The international standard for macrophage colony stimulating factor (M-CSF) Evaluation in an international collaborative study

1995 ◽  
Vol 179 (2) ◽  
pp. 141-151 ◽  
Author(s):  
Anthony R Mire-Sluis ◽  
Rose Gaines Das ◽  
Robin Thorpe
Keyword(s):  
Collaborative Study ◽  
Colony Stimulating Factor ◽  
International Standard ◽  
Macrophage Colony Stimulating Factor ◽  
International Collaborative ◽  
Macrophage Colony ◽  
Stimulating Factor ◽  
International Collaborative Study

A Collaborative Study Designed to Establish the 4th International Standard for Heparin

1984 ◽  
Vol 52 (02) ◽  
pp. 148-153 ◽  
Author(s):  
D P Thomas ◽  
A D Curtis ◽  
T W Barrowcliffe
Keyword(s):  
Collaborative Study ◽  
International Standard ◽  
Thrombin Inhibition ◽  
Freeze Dried ◽  
Assay Methods ◽  
The Mean ◽  
International Collaborative ◽  
International Collaborative Study

SummaryAn international collaborative study, in which 22 laboratories participated, was carried out to establish a replacement for the International Standard for Heparin. A total of 248 assays were analyzed, including APTT, thrombin inhibition and anti-Xa assays, as well as pharmacopoeial assays. Overall, there was less than 5% difference in the mean potency estimates of the candidate preparations, by all assay methods. The freeze-dried preparation 82/502 demonstrated the closest parallelism by bioassay to the existing standard and was established by WHO as the 4th International Standard for Heparin, with an assigned unitage of 1780 i.u. per ampoule.

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