Differences between the effects of acute and long-term treatment with desmethylimipramine on reserpine-induced release of amines from rat brain

1975 ◽  
Vol 24 (13-14) ◽  
pp. 1321-1325 ◽  
Author(s):  
Suzanne Roffler-Tarlov
Keyword(s):  
Rat Brain ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Long-term treatment with fluoxetine induces desensitization of 5-HT4receptor-dependent signalling and functionality in rat brain

2009 ◽  
Vol 110 (3) ◽  
pp. 1120-1127 ◽  
Author(s):  
Rebeca Vidal ◽  
Elsa M. Valdizán ◽  
Ricardo Mostany ◽  
Angel Pazos ◽  
Elena Castro
Keyword(s):  
Rat Brain ◽  
Term Treatment ◽  
Long Term Treatment

Effects of long-term treatment with methyl mercury on the developing rat brain

1991 ◽  
Vol 56 (2) ◽  
pp. 158-169 ◽  
Author(s):  
Helena Lindström ◽  
Johan Luthman ◽  
Agneta Oskarsson ◽  
Johanna Sundberg ◽  
Lars Olson
Keyword(s):  
Rat Brain ◽  
Methyl Mercury ◽  
Term Treatment ◽  
Long Term Treatment ◽  
Developing Rat

scholarly journals Chlorpromazine affects the numbers of Sox-2, Musashi1 and DCX-expressing cells in the rat brain subventricular zone

2021 ◽  
Author(s):  
Jakub Skałbania ◽  
Artur Pałasz ◽  
Iwona Błaszczyk ◽  
Aleksandra Suszka-Świtek ◽  
Marek Krzystanek ◽  
...  
Keyword(s):  
Rat Brain ◽  
Adult Neurogenesis ◽  
Subventricular Zone ◽  
Cell Formation ◽  
Term Treatment ◽  
Endogenous Factors ◽  
Toxicological Studies ◽  
Long Term Treatment ◽  
Glial Cell Proliferation

Abstract Background Adult neurogenesis observed both in the subventricular zone (SVZ) and hippocampus may be regulated and modulated by several endogenous factors, xenobiotics and medications. Classical and atypical antipsychotic drugs are able to affect neuronal and glial cell proliferation in the rat brain. The main purpose of this structural study was to determine whether chronic chlorpromazine treatment affects adult neurogenesis in the canonical sites of the rat brain. At present, the clinical application of chlorpromazine is rather limited; however, it may still represent an important model in basic neuropharmacological and toxicological studies. Methods The number of neural progenitors and immature neurons was enumerated using immunofluorescent detection of Sox2, Musashi1 and doublecortin (DCX) expression within SVZ. Results Chlorpromazine has a depressive effect on the early phase of adult neurogenesis in the rat subventricular zone (SVZ), as the mean number of Sox-2 immunoexpressing cells decreased following treatment. Conclusion Collectively, these results may suggest that long-term treatment with chlorpromazine may decrease neurogenic stem/progenitor cell formation in the rat SVZ and may affect rostral migratory stream formation.

Effect of long-term treatment with escitalopram on spexin, nesfatin-1 and neuropeptide S mRNA expression in the rat brain

2016 ◽  
Vol 26 ◽  
pp. S216
Author(s):  
A. Palasz ◽  
A. Suszka-Świtek ◽  
K. Bogus ◽  
L. Filipczyk ◽  
E. Rojczyk ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Rat Brain ◽  
Term Treatment ◽  
Neuropeptide S ◽  
Long Term Treatment
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