[218b] l-Amino acid oxidase (snake venom)

1971 ◽  
pp. 597-600 ◽  
Author(s):  
Daniel Wellner
Keyword(s):  
Amino Acid ◽  
Snake Venom ◽  
Acid Oxidase ◽  
Amino Acid Oxidase

Impairment of Platelet Aggregation by Echis colorata Venom Mediated by L-Amino Acid Oxidase or H2O2

1982 ◽  
Vol 48 (03) ◽  
pp. 277-282 ◽  
Author(s):  
I Nathan ◽  
A Dvilansky ◽  
T Yirmiyahu ◽  
M Aharon ◽  
A Livne
Keyword(s):  
Hydrogen Peroxide ◽  
Amino Acid ◽  
Platelet Aggregation ◽  
Snake Venom ◽  
Oxidase Activity ◽  
Enzyme Preparation ◽  
Acid Oxidase ◽  
Crude Venom ◽  
Amino Acid Oxidase ◽  
Hemostatic Disorders

SummaryEchis colorata bites cause impairment of platelet aggregation and hemostatic disorders. The mechanism by which the snake venom inhibits platelet aggregation was studied. Upon fractionation, aggregation impairment activity and L-amino acid oxidase activity were similarly separated from the crude venom, unlike other venom enzymes. Preparations of L-amino acid oxidase from E.colorata and from Crotalus adamanteus replaced effectively the crude E.colorata venom in impairment of platelet aggregation. Furthermore, different treatments known to inhibit L-amino acid oxidase reduced in parallel the oxidase activity and the impairment potency of both the venom and the enzyme preparation. H2O2 mimicked characteristically the impairment effects of L-amino acid oxidase and the venom. Catalase completely abolished the impairment effects of the enzyme and the venom. It is concluded that hydrogen peroxide formed by the venom L-amino acid oxidase plays a role in affecting platelet aggregation and thus could contribute to the extended bleeding typical to persons bitten by E.colorata.

Insights into the structure, function and stability of bordonein-L, the first L-amino acid oxidase from Crotalus durissus terrificus snake venom

Biochimie ◽  
2019 ◽  
Vol 163 ◽  
pp. 33-49 ◽  
Author(s):  
Gisele A. Wiezel ◽  
Joane K. Rustiguel ◽  
David Morgenstern ◽  
Karina F. Zoccal ◽  
Lucia H. Faccioli ◽  
...  
Keyword(s):  
Amino Acid ◽  
Structure Function ◽  
Snake Venom ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Crotalus Durissus Terrificus ◽  
Crotalus Durissus

scholarly journals Isolation and biochemical, functional and structural characterization of a novel l-amino acid oxidase from Lachesis muta snake venom

Toxicon ◽  
2012 ◽  
Vol 60 (7) ◽  
pp. 1263-1276 ◽  
Author(s):  
Cristiane Bregge-Silva ◽  
Maria Cristina Nonato ◽  
Sérgio de Albuquerque ◽  
Paulo Lee Ho ◽  
Inácio L.M. Junqueira de Azevedo ◽  
...  
Keyword(s):  
Amino Acid ◽  
Snake Venom ◽  
Structural Characterization ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Lachesis Muta
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