Analysis of the petroleum components benzene, toluene, ethyl benzene and the xylenes in water by commercially available solid-phase microextraction and carbon-layer open tubular capillary column gas chromatography

1994 ◽  
Vol 677 (1) ◽  
pp. 201-205 ◽  
Author(s):  
Leonard P. Sarna ◽  
G.R. Barrie Webster ◽  
Marcia R. Friesen-Fischer ◽  
Ramanathan Sri Ranjan
Keyword(s):  
Gas Chromatography ◽  
Solid Phase Microextraction ◽  
Capillary Column ◽  
Solid Phase ◽  
Carbon Layer ◽  
Ethyl Benzene ◽  
Benzene Toluene ◽  
Capillary Column Gas Chromatography

scholarly journals Determination of Low-Level Residual Ethylene Oxide by Using Solid-Phase Microextraction and Gas Chromatography

2002 ◽  
Vol 85 (6) ◽  
pp. 1205-1209 ◽  
Author(s):  
Kamal Ayoub ◽  
Leonard Harris ◽  
Bill Thompson
Keyword(s):  
Gas Chromatography ◽  
Ethylene Oxide ◽  
Medical Devices ◽  
Solid Phase Microextraction ◽  
Capillary Column ◽  
Solid Phase ◽  
Extraction Temperature ◽  
Absorption Time ◽  
Low Level

Abstract Current methods of analysis for ethylene oxide (EO) in medical devices include headspace and simulated-use extractions followed by gas chromatography with either a packed or a capillary column. The quantitation limits are about 0.5–1.0 μg/g for a packed column and about 0.1–0.2 μg/g for a capillary column. The current allowable levels of EO on medical devices sterilized with EO gas as outlined in International Organization for Standardization (ISO) 10993-7 may be significantly reduced from current levels by applying the ISO Draft International Standard 10993-17 method for establishing allowable limits. This may require EO test methods with detection and quantitation limits that are much lower than those of the currently available methods. This paper describes a new method that was developed for the determination of low-level EO by solid-phase microextraction using the direct-immersion method. Factors such as temperature and stirring were found to affect absorption efficiency and absorption time. A low extraction temperature (about 6°C) was found to be more efficient than room-temperature extraction. Stirring was found to reduce absorption time by about 50%. Under these conditions, detection and quantitation limits of 0.002 and 0.009 μg/g, respectively, were obtained by using a capillary column. As a result, this method makes compliance with lower EO limits feasible.

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