Determination of a “critical shear stress level” applied to adherent mammalian cells

1992 ◽  
Vol 14 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Andreas Ludwig ◽  
Gerlinde Kretzmer ◽  
Karl Schügerl
ASAIO Journal ◽  
2018 ◽  
Vol 64 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Choon-Sik Jhun ◽  
Megan A. Stauffer ◽  
John D. Reibson ◽  
Eric E. Yeager ◽  
Raymond K. Newswanger ◽  
...  

Polymers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 2542
Author(s):  
Junxiu Lv ◽  
Xiaoyuan Zhang

This study mainly investigates the prediction models of shear parameters and dynamic creep instability for asphalt mixture under different high temperatures to reveal the instability mechanism of the rutting for asphalt pavement. Cohesive force c and internal friction angle φ in the shear strength parameters for asphalt mixture were obtained by the triaxial compressive strength test. Then, through analyzing the influence of different temperatures on parameters c and φ, the prediction models of shear strength parameters related to temperature were developed. Meanwhile, the corresponding forecast model related to confining pressure and shear strength parameters was obtained by simplifying the calculation method of shear stress level on the failure surface under cyclic loading. Thus, the relationship of shear stress level with temperature was established. Furthermore, the cyclic time FN of dynamic creep instability at 60 °C was obtained by the triaxial dynamic creep test, and the effects of confining pressure and shear stress level were considered. Results showed that FN decreases exponentially with the increase in stress levels under the same confining pressure and increases with the increase in confining pressure. The ratio between shear stress level and corresponding shear strength under the same confining pressure was introduced; thus, the relationship curve of FN with shear stress level can eliminate the effect of different confining pressures. The instability prediction model of FN for asphalt mixture was established using exponential model fitting analysis, and the rationality of the model was verified. Finally, the change rule of the parameters in the instability prediction model was investigated by further changing the temperature, and the instability forecast model in the range of high temperature for the same gradation mixture was established by the interpolation calculation.


2017 ◽  
Vol 143 (10) ◽  
pp. 04017045 ◽  
Author(s):  
Hicham (Sam) Salem ◽  
Colin D. Rennie

2015 ◽  
Vol 52 (1) ◽  
pp. 114-119 ◽  
Author(s):  
Jaromír Říha ◽  
Jan Jandora

The hole erosion test (HET) is used in the study of soil erosion in the case of what is known as “piping” when concentrated leaks occur. The HET enables the determination of soil erosion characteristics such as the critical shear stress along the pre-formed hole (pipe) and the coefficient of soil erosion. Normally, in the HET, the hydraulic gradient is determined from the difference between the piezometric heads measured at the inflow and outflow chambers (upstream and downstream of the soil specimen). Hydraulic analysis shows that such measurements ignore losses at the entrance and exit of the hole, causing the overestimation of the hydraulic gradient along the length of the hole, and thus the calculated shear stress. In this technical note, the results of preliminary analysis using the Bernoulli principle and of numerical study of the pressure conditions in the HET apparatus are shown. The turbulent flow in the HET apparatus was calculated using ANSYS commercial CFD (computational fluid dynamics) software. The analysis was performed for various hole entrance shapes. The conclusion of this note details the differences between traditionally determined hydraulic gradients and those numerically derived along the length of a hole.


2021 ◽  
Vol 9 ◽  
Author(s):  
Amy Engelbrecht-Wiggans ◽  
Stuart Leigh Phoenix

Stress rupture (sometimes called creep-rupture) is a time-dependent failure mode occurring in unidirectional fiber composites under high tensile loads sustained over long times (e. g., many years), resulting in highly variable lifetimes and where failure has catastrophic consequences. Stress-rupture is of particular concern in such structures as composite overwrapped pressure vessels (COPVs), tension members in infrastructure applications (suspended roofs, post-tensioned bridge cables) and high angular velocity rotors (e.g., flywheels, centrifuges, and propellers). At the micromechanical level, stress rupture begins with the failure of some individual fibers at random flaws, followed by local load-transfer to neighboring intact fibers through shear stresses in the matrix. Over time, the matrix between the fibers creeps in shear, which causes lengthening of local fiber overload zones around previous fiber breaks, resulting in even more fiber breaks, and eventually, formation clusters of fiber breaks of various sizes, one of which eventually grows to a catastrophically unstable size. Most previous models are direct extension of classic stochastic breakdown models for a single fiber, and do not reflect the micromechanical detail, particularly in terms of the creep behavior of the matrix. These models may be adequate for interpreting experimental, composite stress rupture data under a constant load in service; however, they are of highly questionable accuracy under more complex loading profiles, especially ones that initially include a brief “proof test” at a “proof load” of up to 1.5 times the chosen service load. Such models typically predict an improved reliability for proof-test survivors that is higher than the reliability without such a proof test. In our previous work relevant to carbon fiber/epoxy composite structures we showed that damage occurs in the form of a large number of fiber breaks that would not otherwise occur, and in many important circumstances the net effect is reduced reliability over time, if the proof stress is too high. The current paper continues our previous work by revising the model for matrix creep to include non-linear creep whereby power-law creep behavior occurs not only in time but also in shear stress level and with differing exponents. This model, thus, admits two additional parameters, one determining the sensitivity of shear creep rate to shear stress level, and another that acts as a threshold shear stress level reminiscent of a yield stress in the plastic limit, which the model also admits. The new model predicts very similar behavior to that seen in the previous model under linear viscoelastic behavior of the matrix, except that it allows for a threshold shear stress. This threshold allows consideration of behavior under near plastic matrix yielding or even matrix shear failure, the consequence of which is a large increase in the length-scale of load transfer around fiber breaks, and thus, a significant reduction in composite strength and increase in variability. Derivations of length-scales resulting from non-linear matrix creep are provided as Appendices in the Supplementary Material.


Sign in / Sign up

Export Citation Format

Share Document