Micronucleus test with mouse peripheral blood erythrocytes: summary report of the fifth collaborative study by CSGMT/JEMS.MMS

1991 ◽  
Vol 253 (3) ◽  
pp. 283
Keyword(s):  
Peripheral Blood ◽  
Micronucleus Test ◽  
Collaborative Study ◽  
Summary Report

Micronucleus test by flow cytometry: application to mouse peripheral blood

1988 ◽  
Vol 203 (5) ◽  
pp. 383
Author(s):  
H. Norppa ◽  
M. Hayashi ◽  
T. Sofuni ◽  
Y. Kodama ◽  
M. Ishidate
Keyword(s):  
Flow Cytometry ◽  
Peripheral Blood ◽  
Micronucleus Test

Effects of griseofulvin in medium-term liver carcinogenesis assay and peripheral blood micronucleus test in rat

2001 ◽  
Vol 21 (6) ◽  
pp. 441-451 ◽  
Author(s):  
Karine Labay ◽  
Mostafa Ould-Elhkim ◽  
Virginie Klés ◽  
Magali Guffroy ◽  
Jean-Michel Poul ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Micronucleus Test ◽  
Liver Carcinogenesis ◽  
Medium Term

scholarly journals Persistent Increased Frequency of Genomic Instability in Women Diagnosed with Breast Cancer: Before, during, and after Treatments

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Márcia Fernanda Correia Jardim Paz ◽  
André Luiz Pinho Sobral ◽  
Jaqueline Nascimento Picada ◽  
Ivana Grivicich ◽  
Antonio Luiz Gomes Júnior ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Comet Assay ◽  
Peripheral Blood ◽  
Micronucleus Test ◽  
Cancer Control ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Buccal Cells ◽  
Oncological Treatment

This study aimed to evaluate DNA damage in patients with breast cancer before treatment (background) and after chemotherapy (QT) and radiotherapy (RT) treatment using the Comet assay in peripheral blood and the micronucleus test in buccal cells. We also evaluated repair of DNA damage after the end of RT, as well as the response of patient’s cells before treatment with an oxidizing agent (H2O2; challenge assay). Fifty women with a mammographic diagnosis negative for cancer (control group) and 100 women with a diagnosis of breast cancer (followed up during the treatment) were involved in this study. The significant DNA damage was observed by increasing in the index and frequency of damage along with the increasing of the frequency of micronuclei in peripheral blood and cells of the buccal mucosa, respectively. Despite the variability of the responses of breast cancer patients, the individuals presented lesions on the DNA, detected by the Comet assay and micronucleus Test, from the diagnosis until the end of the oncological treatment and were more susceptible to oxidative stress. We can conclude that the damages were due to clastogenic and/or aneugenic effects related to the neoplasia itself and that they increased, especially after RT.

The micronucleus test of methyl methanesulfonate with mouse peripheral blood reticulocytes using acridine orange-coated slides

1992 ◽  
Vol 278 (2-3) ◽  
pp. 117-120 ◽  
Author(s):  
C. Sugiyama ◽  
Y. Miyamae ◽  
H. Kobayashi ◽  
Y. Fujino ◽  
M. Mori ◽  
...  
Keyword(s):  
Acridine Orange ◽  
Peripheral Blood ◽  
Micronucleus Test ◽  
Methyl Methanesulfonate
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