The upregulation of Na+,K+-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate

1995 ◽  
Vol 34 (1) ◽  
pp. 33-39 ◽  
Author(s):  
I.J. Antia ◽  
C.E. Smith ◽  
A.J. Wood ◽  
J.K. Aronson
Keyword(s):  
Manic Depressive Psychosis ◽  
Manic Depressive

INHIBITION OF ALDOSTERONE PRODUCTION IN ADRENAL CELL SUSPENSIONS BY SERUM FROM PATIENTS WITH MANIC-DEPRESSIVE PSYCHOSIS

1979 ◽  
Vol 80 (1) ◽  
pp. 41-50 ◽  
Author(s):  
M. J. O'BRIEN ◽  
M. J. LEVELL ◽  
R. P. HULLIN
Keyword(s):  
Angiotensin Ii ◽  
Zona Glomerulosa ◽  
Serum Samples ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Aldosterone Production ◽  
Human Sera ◽  
Depressive Patients ◽  
Individual Human

A method of preparing a suspension of cells of the zona glomerulosa from rat adrenal capsules treated with crude collagenase is described. The cells responded to ACTH, angiotensin II and serotonin by increased production of aldosterone. Pooled human sera or individual human sera (from healthy normal or non-psychiatric in-patients) to a final concentration of 30% had no effect on ACTH-stimulated production of aldosterone. Many serum samples from five patients with manic-depressive psychosis, however, caused a reduction in aldosterone production; 65% of those samples taken during depression, 44% of the samples taken during manic episodes and 23% of the samples taken when the mood was normal. Sera from manic-depressive patients also reduced the production of aldosterone caused by angiotensin II or serotonin. This effect of serum from manic-depressives in vitro may be related to the abnormalities of aldosterone control in such patients.

Inhibition of In Vitro Production of Aldosterone by Manic-Depressive Sera

1981 ◽  
Vol 138 (5) ◽  
pp. 373-380 ◽  
Author(s):  
R. P. Hullin ◽  
M. J. Levell ◽  
M. J. O'Brien ◽  
K. J. Toumba
Keyword(s):  
Psychiatric Patients ◽  
In Vitro Production ◽  
Serum Samples ◽  
Cortical Cells ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Aldosterone Production ◽  
Significant Regression ◽  
Adrenal Cortical Cells

SummarySerum samples from psychiatric patients were added to incubations of rat adrenal cortical cells synthesizing aldosterone. A high proportion of sera from patients with bipolar manic-depressive psychosis inhibited aldosterone production, but chronic in-patients without affective disorders gave few inhibitory sera. Inhibition was greatest in depression, lowest during normal affect. In one patient studied through 11 affective cycles the inhibitor score increased during transitions from mania to depression, showing a significant regression on time. The possible relationship of this in vitro phenomenon to the defect of aldosterone regulation in manic-depressive psychosis is discussed.

Altered in vitro adaptive responses of lymphocyte Na+,K+-ATPase in patients with manic depressive psychosis

1991 ◽  
Vol 21 (3) ◽  
pp. 199-206 ◽  
Author(s):  
A.J. Wood ◽  
C.E. Smith ◽  
E.E. Clarke ◽  
P.J. Cowen ◽  
J.K. Aronson ◽  
...  
Keyword(s):  
Adaptive Responses ◽  
Manic Depressive Psychosis ◽  
Manic Depressive

Manic-Depressive Psychosis: An Alternative Conceptual Model

1968 ◽  
Vol 114 (517) ◽  
pp. 1523-1530 ◽  
Author(s):  
J.H. Court
Keyword(s):  
Conceptual Model ◽  
Human Behaviour ◽  
Biological Cycle ◽  
Traditional Concept ◽  
Manic Depressive Psychosis ◽  
Manic Depressive

The traditional concept of manic-depressive psychosis has been either a bi-polar or a circular one, used interchangeably. The psychoanalytic school has invoked the polarity of much of human behaviour as an appropriate analogy. For example “The tragedy is succeeded by the satyr play: after the serious worship of God comes the merry fair… On the same basis the same sequence is represented by the cycle of guilt feelings and unscrupulousness, later by the sequence of guilt feelings and forgiveness…. The manic-depressive cycle is a cycle between periods of increased and decreased guilt feelings: … this cycle, in the last analysis, goes back to the biological cycle of hunger and satiety in the infant” (Fenichel, 1946, p. 409).

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