhibits Inflammation in Rats by Reducing Serum IL-6 and TNF-α

Natural Product Communications ◽

10.1177/1934578x1100601034 ◽

2011 ◽

Vol 6 (10) ◽

pp. 1934578X1100601 ◽

Cited By ~ 8

Author(s):

Andrea Maxia ◽

Maria Assunta Frau ◽

Danilo Falconieri ◽

Manvendra Singh Karchuli ◽

Sanjay Kasture

Keyword(s):

Essential Oil ◽

Inflammatory Activity ◽

Myrtus Communis ◽

Ear Edema ◽

Tnf Α ◽

Cotton Pellet ◽

Anti Inflammatory ◽

Factor Α ◽

Necrosis Factor ◽

Serum Tumor Necrosis

The topical anti-inflammatory activity of the essential oil of Myrtus communis L. was studied using croton oil induced ear edema and myeloperoxidase (MPO) activity in mice, and cotton pellet induced granuloma, and serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in rats. On topical application, the oil exhibited a significant decrease in the ear edema as well as MPO activity. The oil also inhibited cotton pellet-induced granuloma and serum TNF-α and IL-6. It can be concluded that the essential oil of Myrtus communis reduces leukocyte migration to the damaged tissue and exhibits anti-inflammatory activity.

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Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models

Medical Principles and Practice ◽

10.1159/000488199 ◽

2018 ◽

Vol 27 (3) ◽

pp. 267-271 ◽

Cited By ~ 1

Author(s):

Mohammed Safwan Ali Khan ◽

Nishath Khatoon ◽

Mohammad M. Al-Sanea ◽

Mohamed Gamal Mahmoud ◽

Hidayat Ur Rahman

Keyword(s):

Methanolic Extract ◽

Test Dose ◽

Inflammatory Activity ◽

Paw Edema ◽

Standard Drug ◽

Inflammatory Models ◽

Cotton Pellet ◽

Wet Weight ◽

Granulomatous Tissue ◽

Anti Inflammatory

Objective: The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. Materials and Methods: A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at 3 oral test doses (125, 250, and 500 mg/kg). Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellets were determined. The data were analyzed by one-way ANOVA followed by Dunnett’s multiple comparison test. Results: The test extract at doses of 125 and 250 mg/kg decreased paw volume and wet and dry weights of cotton pellets. The highest test dose (500 mg/kg) displayed a response comparable to that of the standard drug (p < 0.01) on paw volume. The extract produced similar (p < 0.05) decrease in wet weight of the cotton pellet at 125 and 250 mg/kg, whereas the effect of 500 mg/kg of the extract was comparable to that of aspirin 100 mg/kg (p < 0.01). The extract of T. coriacea at 500 mg/kg induced the most significant (p < 0.01) effect on wet weight of granulomatous tissue. Conclusion: The methanolic extract of T. coriacea leaves successfully decreased paw edema as well as dry and wet weights of granulomatous tissue in both acute and chronic inflammatory models thus confirming the anti- edematogenic, antitransudative, and antiproliferative properties of T. coriacea.

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Synthesis, Anti-Inflammatory Activity and Molecular Docking Studies of 1,4,5,6-Tetrahydropyrimidine-2-Carboxamides

Pharmaceutical Sciences ◽

10.34172/ps.2020.100 ◽

2020 ◽

Vol 27 (3) ◽

pp. 353-365

Author(s):

Volodymyr Ya. Horishny ◽

Pavlo V. Zadorozhnii ◽

Ivanna V. Horishnia ◽

Vasyl S. Matiychuk

Keyword(s):

Molecular Docking ◽

Side Effects ◽

Docking Studies ◽

Inflammatory Activity ◽

Cox Inhibitors ◽

White Rats ◽

Urgent Task ◽

Inflammatory Drugs ◽

Anti Inflammatory

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. The widespread use of NSAIDs is associated with a number of serious side effects and complications observed for both selective and non-selective COX inhibitors. Therefore, the search for new COX inhibitors, which along with their effectiveness will have minimal side effects, is a very important and urgent task. Methods: This work studied the synthesis of new 1,4,5,6-tetrahydropyrimidine-2-carboxamides based on the reaction of 2-morpholin-4-yl-N-(het)aryl-2-thioxoacetamides with 1,3-diaminopropane. All obtained compounds were tested for anti-inflammatory activity in vitro and in silico conditions. All synthesized 1,4,5,6-tetrahydropyrimidine-2-carboxamides were tested for influence on the course of the exudative phase of the inflammatory process based on the carrageenan model of paw edema of laboratory nonlinear heterosexual white rats weighing 220-250 g, using Diclofenac as a reference. Optimization of the geometry of the studied structures and molecular docking was carried out using the ArgusLab 4.0.1 software package. Results: The target products were obtained with yields of 71-98% and easily isolated from the reaction mixture. The best anti-inflammatory activity was found in N-(4-chlorophenyl)-1,4,5,6-tetrahydropyrimidine-2-carboxamide and in N-[4-chloro-3-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydropyrimidine-2-carboxamide, suppression of the inflammatory response was 46.7 and 46.4%, respectively. The results of molecular docking with COX-1 and COX-2 enzymes were in good agreement with the experimental data, R2 ˃ 0.92 and R2 ˃ 0.83, respectively. Conclusion: The compounds under study were shown to be promising as potential anti-inflammatory agents.

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Anti-inflammatory activities of ethanol leaves extract and solvent fractions of Zehneria scabra (Cucurbitaceae) in rodents

Asian Journal of Natural Product Biochemistry ◽

10.13057/biofar/f180105 ◽

2020 ◽

Vol 18 (1) ◽

Author(s):

REDIET BELAY ◽

EYASU MAKONNEN

Keyword(s):

Chronic Inflammation ◽

Aqueous Suspension ◽

Inflammatory Activity ◽

Maximum Effect ◽

Phytochemical Analysis ◽

Paw Edema ◽

Active Fraction ◽

Inflammatory Models ◽

Cotton Pellet ◽

Anti Inflammatory

Abstract. Belay R, Makonnen E. 2018. Anti-inflammatory activities of ethanol leaves extract and solvent fractions of Zehneria scabra (Cucurbitaceae) in rodents. Biofarmasi J Nat Prod Biochem 18: 42-56. Zehneria scarba (L.f.) Sond is one of the medicinal plants used in folkloric medicine of Ethiopia for years to treat various inflammatory disorders. The present study was aimed to validate the anti-inflammatory activity of crude 70% ethanol leaves extract (70EE) against a sub-acute model and further evaluate the solvent fractions (AF, BF, and CF) in an acute (carrageenan-induced paw edema), sub-acute (formaldehyde induced arthritis) and chronic (cotton pellet induced granuloma) inflammatory models. The 70EE was first prepared by maceration, and the fractions were obtained by sequential partitioning with chloroform and n-butanol from the aqueous suspension of crude 70EE. The test groups, then, received 100, 200 and 400 mg/kg of the crude 70EE or the fractions (AF, BF, and CF) at the same dose levels, whereas positive controls received aspirin (200mg/kg) or dexamethasone (0.5mg/kg) and negative controls received vehicle (2% tween 80 or distilled water, 10 mL/kg). All tested doses of the crude 70EE showed significant inhibition of formaldehyde induced arthritis at the 10th day of treatment, on which the 400mg/kg dose showed the maximum anti-arthritic effect (%A = 60.5; p < 0.001). In the carrageenan-induced paw edema, all the three fractions showed a statistically significant effect, in fact, with different onset and magnitude. In this model, the AF was found to be the most active fraction, and the 400mg/kg dose demonstrated the maximum effect (%A = 76.25; p < 0.001) at 5h post-induction, which is much better than the effect of aspirin at the dose employed. The overall order of efficacy in inhibiting the exudative component of carrageenan-induced paw edema was found to be AF> BF> CF. The AF was also found to be the most active fraction in inhibiting the exudative component of chronic inflammation in the cotton pellet induced granuloma model, where the maximum effect (%A = 43.10, p < 0.001) was exhibited by a dose of 400mg/kg. The AF was also the most active fraction in inhibiting formaldehyde induced arthritis, in which the BF and CF relatively showed a comparable effect throughout day 4-10. On the contrary, in the cotton pellet induced granuloma model, the CF was found to be the most active fraction in inhibiting the proliferative and granulomatous component of chronic inflammation, and the overall order of effectiveness was found to be CF> AF> BF. Besides, 400mg/kg of CF demonstrated the maximum inhibition of granuloma formation (%A = 55.52; P < 0.001). The phytochemical analysis revealed the differential distribution of secondary metabolites into the three fractions, which either singly or in concert appeared to be responsible for the observed effects. The data obtained from the present study collectively indicate that the extract and fractions of leaves of Z.scabra possessed a significant anti-inflammatory activity, upholding the folkloric use of the plant.

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Investigation of Active Anti-Inflammatory Constituents of Essential Oil from Pinus koraiensis (Sieb. et Zucc.) Wood in LPS-Stimulated RBL-2H3 Cells

Biomolecules ◽

10.3390/biom11060817 ◽

2021 ◽

Vol 11 (6) ◽

pp. 817

Author(s):

Ji-Yoon Yang ◽

Won-Sil Choi ◽

Ki-Joong Kim ◽

Chang-Deuk Eom ◽

Mi-Jin Park

Keyword(s):

Essential Oil ◽

Inflammatory Cytokines ◽

Positive Control ◽

Inflammatory Activity ◽

Pinus Koraiensis ◽

Korean Pine ◽

Inflammatory Conditions ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Pro Inflammatory Cytokines

In a previous study, we demonstrated the anti-inflammatory activity of the essential oil extracted from Korean pine (Pinus koraiensis, Sieb. et Zucc.) wood. This study aims to investigate the active anti-inflammatory constituents of P. koraiensis oil. The essential oil was extracted from P. koraiensis wood by hydrodistillation and was divided into six fractions (A–F) through fractional distillation. Then, the anti-inflammatory activities of the fractions (A–F) were determined. Fractions A and F markedly downregulated the production of pro-inflammatory cytokines as well as the secretion of β-hexosaminidase in lipopolysaccharide (LPS)-stimulated RBL-2H3 cells. The main constituents of the active anti-inflammatory A and F fractions were (+)-α-pinene, (−)-β-pinene, (+)-α-terpineol, 3-carene, (+)-limonene, and longifolene. These six single compounds decreased the expression of inflammatory-related genes (i.e., IL-4 and IL-13) as well as the secretion of β-hexosaminidase in LPS-stimulated RBL-2H3 cells. (+)-α-Pinene, (−)-β-pinene, (+)-α-terpineol, and longifolene exhibited the strongest effects; these effects were comparable to those of the positive control (i.e., dexamethasone). The findings indicate that the interactions between these components exhibit potential for the management and/or treatment of inflammatory conditions as well as base structures for the development of novel anti-inflammatory drugs.

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Anti-Edematogenic and Anti-Granuloma Activity of a Synthetic Curcuminoid Analog, 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one, in Mouse Models of Inflammation

Molecules ◽

10.3390/molecules24142614 ◽

2019 ◽

Vol 24 (14) ◽

pp. 2614 ◽

Cited By ~ 2

Author(s):

Nadia Hisamuddin ◽

Wan Mastura Shaik Mossadeq ◽

Mohd Roslan Sulaiman ◽

Faridah Abas ◽

Sze Wei Leong ◽

...

Keyword(s):

Mouse Models ◽

Curcuma Longa ◽

Biological Properties ◽

Inflammatory Activity ◽

Paw Edema ◽

Time Intervals ◽

Mediators Of Inflammation ◽

Cotton Pellet ◽

Anti Inflammatory ◽

Pharmacological Basis

Curcumin, derived from the rhizome Curcuma longa, has been scientifically proven to possess anti-inflammatory activity but is of limited clinical and veterinary use owing to its low bioavailability and poor solubility. Hence, analogs of curcuminoids with improved biological properties have been synthesized to overcome these limitations. This study aims to provide the pharmacological basis for the use of 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one (DHHPD), a synthetic curcuminoid analog, as an anti-edematogenic and anti-granuloma agent. The carrageenan-induced paw edema and the cotton pellet-induced granuloma assays were used to assess the anti-inflammatory activity of DHHPD in mice. The effects of DHHPD on the histaminergic, serotonergic, and bradykininergic systems were determined by the histamine-, serotonin-, and bradykinin-induced paw edema tests, respectively. DHHPD (0.1, 0.3, 1, and 3 mg/kg, intraperitoneal) evoked significant reductions (p < 0.05) in carrageenan-induced paw edema at different time intervals and granuloma formation (p < 0.0001) by 22.08, 32.57, 37.20, and 49.25%, respectively. Furthermore, DHHPD significantly reduced paw edema (p < 0.05) induced by histamine, serotonin, and bradykinin. The present study suggests that DHHPD exerts anti-edematogenic activity, possibly by inhibiting the synthesis or release of autacoid mediators of inflammation through the histaminergic, serotonergic, and bradykininergic systems. The anti-granuloma effect may be attributed to the suppression of transudative, exudative, and proliferative activities associated with inflammation.

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Aktifitas Kunyit (Curcuma domestica Val.) Sebagai Antiinflamasi Ditinjau Dari Berbagai Literatur

Edu Masda Journal ◽

10.52118/edumasda.v5i1.120 ◽

2021 ◽

Vol 5 (1) ◽

pp. 102

Author(s):

Humaira Fadhilah ◽

Karunia Rachmani ◽

Nurihardianti Hajaring

Keyword(s):

Side Effects ◽

Tissue Injury ◽

Inflammatory Activity ◽

Literature Study ◽

Induction Method ◽

Protective Response ◽

Physical Trauma ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Inflammatory Effect

Inflammation is a normal protective response to tissue injury caused by physical trauma, damaging chemicals, or microbiological substances. Steroids and nonsteroidal anti-inflammatory drugs have many side effects, so there are many anti-inflammatory developments originating from natural ingredients, especially in plants. Plants that are scientifically proven to have anti-inflammatory properties, namely turmeric (Curcuma domestica Val.) The method used in this literature study is a review of various journals published online, with the keyword turmeric as an anti-inflammatory, reviewed one by one and then the journals obtained are collected and information created by summarizing the content and then comparing the journals to be used as references. The results showed that turmeric tested had anti-inflammatory activity. The strength of the anti-inflammatory effect is shown by the carrageenan induction method which inhibits endema in rat feet and inflammation in the liver using the method of induction by diethylnitrosamine in this plant varies, depending on the dose. Compounds that are considered to provide anti-inflammatory activity are curcumin class compounds because they can inhibit the formation of prostagladin, thromboxan, and prostagycycline by inhibiting the activity of the cyclooxygenase enzyme. Curcumin also inhibits the formation of leuketrien compounds by inhibiting the activity of the lipoxygenase enzyme.Keywords: Anti-inflamatoryTurmericCucurminABSTRAK Inflamasi merupakan perlindungan normal ketika timbul luka jaringan karena zat mikrobiologi, zat kimia atau trauma fisik. Efek samping yang ditimbulkan oleh obat antiinflamasi banyak sehingga dibuat bahan alam untuk pengembangan antiinflamasi salah satunya adalah tanaman. Kunyit (Curcumma domestica Val.) adalah tanaman yang memiliki khasiat antiinflamasi yang terbukti secara ilmiah. Metode yang digunakan adalah studi literatur dengan kata kunci kunyit sebagai antiinflamasi, diulas satu persatu kemudian jurnal yang didapat dikumpulkan dan informasi dibuat dengan merangkum isi lalu membandingkan jurnal yang akan dijadikan acuan. Hasil membuktikan bahwa kunyit memiliki aktivitas antiinflamasi. Efek antiinflamasi ditunjukkan dengan metode induksi karagenan yg menghambat endema pada kaki tikus dan peradangan pada hati tikus menggunakan metode induksi oleh dietilnitrosamin tergantung dosisnya pada tanaman berbeda. Senyawa golongan kurkumin merupakan senyawa yang terbukti memberikan aktivitas antiinflamasi karena dapat menghambat pembentukan prostagladin, prostagsiklin dan tromboksan dengan cara menghambat aktifitas enzim siklooksigenase. Aktivitas yang lain dari kurkumin adalah menghambat pembentukan senyawa leuketrien dengan menghambat aktifitas enzim lipoxygenase.Kata Kunci: AntiinflamasiKunyitKukurmin

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Evaluation of anti-inflammatory activity of Jasminum sessiliflorum extracts

International Journal of Research in Pharmaceutical Sciences ◽

10.26452/ijrps.v10i3.1501 ◽

2019 ◽

Vol 10 (3) ◽

pp. 2515-2518

Author(s):

Ruby Philip ◽

Kathiresan Krishnasamy ◽

Elessy Abraham

Keyword(s):

Medicinal Plants ◽

Adverse Effects ◽

Ethyl Acetate ◽

Inflammatory Activity ◽

Paw Edema ◽

Reference Drug ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Dose Dependent ◽

Ethyl Acetate Extracts

Medicinal plants are important resources for the development of novel anti-inflammatory agents. Synthetic anti-inflammatory drugs have several adverse effects. Medicinal plants have numerous that are safer well as better substitutes for the prevention and management of various diseases and disorders. The and ethyl acetate extracts of Jasminum were evaluated for their potential as anti-inflammatory agents in by inducing paw edema in rats using . The anti-inflammatory activity of the reference drug was compared with the extracts of Jasminum . The extracts on screening indicated the presence of such as , , , alkaloids, and . The study established significant anti-inflammatory nature of the Jasminum extracts in a manner which is dose-dependent. The results indicate that both the extracts of Jasminum possess anti-inflammatory activity of significance and can be used in the development for novel anti-inflammatory moieties.

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