THE RELATIONSHIP OF ANXIETY WITH HYPERTENSION FOR ELDERLY IN LAMPE WORKING AREA OF EAST RASANAE PUBLIC HEALTH CENTER BIMA

The increasing number of elderly people pays special attention to those who are experiencing an aging process. There are some problems that need special attention as the results of aging, such as physical, cognitive, emotional, social, and sexual changes. The purpose of this study is to find out the relationships between anxiety with hypertension of the elderly in subdistrict of Lampe working area of East Rasanae Public Health Center, Bima City.The research design of this study is cross sectional with correlation study approach. Around 23 elderly with hypertension was used as sample in the study. Sampling techniques used was total Sampling. The instrument used was questionnaires and spermank rank ws used for data analysis used.Based on the results of the questionnaire, 12 respondents showed no symptoms at all (52.2%), mild anxiety was amounted to 10 respondents (43.5%). 16 respondents (69.6%) were considered to have Hypertension at Stage I. This could also be seen from the test value analysis between anxiety and hypertension of the elderly where p value was greater than the significant level of 0.05 (p value>α) so that Ha was rejected and H0 was accepted, meaning that there was no relationship between anxiety and hypertension of the elderly in the subdistrict of Lampe working area of East Rasanae Public Health Center, Bima City.From the analysis, it can be concluded that there was no relationship between anxiety and hypertension of the elderly. Anxiety in the elderly is not a major factor that can trigger hypertension, yet there are other factors that should be considered by the elderly such as lifestyle and hereditary factors.

The biopsychosocial-spiritual factors influencing relapse of patients with schizophrenia

Objective: High relapse rate of patients with schizophrenia has a large impact on patients and their families that can be reviewed from biopsychosocial and spiritual factors. Determining all the potential risk factors of relapse in schizophrenia can help increase awareness of physicians, patients, and families. Physicians are the ones who examine patients and have responsibility to manage and educate them and expect to prevent relaps. This study analyze various biopsychosocial and spiritual factors affecting relapse occurrence in patients with schizophrenia. Methods: Cross sectional observational analytic study on 226 subjects with schizophrenia in three places in East Java, Indonesia, namely Soetomo Academic Hospital Surabaya (33.2%), Menur Hospital Surabaya (32.7%), and Radjiman Wediodiningrat Mental Hospital Lawang (34.1%) that met the inclusion and exclusion criteria. Data collection including 33 biopsychosocial and spiritual factors and were analyzed using bivariate and multivariate logistic regression. Results: Relapse rate within 1 year was 59.73%. There were 12 factors significantly affected the relapse of schizophrenia, namely history of physical disease of mothers during pregnancy ( p < .001; B = 27.31; 95% CI 3.96–188.52), presence of trigger ( p < .000; B = 6.25; 95% CI 2.61–14.96), negative beliefs ( p < .000; B = 4.94; 95% CI 2.10–11.61), hereditary factors ( p < .001; B = 4.84; 95% CI 1.93–12.10), insight ( p < .003; B = 4.27; 95% CI 1.62–11.27), 1-year GAF Scale ( p < .015; B = 3.79; 95% CI 1.30–11.09), response to treatment ( p < .006; B = 3.68; 95% CI 1.45–9.36), family knowledge ( p < .011; B = 3.23; 95% CI 1.31–7.93), history of head trauma ( p < .029; B = 3.13; 95% CI 1.13–8.69), medication side effects ( p < .028; B = 2.92; 95% CI 1.12–7.61), substance use history ( p < .031; B = 2.86; 95% CI 1.10–7.45), and occupation ( p < .040; B = 2.40; 95% CI 1.04–5.52). Conclusions: The 12 factors of biopsychosocial-spiritual are determinant to predict the risk of relapse in patients with schizophrenia. These factors should be emphasized in psychoeducation for patients and their families to enable intervention and relapse prevention.

Diet therapy in patients with metabolically associated fatty liver disease: what is the choice for particular patient?

Metabolically associated fatty liver disease is a widespread disease (MAFLD).The main treatment strategy for MAFLD is the correction of metabolic factors, changes in lifestyle, normalization of body weight, which is achieved by the use of diet therapy and physical activity.The purpose of this review is to present the characteristics of diets that have been studied in the treatment of patients with MAFLD.Results. The greatest evidence base on the effectiveness of treatment of MAFLD and the safety profile is the use of the Mediterranean diet and the diet with a low glycemic index. Patients should be advised to reduce their sugar intake, reduce their intake of saturated fatty acids and trans fats, and increase their intake of dietary fiber. Eating a balanced, calorie-restricted diet can help to provide healthy lifestyle and healthy eating habits, which are essential for the prevention and treatment of MAFLD. Hereditary factors, the composition of the intestinal microbiota, comorbid pathology can affect the results of diet therapy, which emphasizes the urgent need for an individualized approach in the treatment of this disease.

Somatotype as a Component of the Biological Determinant of Mental Health

The paper summarizes the results of the studies devoted to the impact of a person's constitutional features on his or her mental state. According to many anthropologists, human constitution is characterized not only by a specifics of metabolism level (muscle, fat and bone components of the body) and by a susceptibility to certain types of diseases, but also by psychophysiological features. Since biological health, including mental health, is generally determined by genetic and hereditary factors, the authors of the paper examine the possibility of considering the somatotype as a component of the biological determinant of mental health. To create the concept of a personalized approach that takes into account the relationship of somatotype and psychophysiological indicators in the educational process, the authors propose to conduct a study of the students' constitutional characteristics in combination with psychological testing.

ENDOSCOPIC TREATMENT OF HEREDITARY PANCREATITIS IN A CHILD WITH JUVENILE IDIOPATHIC ARTHRITIS: CLINICAL CASE REPORT AND LITERATURE REVIEW

The severe course of chronic pancreatitis (CP) in children is rare. More often it is caused by hereditary factors and abnormalities of the bile and pancreatic ducts. Cases of the development of pancreatitis against the background of systemic inflammatory diseases are described. Therapy of a systemic disease can aggravate the course of pancreatitis, and the general serious condition of the patient does not allow for the necessary surgical treatment. The article describes the clinical case report of a complicated course of CP against the background of juvenile idiopathic arthritis in a 17-year-old girl. The effectiveness of intraluminal endoscopic methods of treatment (wirsungotomy and stenting of the main pancreatic duct) for relieving exacerbation and complications of CP has been demonstrated.

Global Trends in Atherosclerosis Research in the Epigenetics Field: Bibliometric and Visualization Studies

Atherosclerosis is a pathological vascular state caused by the interaction of environmental and hereditary factors. Epigenetic modifications may be the bridge connecting environmental factors and genetic factors. A search for publications on the Web of Science database in the field of atherosclerosis related to epigenetics was conducted from the earliest mention to December 31, 2020. Data on total and annual publications, citations, impact factors, Hirsch (H)-index, citation times, most prolific authors, and frequently published journals were collected for quantitative and qualitative comparison. A total of 1848 publications related to epigenetics and atherosclerosis were found. The major contributing countries were the China (522, 28.23%), United States (485, 26.23%), and Germany (119, 6.44%). The greatest number of retrieved publications were published in the journal, “Arteriosclerosis, Thrombosis, and Vascular Biology” (62, 3.66%). The publication “Oxidative Stress and Diabetic Complications” was cited 2370 times. The most frequent keywords were “DNA methylation” and “LncRNA”. Publications on epigenetic research in the atherosclerosis field have increased significantly every year, indicating that the study of epigenetic modifications plays an increasingly important role in understanding the pathology of atherosclerosis.

Penyuluhan tentang Pemantauan Tumbuh Kembang dan Pemberian Vitamin A pada Balita di Posyandu Kenanga Desa Mampir Kec. Cileungsi Kabupaten Bogor Tahun 2021

The quality of a child can be judged from the process of growth and development. The process of growth and development is the result of the interaction of genetic factors and environmental factors. Genetic/hereditary factors are factors related to genes originating from the father and mother, while environmental factors include the biological, physical, psychological, and social environment. Growth and development have increased rapidly at an early age, from 0 to 5 years. This period is often referred to as the "Golden Age" phase. Vitamin A is one of the vitamins that functions for the development and performance of various organs of the body, such as the eyes, skin, reproductive organs, and the immune system. To prevent vitamin A deficiency in toddlers, the Ministry of Health of the Republic of Indonesia conducts a program of providing vitamin A through posyandu. Based on the various solutions to the activities mentioned above, the output targets to be achieved in this program are formulated, including scientific publications and increasing parental knowledge. Types of counseling with participatory methods in Monitoring Growth and Giving Vitamin A to Toddlers. The activity was carried out in July at the Posyandu Kenanga, Mampir Village, Kec. Cileungsi, Bogor Regency. The results of this series of community service activities and parents turned out to be quite satisfactory, both in terms of mastery of the material that had been given. Participants' understanding was seen during the discussion on growth and development and giving Vitamin A questions and answers. It can be concluded that the counseling went well, parents were enthusiastic about the number of participants who attended and hoped that this activity could continue

ABO Blood Groups and Risk of Glioma

Gliomas are one of the most common primary brain tumors and the etiology of gliomas remains unknown in most cases. The aim of this case–control study was to investigate possible association between incidence in relation to glioma and certain blood groups. This study included 100 histopathologically verified cases of glioma and 200 age and sex-matched controls without malignant diseases that were admitted to the same hospital. The results revealed that the patients with group AB were at 3.5-fold increased risk of developing glioma compared to the patients with other ABO blood groups. In this particular study, there was more male patients with glioma with the blood group AB. However, mechanisms that explain the relationship between the blood groups ABO and a cancer risk are unclear. Several hypotheses have been proposed, including the one with a modulatory role of blood group ABO antigens. In addition, the blood group ABO system regulates the level of circulating proinflammatory and adhesion molecules which play a significant role in the tumorigenesis process. Additionally, the recent discovery that includes the von Willebrand factor (vWF) as an important modulator of angiogenesis and apoptosis provides one plausible explanation as regards the role of the blood group ABO in the tumorigenesis process. To our knowledge, this is the first study that examined the relationship of blood group in patients diagnosed with glioma among the Serbian population. Moreover, for the first time our study results suggested that blood group AB increased the risk of glioma. The results of this study suggested that the blood group AB could be one of hereditary factors which had an influence on the occurrence of glioma. The further research is needed on a larger sample, to confirm these findings and the possible mechanisms by which the ABO system contributes to the pathology of glioma.

Clinical Genealogical and Epigenetic Examination of Patients with Juvenile Epiphysiolysis of the Femoral Head

Summary. Slipped capital femoral epiphysis (SCFE) is a multifactorial disease caused by a number of factors, and each of them can be triggered in its occurrence. Modern research is increasingly pointing to the leading role of epigenetic structures in the origin and course of this group of diseases. In recent years, the most promising area is the study of the role of microRNAs as an epigenetic factor that plays a leading role in the pathogenesis of multifactorial diseases. Objective: to develop a methodology for genetic genealogical examination of patients with juvenile epiphysiolysis of the femoral head. Materials and Methods. The study material was 26 patients with SCFE (15 girls and 11 boys) in different periods of sexual development: prepuberty – 7 patients, induction of puberty – 12 patients, and puberty and postpuberty – 7 patients. A questionnaire developed by us was used for clinical and genealogical research of the patients. The material for the epigenetic study, namely the study of microRNA-21 expression in patients with SCFE, was venous blood. Results. The expression of microRNA-21 in the blood of patients with SCFE is different (average expression is 0.86 conventional units) from those of healthy donors (average 0.393 conventional units) of the same age (p<0.05). Analysis of dependence on the period of sexual development revealed statistical differences in indicators depending on the group (p<0.05). No dependence of the level of microRNA-21 expression in patients with SCFE on sex and the period before or after surgery (p>0.05) was revealed. The obtained data on the probability of the influence of hereditary factors on the occurrence of SCFE are statistically significant (p<0.05). Conclusions. Our results of epigenetic and clinical genealogical research of patients with SCFE showed a high probability of influence of hereditary and epigenetic factors on the occurrence and course of this disease.

Relationship of microRNA locus with type 2 diabetes mellitus: a case-control study

Type 2 diabetes mellitus (T2DM) is considered as a metabolic disease with hyperglycemia. Accumulating investigations have explored the important role of hereditary factors for T2DM occurrence. Some functional microRNA (miR) polymorphisms may affect their interactions with target mRNAs and result in an aberrant expression. Thus, miR-variants might be considered as a biomarker of the susceptibility of T2DM. In this study, we recruited 502 T2DM cases and 782 healthy subjects. We selected miR-146a rs2910164 C>G, -196a2 rs11614913 T>C and -499 rs3746444 A>G loci and carried out an investigation to identify whether these miR- loci could influence T2DM occurrence. In this investigation, a Bonferroni correction was harnessed. After adjustment, we found that rs2910164 single nucleotide polymorphism (SNP) was a protective factor for T2DM (GG vs. CC/CG: adjusted P=0.010), especially in never drinking (GG vs. CC/CG: adjusted P=0.001) and ≥24 kg/m2 (GG vs. CC/CG: adjusted P=0.002) subgroups. We also identified that rs11614913 SNP was a protective factor for T2DM in smoking subjects (CC/TC vs. TT: adjusted P=0.002). When we analyzed an interaction of SNP-SNP with the susceptibility of T2DM. Rs11614913/rs3746444, Rs2910164/rs3746444, and rs11614913/rs2910164 combinations were not associated with the risk of T2DM. In summary, the present study highlights that rs2910164 SNP decreases a susceptibility of T2DM, especially in BMI ≥24 kg/m2 and never drinking subgroups. In addition, we also identify that rs11614913 C allele decreases the susceptibility of T2DM significantly in smoking subgroup.