Effect of workup strategy on the cost-effectiveness of fecal occult blood screening for colorectal cancer

1987 ◽  
Vol 93 (2) ◽  
pp. 301-310 ◽  
Author(s):  
Michael J. Barry ◽  
Albert G. Mulley ◽  
James M. Richter
Keyword(s):  
Colorectal Cancer ◽  
Cost Effectiveness ◽  
Occult Blood ◽  
Fecal Occult Blood ◽  
Fecal Occult ◽  
The Cost ◽  
Blood Screening

Cost-effectiveness analysis of fecal occult blood screening for colorectal cancer

2004 ◽  
Vol 20 (4) ◽  
pp. 434-439 ◽  
Author(s):  
Catherine Lejeune ◽  
Patrick Arveux ◽  
Vincent Dancourt ◽  
Sophie Béjean ◽  
Claire Bonithon-Kopp ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cost Effectiveness ◽  
Screening Test ◽  
Occult Blood ◽  
Sensitivity Analyses ◽  
Fecal Occult Blood ◽  
Decision Analysis Model ◽  
Economic Data ◽  
Fecal Occult ◽  
Blood Screening

Objectives: Clinical trials have demonstrated that fecal occult blood screening for colorectal cancer can significantly reduce mortality. However, to be deemed a priority from a public health policy perspective, any new program must prove itself to be cost-effective. The objective of this study was to assess the cost-effectiveness of screening for colorectal cancer using a fecal occult blood screening test, the Hemoccult-II, in a cohort of 100,000 asymptomatic individuals 50–74 years of age.Methods: A decision analysis model using a Markov approach simulates the trajectory of the cohort allocated either to screening or no screening over a 20-year period through several health states. Clinical and economic data used in the model came from the Burgundy trial, French population-based studies, and Registry data.Results: Modeling biennial screening versus the absence of screening over a 20-year period resulted in a 17.7 percent mortality reduction and a discounted incremental cost-effectiveness ratio of 3,357 € per life-year gained among individuals 50–74 years of age. Sensitivity analyses performed on epidemiological and economic data showed the strong impact on the results of colonoscopy cost, of compliance to screening, and of specificity of the screening test.Conclusions: Cost-effectiveness estimates and sensitivity analyses suggest that biennial screening for colorectal cancer with fecal occult blood test could be recommended from the age of 50 until 74. Our findings support the attempts to introduce large-scale population screening programs.

Cost-effectiveness modeling of colorectal cancer: Computed tomography colonography vs colonoscopy or fecal occult blood tests

2012 ◽  
Vol 81 (7) ◽  
pp. 1413-1419 ◽  
Author(s):  
Olivier Lucidarme ◽  
Mehdi Cadi ◽  
Genevieve Berger ◽  
Julien Taieb ◽  
Thierry Poynard ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Computed Tomography ◽  
Cost Effectiveness ◽  
Occult Blood ◽  
Fecal Occult Blood ◽  
Computed Tomography Colonography ◽  
Blood Tests ◽  
Fecal Occult

Fecal occult blood screening for colorectal cancer in a Veterans Administration hospital

1983 ◽  
Vol 145 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Stephen J. Sontag ◽  
Carol Durczak ◽  
Gerard V. Aranha ◽  
Gregorio Chejfec ◽  
William Frederick ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Occult Blood ◽  
Veterans Administration ◽  
Fecal Occult Blood ◽  
Fecal Occult ◽  
Administration Hospital ◽  
Blood Screening ◽  
Veterans Administration Hospital

Cost-effectiveness Analysis of Strategies for Colorectal Cancer Screening in Japan

1994 ◽  
Vol 10 (3) ◽  
pp. 359-375 ◽  
Author(s):  
Takuro Shimbo ◽  
Henry A. Glick ◽  
John M. Eisenberg
Keyword(s):  
Colorectal Cancer ◽  
Cost Effectiveness ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Blood Test ◽  
Fecal Occult Blood Test ◽  
Occult Blood ◽  
Fecal Occult Blood ◽  
Fecal Occult

AbstractTo determine the cost-effectiveness of colorectal cancer screening strategies in Japan and to determine the influence of long-term compliance with screening programs on the selection of strategies, the natural history of a simulated cohort of 40-year-old Japanese of both genders was modeled with and without colorectal cancer screening until age 75 years. Survival, number of complications, and direct medical costs were compared among several combinations of screening examinations. In addition, the age of initiating screening was varied, as was the long-term compliance rate. Strategies using immunoiogical fecal occult blood test were found to be the most cost-effective. Immunological fecal occult blood test followed by colonoscopy, if positive, would save 24.05 (5.88 discounted) days of life and cost 28,420 yen (US $210) per screened person, thus offering a cost-effectiveness ratio of 1.765 million yen (US $13,100) per year of life saved. If long-term compliance is 100%, initiating screening at age 40 years offers more years of life saved and a low incremental cost of screening. However, if more likely dropout rates are considered, initiation at age 40 years is dominated by later initiation of screening.

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