Chronic haloperidol, but not clozapine, produces altered oral movements and increased extracellular glutamate in rats

1994 ◽  
Vol 263 (3) ◽  
pp. 269-276 ◽  
Author(s):  
Ronald E. See ◽  
Mary Ann Chapman
Keyword(s):  
Extracellular Glutamate ◽  
Oral Movements ◽  
Chronic Haloperidol

Regional homovanillic acid levels and oral movements in rats following chronic haloperidol treatment

1989 ◽  
Vol 98 (3) ◽  
pp. 430-431 ◽  
Author(s):  
Steven A. Kolenik ◽  
Frederick J. Hoffman ◽  
Malcolm B. Bowers
Keyword(s):  
Homovanillic Acid ◽  
Oral Movements ◽  
Chronic Haloperidol ◽  
Haloperidol Treatment

Oral Approach Avoidance

2019 ◽  
Vol 66 (5) ◽  
pp. 355-360 ◽  
Author(s):  
Sandra Godinho ◽  
Margarida V. Garrido ◽  
Oleksandr V. Horchak
Keyword(s):  
Native Speakers ◽  
Writing System ◽  
Oral Movements ◽  
Motivational States ◽  
Oral Approach ◽  
Approach Avoidance ◽  
Abstract Words ◽  
European Family

Abstract. Words whose articulation resembles ingestion movements are preferred to words mimicking expectoration movements. This so-called in-out effect, suggesting that the oral movements caused by consonantal articulation automatically activate concordant motivational states, was already replicated in languages belonging to Germanic (e.g., German and English) and Italic (e.g., Portuguese) branches of the Indo-European family. However, it remains unknown whether such preference extends to the Indo-European branches whose writing system is based on the Cyrillic rather than Latin alphabet (e.g., Ukrainian), or whether it occurs in languages not belonging to the Indo-European family (e.g., Turkish). We replicated the in-out effect in two high-powered experiments ( N = 274), with Ukrainian and Turkish native speakers, further supporting an embodied explanation for this intriguing preference.

The disturbance of nonverbal oral movements in patients with pure anarthria.

1988 ◽  
Vol 8 (3) ◽  
pp. 224-236 ◽  
Author(s):  
Kunihiko Endo ◽  
Hideo Makishita ◽  
Yoshio Tanizaki ◽  
Morihiro Sugishita ◽  
Nobuo Yanagisawa
Keyword(s):  
Oral Movements

scholarly journals Brain-Specific SNAP-25 Deletion Leads to Elevated Extracellular Glutamate Level and Schizophrenia-Like Behavior in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Hua Yang ◽  
Mengjie Zhang ◽  
Jiahao Shi ◽  
Yunhe Zhou ◽  
Zhipeng Wan ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Mouse Model ◽  
Glutamate Release ◽  
Critical Role ◽  
Conditional Knockout ◽  
Snare Complex ◽  
Extracellular Glutamate ◽  
Glutamate Level

Several studies have associated reduced expression of synaptosomal-associated protein of 25 kDa (SNAP-25) with schizophrenia, yet little is known about its role in the illness. In this paper, a forebrain glutamatergic neuron-specific SNAP-25 knockout mouse model was constructed and studied to explore the possible pathogenetic role of SNAP-25 in schizophrenia. We showed that SNAP-25 conditional knockout (cKO) mice exhibited typical schizophrenia-like phenotype. A significantly elevated extracellular glutamate level was detected in the cerebral cortex of the mouse model. Compared with Ctrls, SNAP-25 was dramatically reduced by about 60% both in cytoplasm and in membrane fractions of cerebral cortex of cKOs, while the other two core members of SNARE complex: Syntaxin-1 (increased ~80%) and Vamp2 (increased ~96%) were significantly increased in cell membrane part. Riluzole, a glutamate release inhibitor, significantly attenuated the locomotor hyperactivity deficits in cKO mice. Our findings provide in vivo functional evidence showing a critical role of SNAP-25 dysfunction on synaptic transmission, which contributes to the developmental of schizophrenia. It is suggested that a SNAP-25 cKO mouse, a valuable model for schizophrenia, could address questions regarding presynaptic alterations that contribute to the etiopathophysiology of SZ and help to consummate the pre- and postsynaptic glutamatergic pathogenesis of the illness.

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