scholarly journals Syphilitic Balanitis of Follmann: Laboratory Pitfalls

2020 ◽  
Vol 78 (3) ◽  
pp. 265-268
Author(s):  
Filipa Tavares Almeida ◽  
Filomena Azevedo ◽  
Carmen Lisboa
Keyword(s):  
Infected Patient ◽  
False Negative ◽  
Previous History ◽  
Syphilis Infection ◽  
Flocculation Test ◽  
History Of ◽  
Antibody Titers ◽  
Lattice Network ◽  
Antigen Antibody ◽  
Prozone Phenomenon

We report a case of early syphilis, presenting as balanitis and papular syphilides in an HIV-infected patient, with a previous history of syphilis infection, which demonstrated a false negative VDRL testing due to a prozone phenomenon. This false negative response results from overwhelming antibody titers, which interfere with the proper formation of the antigen-antibody lattice network, necessary to visualize a positive flocculation test.

Case report and evaluation of the frequency of the prozone phenomenon in syphilis serology - an infrequent but important laboratory phenomenon

Sexual Health ◽  
2012 ◽  
Vol 9 (5) ◽  
pp. 488 ◽  
Author(s):  
Jeffrey J. Post ◽  
Candice Khor ◽  
Virginia Furner ◽  
Don E. Smith ◽  
L. Ross Whybin ◽  
...  
Keyword(s):  
Previous History ◽  
Treponema Pallidum ◽  
Delayed Diagnosis ◽  
Secondary Syphilis ◽  
Serum Samples ◽  
Syphilis Infection ◽  
Reactive Sample ◽  
Assay Result ◽  
History Of ◽  
Prozone Phenomenon

Background Treponema pallidum specific serology generally remains reactive for life. Therefore, the diagnosis of syphilis reinfection relies on clinical assessment and nontreponemal (reagin) serologic testing. The prozone phenomenon can lead to a falsely nonreactive rapid plasma reagin (RPR) assay result. Methods: We report a case of secondary syphilis in a HIV infected patient with a previous history of syphilis infection, where a falsely nonreactive RPR assay was associated with a delayed diagnosis of reinfection and infectious syphilis. The prozone phenomenon was detected in several of the patient’s serum samples collected around this time. We subsequently undertook a prospective evaluation for the prozone phenomenon in 3222 consecutive sera, which were assayed using the RPR assay for clinical purposes over a 10-month period. Results: The overall rate of the prozone phenomenon was 2 out of 3222 samples (0.06%; 95% confidence interval (CI): 0.02–0.22%) and the rate per reactive sample was 2 out of 397 (0.5%; 95% CI: 0.14–1.81%). Conclusion: Clinicians should request RPR testing at dilutions of sera when syphilis is suspected clinically and the RPR assay is nonreactive.

scholarly journals SARS-CoV-2 Vaccine-Induced Antibody Response and Reinfection in Persons with Past Natural Infection

2021 ◽  
Author(s):  
Nitu Chauhan ◽  
Ajeet Singh Chahar ◽  
Prem Singh ◽  
Neel Sarovar Bhavesh ◽  
Ravi Tandon ◽  
...  
Keyword(s):  
Viral Vector ◽  
Natural Infection ◽  
Previous History ◽  
Adenovirus Vector ◽  
Prior History ◽  
Igg Antibody ◽  
Vector Vaccine ◽  
Women Subjects ◽  
History Of ◽  
Antibody Titers

Several studies have shown that subjects with a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection had significantly higher antibody titers than previously uninfected vaccinees after vaccination with mRNA vaccine. Yet no information is available for other vaccines. In the current observational cohort study, 105 health care workers who had received Covishield an Adeno associated viral vector-based DNA vaccine were enrolled at Sarojini Nadu Medical College Agra, India. The study included 40 (23 men and 17 women) subjects with a previous history of SARS-CoV-2 infection and 65 participants (39 men and 26 women) who were not infected previously. Both the groups received the adenovirus vector vaccine ChAdOx1-S recombinant vaccines (Covishield, Astra Zeneca). The levels of SARS-CoV-2-anti-spike-IgG-antibodies titer were measured using Electrochemiluminescence immunoassay on Roche platform as arbitrary units per milliliter (AU/ml). After 28 days of the second dose, subjects with no previous SARSCoV-2 infection showed a significantly lower level of circulating anti-spike-IgG-antibody titers compared to previously infected participants. After the second dose, we also observed a significant increase in SARS-CoV-2 infection in subjects with no prior history of SARS-CoV-2 infection compared to subjects with a previous history of natural infection. The most important observation of the study is a low percentage of infection in previously infected subjects. The finding of the study also indicates the presence of robust humoral memory response in previously infected patients.

Urinary NMP22 in the management of superficial bladder tumours after transurethral resection

1998 ◽  
Vol 65 (1) ◽  
pp. 74-76
Author(s):  
V. Serretta ◽  
P. Vasile ◽  
V. Falletta ◽  
A. Licata ◽  
S. Pomara ◽  
...  
Keyword(s):  
Transurethral Resection ◽  
Superficial Bladder Cancer ◽  
Transitional Cell ◽  
False Negative ◽  
Previous History ◽  
False Negative Rate ◽  
History Of ◽  
The Mean ◽  
Carcinoma Of The Bladder ◽  
Bladder Tumours

The aim of this study was to evaluate the clinical utility of the NMP22 test after transurethral resection of superficial transitional cell carcinoma of the bladder. The test was performed in 28 patients with histologically confirmed bladder tumours and in 41 patients who already had two consecutive negative cytological and cystoscopic results at least 3 months after TUR. In the first group the mean NMP22 value was 62.5 u/ml with a false negative rate of 18%. The specificity of the NMP22 test in 41 patients with a previous history of TCCB was 49%. No difference was detected between patients treated or not with intravesical chemotherapy. Despite its good sensitivity, the NMP22 test cannot be adopted as a routine tool in post-TUR surveillance of patients with superficial bladder cancer, due to its low specificity.

scholarly journals Longitudinal observation of antibody responses after SARS-CoV-2 infection at 14 months

2021 ◽  
Author(s):  
Asiya kamber Zaidi ◽  
Puya Dehgani-Mobaraki ◽  
Nidhi Yadav ◽  
Alessandro Floridi
Keyword(s):  
Natural Infection ◽  
False Negative ◽  
Previous History ◽  
False Negative Rate ◽  
Severe Infection ◽  
Antibody Responses ◽  
Igg Antibody ◽  
Serological Tests ◽  
Significant Positive Association ◽  
Antibody Titers

Abstract A better understanding regarding antibody responses against SARS-CoV-2 after natural infection could provide valuable insights into the future implementation of vaccination policies. In this study, we aimed to assess the dynamics of IgG antibody titers in recovered COVID-19 patients over 14 months after mild and moderately severe infection using two FDA-approved immunoassays against SARS-CoV-2 Nucleocapsid protein (NCP)and anti-spike-receptor binding domain (S-RBD) through sequential serological tests at different time points. The demographics and clinical profile, that might be associated with the magnitude and longevity of antibody response were also analyzed. Our results suggest antibody persistency in 31 out of 32 (96.8%) subjects at 14 months post-infection. A significant positive association was observed between disease severity and anti-S-RBD IgG titers at 14 months. Patients who reported a loss of smell and taste during the clinical course of the disease also developed significantly better antibody titers. Patients who were seronegative for anti-NCP IgG (n=7) at 10 months, were found to be seropositive for anti-S-RBD IgG at 12,13 and 14 months emphasizing on higher false-negative rate for N protein-based antibody assays when compared with the anti-S-RBD assays. This study calls for prioritizing vaccination for “naive” individuals (with no previous history of COVID-19 infection) and recovered but antibody-negative individuals instead of “vaccination for all”. This strategy would be helpful in low-resource settings and areas experiencing vaccine shortages by saving time, effort, and assets that could be sourced for the vulnerable populations.

scholarly journals Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient

2019 ◽  
Vol 7 (12) ◽  
pp. 1987-1990
Author(s):  
AA Mas Putrawati Triningrat ◽  
Ni Made Wasiastiti Budi ◽  
IGAM Juliari ◽  
Ni Made Ayu Surasmiati ◽  
IGA Ratna Suryaningrum ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Infected Patient ◽  
Hand Movement ◽  
Clinical Manifestations ◽  
Signs And Symptoms ◽  
Penicillin G ◽  
Eye Drops ◽  
Syphilis Infection ◽  
Standard Regimen ◽  
History Of

BACKGROUND: In HIV-infected patient who accompanied by syphilis often difficult to diagnose and difficult to treat. The aim is to diagnostics understanding and to optimise the management and response therapy in patients with neuroretinitis syphilis in HIV-infected patients. CASE PRESENTATION: A 53-years old, bisexual, male patient whose initial presentation was a blurry vision on the left eye. History of a painless genital lesion, HIV infection (+) on ARV therapy. The visual acuity of hand movement (HM), RAPD (+), with vitreous opacities and optic disc swelling. The OCT RNFL showed neural layer thickening in all areas. VEP showed increased P100 latency, normal head and orbital CT scan. High VDRL and TPHA titer. Lumbar puncture examination showed non-reactive VDRL. Treated with topical prednisolone eye drops, oral neurotropic vitamin, and intramuscular injection of Benzathine Penicillin G. Diagnosed with OS neuroretinitis et causa syphilis infection, HIV stage II on HAART. Follow up in 2 months, the visual acuity improved, and serology post-therapy VDRL was decreased. CONCLUSION: High accuracy is needed for screening signs and symptoms in syphilis patients because of the varied clinical manifestations. Ocular syphilis manifestation in HIV has a higher risk for neurologic complications and the risk of failing treatment with the standard regimen.

405: Previous History of Bladder Cancer is an Independent Prognostic Factor for Upper Tract Transitional Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 135-135
Author(s):  
Eiji Kikuchi ◽  
Akira Miyajima ◽  
Ken Nakagawa ◽  
Mototsugu Oya ◽  
Takashi Ohigashi ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Prognostic Factor ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Previous History ◽  
Independent Prognostic Factor ◽  
Upper Tract ◽  
History Of

Popliteal artery thrombosis secondary to a tibial osteochondroma

VASA ◽  
2011 ◽  
Vol 40 (3) ◽  
pp. 251-255 ◽  
Author(s):  
Gruber-Szydlo ◽  
Poreba ◽  
Belowska-Bien ◽  
Derkacz ◽  
Badowski ◽  
...  
Keyword(s):  
Case Report ◽  
Magnetic Resonance Angiography ◽  
Popliteal Artery ◽  
Doppler Ultrasonography ◽  
Histopathological Examination ◽  
Previous History ◽  
Plain Radiography ◽  
Artery Thrombosis ◽  
History Of ◽  
The Right

Popliteal artery thrombosis may present as a complication of an osteochondroma located in the vicinity of the knee joint. This is a case report of a 26-year-old man with symptoms of the right lower extremity ischaemia without a previous history of vascular disease or trauma. Plain radiography, magnetic resonance angiography and Doppler ultrasonography documented the presence of an osteochondrous structure of the proximal tibial metaphysis, which displaced and compressed the popliteal artery, causing its occlusion due to intraluminal thrombosis..The patient was operated and histopathological examination confirmed the diagnosis of osteochondroma.

Rhabdomyolysis in DOMS

1999 ◽  
Vol 38 (05) ◽  
pp. 164-168 ◽  
Author(s):  
Gloria Ruiz Hernandez ◽  
C. Sanchez Marchori ◽  
J. Munoz Moliner ◽  
C. Martinez Carsi
Keyword(s):  
Bone Scintigraphy ◽  
Previous History ◽  
Biochemical Studies ◽  
History Of ◽  
Increased Activity

SummaryA 26-year-old man with a previous history of external twin bursitis was remitted to our Department for a bone scintigraphy. Before the study, the patient performed an elevated number of intense sprints. Bone scintigraphy showed a bilaterally increased activity in both anterior rectum muscles suggesting rhabdomyolysis. Biochemical studies and MRT confirmed the diagnosis.

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