A vasopressin presser receptor antagonist protects the rat gastric mucosa in the ethanol, reserpine, cold-restraint stress and indomethacin-indticed ulcer models

1990 ◽  
Vol 183 (2) ◽  
pp. 303-304
Author(s):  
F. László ◽  
E. Amani ◽  
S. Kaveh ◽  
J. Náfrádi ◽  
G. Karácsony ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Receptor Antagonist ◽  
Restraint Stress ◽  
Rat Gastric Mucosa ◽  
Cold Restraint Stress ◽  
Cold Restraint

Changes in endothelin-1 gene expression in the gastric mucosa of rats under cold-restraint-stress

2004 ◽  
Vol 5 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Yi Min Duan ◽  
Zhao Shen Li ◽  
Xian Bao Zhan ◽  
Guo Ming Xu ◽  
Zhen Xing Tu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Mucosa ◽  
Restraint Stress ◽  
Endothelin 1 ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals Anti-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury

2003 ◽  
Vol 285 (2) ◽  
pp. G414-G423 ◽  
Author(s):  
Claudia Bregonzio ◽  
Ines Armando ◽  
Hiromichi Ando ◽  
Miroslava Jezova ◽  
Gustavo Baiardi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Gastric Mucosa ◽  
Restraint Stress ◽  
Neutrophil Infiltration ◽  
Gastric Blood Flow ◽  
Gastric Injury ◽  
Tnf Α ◽  
Cold Restraint Stress ◽  
Cold Restraint

Stress reduces gastric blood flow and produces acute gastric mucosal lesions. We studied the role of angiotensin II in gastric blood flow and gastric ulceration during stress. Spontaneously hypertensive rats were pretreated for 14 days with the AT1 receptor antagonist candesartan before cold-restraint stress. AT1 receptors were localized in the endothelium of arteries in the gastric mucosa and in all gastric layers. AT1 blockade increased gastric blood flow by 40–50%, prevented gastric ulcer formation by 70–80% after cold-restraint stress, reduced the increase in adrenomedullary epinephrine and tyrosine hydroxylase mRNA without preventing the stress-induced increase in adrenal corticosterone, decreased the stress-induced expression of TNF-α and that of the adhesion protein ICAM-1 in arterial endothelium, decreased the neutrophil infiltration in the gastric mucosa, and decreased the gastric content of PGE2. AT1 receptor blockers prevent stress-induced ulcerations by a combination of gastric blood flow protection, decreased sympathoadrenal activation, and anti-inflammatory effects (with reduction in TNF-α and ICAM-1 expression leading to reduced neutrophil infiltration) while maintaining the protective glucocorticoid effects and PGE2 release. Angiotensin II has a crucial role, through stimulation of AT1 receptors, in the production and progression of stress-induced gastric injury, and AT1 receptor antagonists could be of therapeutic benefit.

scholarly journals Gastroprotective effects of nebivolol and simvastatin against cold restraint stress-induced gastric ulcer in rats

2020 ◽  
Vol 53 (3) ◽  
pp. 301-312
Author(s):  
Samaa Samir Kamar ◽  
Noha Samir Abdel Latif ◽  
Mohamed Fathi Mohamed Elrefai ◽  
Shaimaa Nasr Amin
Keyword(s):  
Gastric Ulcer ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals EFFECT OF SYNTHETIC ACYCLIC POLYISOPRENOIDS ON THE COLD-RESTRAINT STRESS INDUCED GASTRIC ULCER IN RATS

1983 ◽  
Vol 33 (3) ◽  
pp. 549-556
Author(s):  
Manabu MURAKAMI ◽  
Kiyoshi OKETANI ◽  
Hideaki FUJISAKI ◽  
Tsuneo WAKABAYASHI ◽  
Yuichi INAI ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Restraint Stress ◽  
Cold Restraint Stress ◽  
Cold Restraint

scholarly journals Chronic mild restraint protects the rat gastric mucosa from injury by ethanol or cold restraint

1983 ◽  
Vol 85 (2) ◽  
pp. 370-375 ◽  
Author(s):  
John L. Wallace ◽  
Norman S. Track ◽  
Max M. Cohen
Keyword(s):  
Gastric Mucosa ◽  
Rat Gastric Mucosa ◽  
Cold Restraint
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