Study of the diagnostic value of the dexamethasone suppression test in endogenous depression

1984 ◽  
Vol 6 (1) ◽  
pp. 33-42 ◽  
Author(s):  
M.Toscano Aguilar ◽  
M. Lemaire ◽  
P. Castro ◽  
M. Libotte ◽  
J. Reynders ◽  
...  
Keyword(s):  
Endogenous Depression ◽  
Diagnostic Value ◽  
Dexamethasone Suppression Test ◽  
Suppression Test ◽  
Dexamethasone Suppression

Ventricular size, the dexamethasone suppression test and outcome of severe endogenous depression following psychosurgery

1985 ◽  
Vol 72 (2) ◽  
pp. 166-171 ◽  
Author(s):  
H. M. A. S. Standish-Barry ◽  
A. S. Hale ◽  
A. Honig ◽  
N. Bouras ◽  
P. K. Bridges ◽  
...  
Keyword(s):  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Ventricular Size ◽  
Suppression Test ◽  
Dexamethasone Suppression

Dexamethasone suppression test and TRH test in endogenous depression

1983 ◽  
Vol 67 (4) ◽  
pp. 258-264 ◽  
Author(s):  
H. Aggernses ◽  
C. Kirkegaard ◽  
I. Krog-Meyer ◽  
B. Kijne ◽  
J. K. Larsen ◽  
...  
Keyword(s):  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Trh Test ◽  
Suppression Test ◽  
Dexamethasone Suppression

Clinical use of the DST in a Psychogeriatric Population

1984 ◽  
Vol 145 (4) ◽  
pp. 389-393 ◽  
Author(s):  
Ian G. McKeith
Keyword(s):  
Plasma Cortisol ◽  
Senile Dementia ◽  
The Elderly ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Clinical Implications ◽  
Clinical Use ◽  
Suppression Test ◽  
Confusional States ◽  
Dexamethasone Suppression

SummaryThe dexamethasone suppression test (DST) was administered to 95 patients referred to a psychogeriatric assessment service. Non-suppression of plasma cortisol was found in 28 out of 48 patients (58%) with senile dementia and all patients with arteriosclerotic dementia or acute confusional states. Non-suppression could not be explained by associated depressive symptoms. The DST was confirmed as a valid diagnostic test for endogenous depression in the elderly, but its value in distinguishing true dementing illnesses from depressive pseudodementia was not supported. The clinical implications of these findings for interpreting DST results in the elderly are discussed.

Dexamethasone Concentrations and the Dexamethasone Suppression Test in Psychiatric Disorders

1986 ◽  
Vol 148 (1) ◽  
pp. 66-69 ◽  
Author(s):  
Howard Morris ◽  
Vaughan Carr ◽  
Judy Gilliland ◽  
Michael Hooper
Keyword(s):  
Psychiatric Disorders ◽  
Clinical Diagnosis ◽  
Serum Cortisol ◽  
Endogenous Depression ◽  
Dexamethasone Suppression Test ◽  
Suppression Test ◽  
Cortisol Levels ◽  
High Concentrations ◽  
Dexamethasone Suppression ◽  
Low Serum

The dexamethasone suppression test (DST) has been widely used in psychiatry as a laboratory aid for the diagnosis of endogenous depression; failure to suppress serum cortisol levels is interpreted as confirming a clinical diagnosis of endogenous depression. We found that serum dexamethasone concentrations in this test vary widely and are determinants of the DST response: non-suppression of serum cortisol levels is associated with low serum dexamethasone concentrations, and suppression is associated with high concentrations.

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