The role of the subfornical organ in the drinking behavior of the pigeon

1986 ◽  
Vol 381 (2) ◽  
pp. 289-299 ◽  
Author(s):  
Maurizio Massi ◽  
Giuseppe De Caro ◽  
Luigi Mazzarella ◽  
Alan N. Epstein
Keyword(s):  
Drinking Behavior ◽  
Subfornical Organ

Alcohol use in daily life: Examining the role of trait and state impulsivity facets

2020 ◽  
Author(s):  
Sarah A Griffin ◽  
Timothy J Trull
Keyword(s):  
Alcohol Use ◽  
Sensation Seeking ◽  
Daily Life ◽  
Drinking Behavior ◽  
Cross Sectional ◽  
Trait Level ◽  
Trait Impulsivity ◽  
Drinking Behaviors ◽  
Ecological Momentary

Objectives: Using Ecological Momentary Assessment methods (EMA) we aimed to investigate the influence of trait and state (momentary) impulsivity on alcohol use behaviors in daily life. Facets of the UPPS trait model of impulsivity (Whiteside and Lynam, 2001) have been found to differentially relate to alcohol-related outcomes and behaviors in cross-sectional and longitudinal studies. The present work expands on this by assessing UPPS facets in daily life and examining the contributions of trait and state impulsivity facets to daily life drinking behavior. Methods: 49 participants were prompted at least six times per day for 21 days. A total of 4,548 collected EMA reports were included in analyses. Multi-level models were computed predicting daily life alcohol use behaviors from state and trait impulsivity facets and relevant covariates. Results: Individual facets of momentary impulsivity differentially related to alcohol outcomes, such that (lack of) premeditation and, to a lesser extent, sensation seeking showed unique patterns of association with drinking and drinking quantity. Only trait levels of (lack of) premeditation were related to drinking behavior in daily life; no other trait UPPS scale significantly related to alcohol use. Conclusions: These results highlight state difficulties with premeditation as particularly relevant to drinking behavior in daily life. Our results also support the incremental validity of state impulsivity facets over trait level measures in relation to drinking behavior in daily life. These findings offer important insight into the phenomenology of daily-life alcohol use and highlight possible avenues for intervention and prevention efforts. Public Health Statement: Momentary fluctuations in premeditation predict alcohol use in daily life. Treatments targeting planning or forethought in relation to alcohol use may interrupt this process contributing to daily life drinking behaviors.

Abstract P059: A A Role of Aminopeptidase A in the Brain on Cardiovascular Regulation of Conscious Rat

Hypertension ◽  
2015 ◽  
Vol 66 (suppl_1) ◽  
Author(s):  
Takuto Nakamura ◽  
Masanobu Yamazato ◽  
Akio Ishida ◽  
Yusuke Ohya
Keyword(s):  
Blood Pressure ◽  
Protein Expression ◽  
Drinking Behavior ◽  
Cardiovascular Regulation ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Aminopeptidase A ◽  
The Brain

Objective: Aminopeptidase A (APA) have important role in conversion of Ang II to Ang III. Intravenous APA administration lowers blood pressure in hypertensive rats. In contrast, APA inhibition in the brain lowers blood pressure in hypertensive rats. Therefore APA might have different role on cardiovascular regulation. However, a role of APA and Ang III on cardiovascular regulation especially in the brain has not been fully understood. Our purpose of present study was to investigate a role of APA and Ang III in the brain on cardiovascular regulation in conscious state. Method: 12-13 weeks old Wistar Kyoto rat (WKY) and 12-16 weeks old spontaneously hypertensive rat (SHR) were used. i) APA distribution in the brain was evaluated by immunohistochemistry. Protein expression of APA was evaluated by Western blotting. Enzymatic activity of APA was evaluated using L-glutamic acid γ-(4-nitroanilide) as a substrate. ii) WKY received icv administration of Ang II 25ng/2μL and Ang III 25ng/2μL. We recorded change in mean arterial pressure (MAP) in conscious and unrestraied state and measured induced drinking time. iii) SHR received icv administeration of recombinant APA 400ng/4μL. We recorded change in MAP in conscious and unrestraied state and measured induced drinking time. Result: i) APA was diffusely immunostained in the cells of brain stem including cardiovascular regulatory area such as rostral ventrolateral medulla. Protein expression and APA activity in the brain were similar between WKY (n=3) and SHR (n=3).ii) Icv administration of Ang II increased MAP by 33.8±3.8 mmHg and induced drinking behavior for 405±90 seconds (n=4). Icv administration of Ang III also increased MAP by 24.7±2.4 mmHg and induced drinking behavior for 258±62 seconds (n=3). These vasopressor activity and induced drinking behavior was completely blocked by pretretment of angiotensin receptor type 1 blocker.iii) Icv administration of APA increased MAP by 10.0±1.7 mmHg (n=3). Conclusion: These results suggested that Ang III in the brain increase blood pressure by Angiotensin type 1 receptor dependent mechanism and APA in the brain may involved in blood pressure regulation as a vasopressor enzyme.

scholarly journals Optogenetic approaches for the analysis of the role of dopaminergic neurotransmission in the development of alcohol dependence: from correlations to mechanisms

2019 ◽  
pp. 39-40
Author(s):  
E. A. Budygin
Keyword(s):  
Alcohol Drinking ◽  
Dopamine Release ◽  
Drinking Behavior ◽  
Brain Regions ◽  
Alcohol Addiction ◽  
Addictive Behaviors ◽  
Technological Advances ◽  
Dopaminergic Mechanisms ◽  
Neurochemical Changes

Despite many years of work on dopaminergic mechanisms of alcohol addiction, much of this evidence remains mostly correlative in nature. Fortunately, the latest technological advances have provided the opportunity to explore the causal role of neurochemical changes within brain regions involved in addictive behaviors. In this work using optogenetics, we have attempted to answer the question of how dopamine release dynamics control the motivational component of alcohol drinking behavior.

scholarly journals The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior

2015 ◽  
Vol 73 ◽  
pp. 15-22 ◽  
Author(s):  
Andreas Stengel ◽  
Hiroshi Karasawa ◽  
Yvette Taché
Keyword(s):  
Somatostatin Receptor ◽  
Drinking Behavior

Thirst

2020 ◽  
Author(s):  
Neil E. Rowland
Keyword(s):  
Environmental Variables ◽  
Body Fluid ◽  
Water Deprivation ◽  
Drinking Behavior ◽  
Fluid Loss ◽  
Incentive Salience ◽  
Motivated Behavior ◽  
Dry Food ◽  
Body Fluid Balance

Thirst is a specific and compelling sensation, often arising from internal signals of dehydration but modulated by many environmental variables. There are several historical landmarks in the study of thirst and drinking behavior. The basic physiology of body fluid balance is important, in particular the mechanisms that conserve fluid loss. The transduction of fluid deficits can be discussed in relation to osmotic pressure (osmoreceptors) and volume (baroreceptors). Other relevant issues include the neurobiological mechanisms by which these signals are transformed to intracellular and extracellular dehydration thirsts, respectively, including the prominent role of structures along the lamina terminalis. Other considerations are the integration of signals from natural dehydration conditions, including water deprivation, thermoregulatory fluid loss, and thirst associated with eating dry food. These mechanisms should also be considered within a broader theoretical framework of organization of motivated behavior based on incentive salience.

Subfornical organ: forebrain site of pressor and dipsogenic action of angiotensin II

1980 ◽  
Vol 239 (5) ◽  
pp. R382-R389 ◽  
Author(s):  
M. L. Mangiapane ◽  
J. B. Simpson
Keyword(s):  
Angiotensin Ii ◽  
Drinking Behavior ◽  
Subfornical Organ ◽  
Pressor Effect ◽  
Intracranial Injection ◽  
Physiological Range ◽  
A Site ◽  
Alternative Sites

Intracranial injection of angiotensin II (AII) at three brain sites elicited near simultaneous dipsogenic and pressor effects in rats. Both effects were maximal, occurred with the shortest latencies, and at the lowest doses of AII when the cannula terminated precisely within the parenchyma of the subfornical organ (SFO). Pressor effects were produced by SFO injection of a dose of AII (0.1 pg) which approximates plasma AII concentrations at the high end of the physiological range. Both the drinking and pressor effects were blocked by saralasin. Injections of AII at sites immediately adjacent to SFO produced smaller effects with longer latencies. These results ruled out the possibility that SFO injections were effective via leakage to alternative sites. The pressor effect of AII at the SFO remained in animals under chloralose anesthesia, demonstrating that it is not an artifact of drinking behavior. These results indicate that the SFO is a site of AII pressor action, and confirm previous demonstrations that the structure is a site of AII drinking action.

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