Effect of long-term treatment with escitalopram on spexin, nesfatin-1 and neuropeptide S mRNA expression in the rat brain

2016 ◽  
Author(s):  
Artur Palasz
Keyword(s):  
Mrna Expression ◽  
Rat Brain ◽  
Term Treatment ◽  
Neuropeptide S ◽  
Long Term Treatment

Effect of long-term treatment with escitalopram on spexin, nesfatin-1 and neuropeptide S mRNA expression in the rat brain

2016 ◽  
Vol 26 ◽  
pp. S216
Author(s):  
A. Palasz ◽  
A. Suszka-Świtek ◽  
K. Bogus ◽  
L. Filipczyk ◽  
E. Rojczyk ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Rat Brain ◽  
Term Treatment ◽  
Neuropeptide S ◽  
Long Term Treatment

Long-term treatment with angiotensin II type 1 receptor antagonist, CV-11974, restores β-catenin mRNA expression in volume-overloaded rabbit hearts

2002 ◽  
Vol 17 (1) ◽  
pp. 36-41 ◽  
Author(s):  
Makoto Itoh ◽  
Y. Takeishi ◽  
Shigekazu Nakada ◽  
Takuya Miyamoto ◽  
Yuichi Tsunoda ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Receptor Antagonist ◽  
Mrna Expression ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain

2015 ◽  
Vol 28 (2) ◽  
pp. 110-116
Author(s):  
Artur Palasz ◽  
Ewa Rojczyk ◽  
Milosz Golyszny ◽  
Lukasz Filipczyk ◽  
John J. Worthington ◽  
...  
Keyword(s):  
Brain Structures ◽  
Term Treatment ◽  
Complex Nature ◽  
Mrna Levels ◽  
Neuropeptide S ◽  
Long Term Treatment ◽  
Rat Brainstem ◽  
Haloperidol Treatment ◽  
Potential Interactions

ObjectiveThe brainstem-derived neuropeptide S (NPS) has a multidirectional regulatory activity, especially as a potent anxiolytic factor. Accumulating data suggests that neuroleptics affect peptidergic signalling in various brain structures. However, there is no information regarding the influence of haloperidol on NPS and NPS receptor (NPSR) expression.MethodsWe assessed NPS and NPSR mRNA levels in brains of rats treated with haloperidol using quantitative real-time polymerase chain reaction.ResultsChronic haloperidol treatment (4 weeks) led to a striking upregulation of NPS and NPSR expression in the rat brainstem. Conversely, the NPSR mRNA expression was decreased in the hippocampus and striatum.ConclusionsThis stark increase of NPS in response to haloperidol treatment supports the hypothesis that this neuropeptide is involved in the dopamine-dependent anxiolytic actions of neuroleptics and possibly also in the pathophysiology of mental disorders. Furthermore, our findings underline the complex nature of potential interactions between dopamine receptors and brain peptidergic pathways, which has potential clinical applications.

scholarly journals Long-term treatment with fluoxetine induces desensitization of 5-HT4receptor-dependent signalling and functionality in rat brain

2009 ◽  
Vol 110 (3) ◽  
pp. 1120-1127 ◽  
Author(s):  
Rebeca Vidal ◽  
Elsa M. Valdizán ◽  
Ricardo Mostany ◽  
Angel Pazos ◽  
Elena Castro
Keyword(s):  
Rat Brain ◽  
Term Treatment ◽  
Long Term Treatment
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