A Xenopus lymphoid tumor cell line with complete Ig genes rearrangements and T-cell characteristics

1995 ◽  
Vol 32 (8) ◽  
pp. 583-593 ◽  
Author(s):  
Louis Du Pasquier ◽  
Michèle Courtet ◽  
Jacques Robert
Keyword(s):  
T Cell ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Lymphoid Tumor

Virus-specific transcription in a Herpesvirus saimiri-transformed lymphoid tumor cell line.

1983 ◽  
Vol 48 (2) ◽  
pp. 377-383 ◽  
Author(s):  
E Knust ◽  
W Dietrich ◽  
B Fleckenstein ◽  
W Bodemer
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Herpesvirus Saimiri ◽  
Lymphoid Tumor

scholarly journals Interleukin 7 induces CD4+ T cell-dependent tumor rejection.

1991 ◽  
Vol 174 (6) ◽  
pp. 1291-1298 ◽  
Author(s):  
H Hock ◽  
M Dorsch ◽  
T Diamantstein ◽  
T Blankenstein
Keyword(s):  
T Cell ◽  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Tumor Rejection ◽  
T Cell Subsets ◽  
Cd4 Cells ◽  
Antitumor Response ◽  
Interleukin 7

The potential of interleukin 7 (IL-7) to induce an antitumor response in vivo was analyzed. Therefore, the IL-7 gene was expressed in the plasmacytoma cell line J558L. Although the growth of IL-7-producing cells was not retarded in vitro, the IL-7-producing cells were completely rejected upon injection into mice. Tumor rejection was observed only in syngeneic but not in nude mice. The tumor-suppressive effect could be abolished by the parallel injection of an anti-IL-7 monoclonal antibody. Immunohistochemical analysis revealed IL-7-dependent infiltration of the tumor tissue by CD4+ and CD8+ T lymphocytes, and also type 3 complement receptor-positive (CR3+) cells, predominantly macrophages. Depletion of T cell subsets in tumor-bearing mice showed the absolute dependence of the antitumor response on CD4+ cells, whereas tumor rejection was unaffected by depletion of CD8+ cells. In addition to CD4+ cells, CR3+ cells were also needed for tumor rejection. The antitumor effect of IL-7 was confirmed by expression of the IL-7 gene in a second tumor cell line of different cellular origin. Together, our results demonstrate that a high local IL-7 concentration at the tumor site obtained by tumor cell-targeted gene transfer leads to tumor rejection involving a cellular mechanism that seems to be different from the ones observed in analogous experiments with other cytokines.

Differential effects of benzamidine derivatives on the expression of c-myc and HLA-DRα genes in a human B-lymphoid tumor cell line

1988 ◽  
Vol 38 (3) ◽  
pp. 297-305 ◽  
Author(s):  
Claudio Nastruzzi ◽  
Giordana Feriotto ◽  
Rafaella Barbieri ◽  
Roberto Ferroni ◽  
Mario Guarneri ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Tumor Cell Line ◽  
Lymphoid Tumor ◽  
Differential Effects ◽  
B Lymphoid

BIOCOMPATIBILITY STUDY OF α-Fe2O3 NANOPARTICLES PREPARED BY HYDROTHERMAL METHOD

2019 ◽  
Vol 26 (09) ◽  
pp. 1950058
Author(s):  
SADEQ H. LAFTA ◽  
ALI ABDULRAHMAN TAHA ◽  
MUHAMMAD M. FARHAN ◽  
SHAIMA Y. ABDULFATTAH
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Hydrothermal Method ◽  
Ferric Oxide ◽  
Tumor Cell Line ◽  
Oxide Nanoparticles ◽  
Average Particle ◽  
Normal Cells ◽  
Prepared Nanoparticles ◽  
Biocompatibility Study

Nanoparticles of alpha ferric oxide ([Formula: see text]-Fe2O3) were prepared by the hydrothermal method. Structural properties of [Formula: see text]-Fe2O3 were determined by XRD, SEM and AFM measurements. The particles had a good matching with standard pattern. Average particle size was about 90[Formula: see text]nm and the distribution extended from about 20[Formula: see text]nm to 120[Formula: see text]nm. Biocompatibility study of ferric oxide nanoparticles against bacteria, parasites, tumor cell line and normal cells was determined. No antibacterial activity was observed for the concentration, of ferric oxide nanoparticles in distilled water, up to 1.5[Formula: see text]mg/ml vs. E. coli and S. aureus. Moreover, MTT assay was used to determine the cytotoxicity against parasites and cells. Intermediate cytotoxicity (53.30%) of 1.5[Formula: see text]mg/ml of prepared nanoparticles was noted against L. tropica, while weak cytotoxicity of 5.20% was observed against L. donovani at the same concentration of ferric oxide nanoparticles. On the other hand, the prepared nanoparticles revealed low cytotoxicity (47.28%) against SR tumor cell line, while no cytotoxicity was shown against lymphocytes, as a model of normal cells.

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