False-negative syphilis screening: The prozone phenomenon, nonimmune hydrops, and diagnosis of syphilis during pregnancy

1991 ◽  
Vol 35 (3) ◽  
pp. 290-290
Author(s):  
K Berkowitz ◽  
L Baxi ◽  
HE Fox
2020 ◽  
Vol 78 (3) ◽  
pp. 265-268
Author(s):  
Filipa Tavares Almeida ◽  
Filomena Azevedo ◽  
Carmen Lisboa

We report a case of early syphilis, presenting as balanitis and papular syphilides in an HIV-infected patient, with a previous history of syphilis infection, which demonstrated a false negative VDRL testing due to a prozone phenomenon. This false negative response results from overwhelming antibody titers, which interfere with the proper formation of the antigen-antibody lattice network, necessary to visualize a positive flocculation test.


Transfusion ◽  
2020 ◽  
Vol 60 (12) ◽  
pp. 3055-3059
Author(s):  
Rachel K. Horton ◽  
Micah D. Zuccarelli ◽  
Laurie L. Wakefield ◽  
Margaret A. DiGuardo ◽  
Manish J. Gandhi ◽  
...  

2016 ◽  
Vol 28 (7) ◽  
pp. 735-737 ◽  
Author(s):  
Alan R Katz ◽  
Alan Y Komeya ◽  
Juval E Tomas

We present a case report of a false-negative syphilis treponemal enzyme immunoassay test result in an HIV-infected male. While treponemal tests are widely considered to be more sensitive and specific than non-treponemal tests, our findings point to potential challenges using the reverse sequence syphilis screening algorithm.


1987 ◽  
Vol 147 (1) ◽  
pp. 42-42 ◽  
Author(s):  
Allison Imrie ◽  
Susan Best ◽  
Ronald Penny ◽  
David A. Cooper

1994 ◽  
Vol 21 (5) ◽  
pp. 243-246 ◽  
Author(s):  
MOHAMAD M. EL-ZAATARI ◽  
MARK G. MARTENS

2019 ◽  
Vol 9 (3) ◽  
pp. 341-343
Author(s):  
Luciane Moraes ◽  
Mara d’Almeida ◽  
Mayra Conde

Sign in / Sign up

Export Citation Format

Share Document