Therapeutic window of halothane anesthesia for reversal of delayed neuronal injury in gerbils: relationship to postischemic motor hyperactivity

1991 ◽  
Vol 563 (1-2) ◽  
pp. 33-38 ◽  
Author(s):  
Toshihiko Kuroiwa ◽  
Petra Bonnekoh ◽  
Konstantin-Alexander Hossmann
Keyword(s):  
Neuronal Injury ◽  
Therapeutic Window ◽  
Halothane Anesthesia ◽  
Motor Hyperactivity

Perfusion-Phase 18 F-PI-2620 Tau-PET Imaging as a Surrogate Marker of Neuronal Injury

2020 ◽  
Author(s):  
L Beyer ◽  
A Nitschmann ◽  
H Barthel ◽  
T van Eimeren ◽  
M Unterrainer ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Surrogate Marker ◽  
Neuronal Injury ◽  
Tau Pet ◽  
Tau Pet Imaging

Highly Potent rhenium(I) Tricarbonyl Complexes with Dual Anticancer and Anti-Angiogenic Activity Against Colorectal Carcinoma

2020 ◽  
Author(s):  
Joachim Delasoie ◽  
Aleksandar Pavic ◽  
Noémie Voutier ◽  
Sandra Vojnovic ◽  
Aurélien Crochet ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Anticancer Drugs ◽  
Xenograft Model ◽  
Therapeutic Window ◽  
Low Doses ◽  
Sunitinib Malate ◽  
Angiogenic Activity ◽  
Antimetastatic Activity ◽  
Clinical Drugs

Synthesized and characterized a series of rhenium(I) trycarbonyl-based complexes with increased lipophilicity. Two of these novel compounds were discovered to possess remarkable anticancer, anti-angiogenic and antimetastatic activity <i>in vivo</i> (zebrafish-human CRC xenograft model), being effective at very low doses (1-3 µM). At doses as high as 250 µM the complexes did not provoke toxicity issues encountered in clinical anticancer drugs (cardio-, hepato-, and myelotoxicity). The two compounds exceed the antiproliferative and anti-angiogenic potency of clinical drugs cisplatin and sunitinib-malate, and display a large therapeutic window.

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